Multimodality imaging of breast hematomas and their mimickers

Abstract

While breast hematomas are common, their imaging features are often underrecognized or mistaken for other conditions. Diagnosis of acute hematomas is generally easy when associated with a recent history of breast trauma, surgery, or percutaneous biopsy. However, minor trauma might not always be remembered, and breast hematoma might have long lasting imaging manifestations when associated with fat necrosis. Also, because of the increasing use of breast MRI and FDG-PET/CT, breast hematomas are increasingly detected as incidentalomas, and may mimic malignancies. Conversely, breast hematomas may also be associated with authentic malignant processes. In this pictorial review, we present the natural history of breast hematomas, their various imaging features, as well as their differential diagnoses, highlighting the situations requiring histopathological correlation.

DNA-Mediated Magnetic-Dimer Assembly for Fault-Free Ultra-High-Field Magnetic Resonance Imaging of Tumors

“…To investigate the cellular internalization capacity of DMA, after labeled with Cy5, DMA was confirmed by confocal laser scanning microscope (CLSM) to be efficiently uptake after 2 h of coincubation with 4T1 cells (Figure S14). Due to the poor imaging sensitivity of clinical low-field MRI systems (≤3 T) and severe signal interference from complex artifacts, the challenge of accurately differentiating breast cancer from false positives, such as hematomas, is exacerbated. ,, To overcome these challenges, we harnessed the strength of a 9 T magnetic field and employed DMA-enhanced T1-T2 dual-mode MRI in conjunction with the DIF process to achieve precise identification of tumors amidst hematoma (Figure a). To simulate the different developmental stages of hematomas, we established the acute and subacute hematoma models on the flanks of in situ breast tumors in mice, separately.…”