Multimodal treatment of patients with minor salivary gland cancer in the case of recurrent disease

Erovic, Boban M.; Schopper, Christian; Pammer, Johannes; Vormittag, Laurenz; Maleki, Amir Hossein; Brunner, Markus; Heiduschka, Gregor; Grasl, Matthäus Ch.; Thurnher, Dietmar

doi:10.1002/hed.21312

Cited by 15 publications

(18 citation statements)

References 21 publications

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“…Recently, Erovic et al . found that the T stage at presentation was a predictor of patients' disease‐free survival, but N stage was not 46 . Further, we suggest that prognostic factors related to NAC should be analyzed.…”

Section: Staging Systemmentioning

confidence: 69%

“…In a study at SYSUCC by Guo et al ., 17 the local control rate and the 5‐year disease‐free survival rate were 79 and 75% ( P = 0.724) in the radiotherapy‐treated group ( n = 32), and 90 and 89% ( P = 0.724) in the surgery plus radiotherapy ( n = 10) group, respectively. Early‐stage disease (T1 or T2) has been shown to be equally well controlled with either radiotherapy or surgery alone, but for advanced‐stage (T3 or T4) disease, combination radiotherapy following by surgery may significantly improve locoregional control rates 46,48–50 . ACC has a higher locoregional control rate (LRCR) than other histological types.…”

Section: Treatment and Prognosismentioning

confidence: 99%

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Primary nasopharyngeal adenocarcinoma: A review

Li²,

et al. 2012

Asia-Pac J Clncl Oncology

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Primary nasopharyngeal adenocarcinoma (NAC) accounts for approximately 0.5% of all nasopharyngeal cancer. The diagnosis, staging and treatment of NAC has not been well described. This article presents a literature review on NAC and identifies its characteristics and management. The NAC group of diseases contains various pathological types and has a series of specific clinical characteristics, including slow progression, a low incidence of neck masses and frequent cranial neuropathy. The Epstein-Barr virus may not play an important role in NAC carcinogenesis. The rarity of the disease makes the staging classification and treatment strategies of NAC parallel to those recommended for nasopharyngeal squamous carcinoma. Some patients might benefit from surgery, and radiotherapy using precise techniques might achieve good control for treating NAC, but the roles of chemotherapy and target therapy are not clear. The proper staging system and optimal treatment strategies need to be established in NAC.

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Section: Staging Systemmentioning

confidence: 69%

Section: Treatment and Prognosismentioning

confidence: 99%

Primary nasopharyngeal adenocarcinoma: A review

Li²,

et al. 2012

Asia-Pac J Clncl Oncology

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“…There are only a few reports of EGFR blockade to treat patients with recurrent MEC [6]. However, response was not observed for cetuximab monotherapy [16].…”

Section: Schlüsselwörtermentioning

confidence: 99%

Relapsing high grade mucoepidermoid carcinoma

et al. 2012

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“…The endoscopic endonasal technique permits a safe and feasible removal in selected cases, with promising oncologic outcomes and lower morbidity than with the external approaches . Moreover, adjuvant treatments can be associated to improve survival and reduce the risk of recurrences …”

Section: Introductionmentioning

confidence: 99%

“…9 Moreover, adjuvant treatments can be associated to improve survival and reduce the risk of recurrences. 10 The aim of this study was to analyze the clinical features, surgical treatment, and the survival outcomes in patients affected by ACC and treated endoscopically.…”

Section: Introductionmentioning

confidence: 99%

Endoscopic endonasal resection of adenoid cystic carcinoma of the sinonasal tract and skull base

et al. 2018

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Objectives Adenoid cystic carcinoma (ACC) is a locally aggressive salivary gland malignancy prone to perineural invasion and local recurrences. In the literature, few data exist to guide treatment when this tumor involves the paranasal sinuses and skull base. We report our experience in the management of sinonasal adenoid cystic carcinoma through an endoscopic endonasal approach. Methods Retrospective analysis of patients affected by sinonasal ACC treated through an endoscopic endonasal approach from 1997 to 2015, managed at the Universities of Varese and Brescia, Italy. Results Thirty‐four patients were included in the analysis. The ethmoid sinus (55.9%), nasal septum (17.7%), maxillary sinus (11.7%), and sphenoid sinus (5.9%) were the primary tumor sites encountered. Twenty patients (58.8%) presented with T3 or T4, without any systemic spreading. Twenty‐nine patients underwent endoscopic transnasal resection, whereas the involvement of the anterior skull base in five cases required a transnasal endoscopic craniectomy. Overall, 20 of 34 (58.8%) patients received some form of adjuvant radiotherapy. The follow‐up ranged from 12 to 202 months (mean of 73.2 months). The 5‐year overall, disease‐specific, and recurrence‐free survival rates were 86.5% ± 7.39%, 86.5% ± 7.39%, and 71.8% ± 8.67%, respectively. Conclusions The endoscopic approach is safe and effective for selected sinonasal ACC, reducing the comorbidities of the external approaches while producing similar oncological results. High T‐stage, grade III histology, positive surgical margins, and perineural infiltration all have an important negative prognostic value. Level of Evidence 4 Laryngoscope, 129:1071–1077, 2019

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Multimodal treatment of patients with minor salivary gland cancer in the case of recurrent disease

Abstract: The initial tumor classification is a clinical predictor for patients' overall and disease-free survival and overall survival after recurrence. Multimodal treatment significantly improves patients' overall survival.

Cited by 15 publications

References 21 publications

Primary nasopharyngeal adenocarcinoma: A review

Primary nasopharyngeal adenocarcinoma: A review

Relapsing high grade mucoepidermoid carcinoma

Endoscopic endonasal resection of adenoid cystic carcinoma of the sinonasal tract and skull base

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