2017
DOI: 10.1002/ehf2.12196
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Multimodality assessment of left ventricular dysfunction in Takayasu arteritis and familial hypercholesterolaemia

Abstract: Although left ventricular (LV) systolic dysfunction in patients suffering from Takayasu arteritis (TA) has been reported, little is known regarding the development of heart failure in these patients. We report a novel finding of active TA and familial hypercholesterolaemia presenting with severe LV dysfunction through multimodality assessments of LV systolic dysfunction.

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Cited by 2 publications
(5 citation statements)
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“…Both Takayasu arteritis and familial hypercholesterolemia provoke arterial stenosis as a result of inflammatory disorder of the arterial wall; however, the correlation of these diseases is unclear [13,14]. The pathologic backgrounds of these two diseases are different; lipid accumulation in vessel wall activates macrophages and yields the formation of the necrotic core in the state of hypercholesterolemia [15], whereas granulomatous inflammation of the media and adventitia with giant cells induces fibrotic thickening of the vessel wall in Takayasu arteritis.…”
Section: Discussionmentioning
confidence: 99%
“…Both Takayasu arteritis and familial hypercholesterolemia provoke arterial stenosis as a result of inflammatory disorder of the arterial wall; however, the correlation of these diseases is unclear [13,14]. The pathologic backgrounds of these two diseases are different; lipid accumulation in vessel wall activates macrophages and yields the formation of the necrotic core in the state of hypercholesterolemia [15], whereas granulomatous inflammation of the media and adventitia with giant cells induces fibrotic thickening of the vessel wall in Takayasu arteritis.…”
Section: Discussionmentioning
confidence: 99%
“…These cytotoxic mechanisms, similar to those believed to occur in the vasa vasorum, may cause left ventricular dysfunction 5 . A further possibility for systolic dysfunction is the increased afterload due to the affection of the aorta and peripheral vessels 1 . It remains uncertain if myositis ossificans, diagnosed 8 months before onset of heart failure, was also due to autoimmune mechanisms.…”
mentioning
confidence: 99%
“…Left ventricular systolic dysfunction and heart failure occur in up to 44% of patients with Takayasu arteritis. 1,2 Cardiac symptoms may develop before or after the vascular symptoms. Heart failure is attributed to uncontrolled arterial hypertension, myocardial ischemia due to coronary arteritis, premature atherosclerosis, aortic valve regurgitation, pulmonary hypertension, or myocarditis.…”
mentioning
confidence: 99%
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