Multimodality-imaging manifestations of primary renal-allograft synovial sarcoma: First case report and literature review

Xu, Ruifang; He, Enhui; Yi, Zhan-Xiong; Lin, Jun; Zhang, Yanning; Qian, Linxue

doi:10.12998/wjcc.v7.i13.1677

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…Immunohistochemical analyses constitute the most valid aid in orienting towards a diagnosis of SS [1,14,15]. Immunopositivity for vimentin, CD99, and BCL2 of the spindle cells and that of cyst epithelium for cytokeratins could be very useful [28,29] although biphasic variant is often negative to cytokeratins [1]. Moreover cytogenetics and molecular studies (FISH or RT-PCR) can reveal the translocation of t(X;18)(p11.2;q11.2) that is the fusion of SYT genechromosome 18-with SSX genes (1, 2 or 4)-chromosome X (SYT-SSX gene fusion protein, SS18-SSX2 is the most frequent), that are found in 90% of SS cases [1,20,[29][30][31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Primary renal synovial sarcoma with negative immunohistochemistry: a case report and literature review

Della Giustina,

Sartori,

Laurino

2024

J Med Imaging Intervent Radiol

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Just less than 200 cases of primary renal synovial sarcoma (PRSS) are known, a very rare neoplasm of the kidney. The diagnosis can be very challenging because of its similarity with other neoplasms, and is based on anatomopathological analyses, especially immunohistochemistry and cytogenetics. Due to the rarity, there are no standard protocols for treatment, although radical nephrectomy is considered the primary treatment and can be associated or not with chemotherapy. We present a case of PRSS with negative immunohistochemistry: the importance of both methods for a correct diagnosis is underlined, and a literature review of this rare entity is presented.

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Section: Discussionmentioning

confidence: 99%

Primary renal synovial sarcoma with negative immunohistochemistry: a case report and literature review

Della Giustina,

Sartori,

Laurino

2024

J Med Imaging Intervent Radiol

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Primary renal synovial sarcoma

Zhang

Tian

et al. 2020

Medicine

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Rationale: Synovial sarcoma (SS) is a malignant neoplasm that arises from soft tissues proximal to the joints. It occurs primarily at the major joints of the extremities, but may also occur in the deep soft tissues around the joints. While primary renal synovial sarcoma (PRSS) is extremely rare, it is important to have a better understanding of their imaging and clinical features to establish an effective treatment plan. Correct identification of PRSS is also useful for treating renal neoplasms. Patient's concerns: A 56-year-old Chinese man was admitted to our hospital due to moderate, paroxysmal left-sided loin pain. Diagnosis: Renal enhanced computed tomography (CT) scanning showed a relatively hypovascular lesion with calcification in the left kidney. A radical nephrectomy was performed in the left kidney. Postoperative pathology indicated SS with necrosis. The immunohistochemical findings were as follows: 34βE12 (Epithelium+), Bcl-2(+), CD99(+), CK-pan((Epithelium+), EMA(Epithelium+), Ki-67(+60%), and Vimentin(+), CD34(−). Interventions: The patient underwent radical left nephrectomy with no complications. Outcomes: After discharge, a close review for 3 months showed no evidence of recurrence. Lessons: PRSS should be considered for the differential diagnosis of renal hypovascular tumors. When problems arise in distinguishing renal hypovascular tumors, surgical pathology is helpful in the final diagnosis and further treatment of the disease.

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Synovial Sarcoma of the Kidney: Diagnostic Pitfalls in a Case with Myxoid Monophasic Differentiation and No Epithelial Biomarkers Expression

Pagliuca,

Carraturo,

De Chiara

et al. 2024

IJMS

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Synovial sarcomas are soft tissue tumours of uncertain origin, most commonly found in the upper or lower extremities. They are characterised by distinctive chromosomal rearrangements involving the gene SS18. Synovial sarcomas can occasionally arise also in visceral sites, but retroperitoneal SSs are very unusual. Among them, a few primary renal synovial sarcomas have been described in the scientific literature. Primary renal synovial sarcomas tend to be monophasic and often show cystic changes. Histologically, they can closely resemble other primary kidney tumours, mainly paediatric tumours such as nephroblastoma and clear cell sarcoma of the kidney. In the current work, a primary synovial sarcoma of the kidney with unusual morphological features (extensively myxoid stroma and immunohistochemical positivity for BCOR) is described. Molecular analysis, through targeted RNA sequencing, was of invaluable help in reaching the correct diagnosis. Despite locally advanced disease at presentation, the patient showed an unexpectedly brilliant response to chemotherapy.

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Multimodality-imaging manifestations of primary renal-allograft synovial sarcoma: First case report and literature review

Cited by 4 publications

References 15 publications

Primary renal synovial sarcoma with negative immunohistochemistry: a case report and literature review

Primary renal synovial sarcoma with negative immunohistochemistry: a case report and literature review

Primary renal synovial sarcoma

Synovial Sarcoma of the Kidney: Diagnostic Pitfalls in a Case with Myxoid Monophasic Differentiation and No Epithelial Biomarkers Expression

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