Multimodality Imaging of Right Heart Function

Hahn, Rebecca T.; Delgado, Victoria; Addetia, Karima; Burkhoff, Daniel; Muraru, Denisa; Pinney, Sean; Friedberg, Mark K.

doi:10.1016/j.jacc.2023.03.392

Cited by 31 publications

(11 citation statements)

References 150 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A detailed description of the assessment of RV and right atrial function and TR by imaging is given in other reviews and position statements and goes beyond the aims of the present document. 1,6,33,[47][48][49][50][51] We only provide in the following paragraph a brief overview of the main imaging tools that can be adopted for the assessment of right heart chambers and TV in patients with HF.…”

Section: Imagingmentioning

confidence: 99%

“…The advent of myocardial deformation imaging and three-dimensional echocardiography has improved the accuracy of echocardiography to assess RV geometry and function, and prognostic stratification of patients. 1,50,[52][53][54][55][56] Echocardiographic cut-offs for the definition of RVD are highly debated, especially in presence of TR. A comprehensive classification have been recently proposed (online supplementary Table S2).…”

Section: Right Heart Chambersmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology, pathophysiology, diagnosis and management of chronic right‐sided heart failure and tricuspid regurgitation. A clinical consensus statement of the Heart Failure Association (HFA) and the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC

Adamo,

Chioncel,

Pagnesi

et al. 2024

European J of Heart Fail

Self Cite

View full text Add to dashboard Cite

Right‐sided heart failure and tricuspid regurgitation are common and strongly associated with poor quality of life and an increased risk of heart failure hospitalizations and death. While medical therapy for right‐sided heart failure is limited, treatment options for tricuspid regurgitation include surgery and, based on recent developments, several transcatheter interventions. However, the patients who might benefit from tricuspid valve interventions are yet unknown, as is the ideal time for these treatments given the paucity of clinical evidence. In this context, it is crucial to elucidate etiology and pathophysiological mechanisms leading to right‐sided heart failure and tricuspid regurgitation in order to recognize when tricuspid regurgitation is a mere bystander and when it can cause or contribute to heart failure progression. Notably, early identification of right heart failure and tricuspid regurgitation may be crucial and optimal management requires knowledge about the different mechanisms and causes, clinical course and presentation, as well as possible treatment options.The aim of this clinical consensus statement is to summarize current knowledge about epidemiology, pathophysiology and treatment of tricuspid regurgitation in right‐sided heart failure providing practical suggestions for patient identification and management.This article is protected by copyright. All rights reserved.

show abstract

Section: Imagingmentioning

confidence: 99%

Section: Right Heart Chambersmentioning

confidence: 99%

Epidemiology, pathophysiology, diagnosis and management of chronic right‐sided heart failure and tricuspid regurgitation. A clinical consensus statement of the Heart Failure Association (HFA) and the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC

Adamo,

Chioncel,

Pagnesi

et al. 2024

European J of Heart Fail

Self Cite

View full text Add to dashboard Cite

show abstract

“…Computed tomography (CT) scanning is a key investigation and can provide a comprehensive cardiopulmonary assessment. Although ECG-gated multidetector CT may provide additional information and cardiac magnetic resonance imaging is the gold-standard tool for assessment of RV function, this review will focus on CT pulmonary angiography (CTPA) in view of its wide clinical use [ 28 ]. A routine systematic approach to interpreting standard CTPA axial images is suggested to ensure that maximal information is gained ( figure 1 ).…”

Section: Systematic Radiological Assessmentmentioning

confidence: 99%

Clinical–radiological–pathological correlation in pulmonary arterial hypertension

Condliffe,

Durrington,

Hameed

et al. 2023

Eur Respir Rev

View full text Add to dashboard Cite

Pulmonary hypertension (PH) is defined by the presence of a mean pulmonary arterial pressure >20 mmHg. Current guidelines describe five groups of PH with shared pathophysiological and clinical features. In this paper, the first of a series covering all five PH classification groups, the clinical, radiological and pathological features of pulmonary arterial hypertension (PAH) will be reviewed. PAH may develop in the presence of associated medical conditions or a family history, following exposure to certain medications or drugs, or may be idiopathic in nature. Although all forms of PAH share common histopathological features, the presence of certain pulmonary arterial abnormalities, such as plexiform lesions, and extent of co-existing pulmonary venous involvement differs between the different subgroups. Radiological investigations are key to diagnosing the correct form of PH and a systematic approach to interpretation, especially of computed tomography, is essential.

show abstract

“…2 CMR is considered the gold standard for the assessment of right ventricular (RV) function and structure. 5 The prognostic role of RV dysfunction has been described in many forms of heart disease, including cardiomyopathies, pulmonary hypertension, and congenital heart conditions. 5 RV failure is one of the most important causes of death in the early phase after cardiac transplantation, along with acute graft rejection.…”

mentioning

confidence: 99%

“…5 The prognostic role of RV dysfunction has been described in many forms of heart disease, including cardiomyopathies, pulmonary hypertension, and congenital heart conditions. 5 RV failure is one of the most important causes of death in the early phase after cardiac transplantation, along with acute graft rejection. 6 Whether RV dysfunction in the stable phase after heart transplantation is associated with long-term adverse outcomes is unknown.…”

mentioning

confidence: 99%

Right Ventricular Function on Cardiovascular Magnetic Resonance Imaging and Long-Term Outcomes in Stable Heart Transplant Recipients

Barrett,

Bawaskar,

Hughes

et al. 2024

Circ: Cardiovascular Imaging

View full text Add to dashboard Cite

BACKGROUND: In heart transplant recipients, right ventricular (RV) dysfunction may occur for a variety of reasons. Whether RV dysfunction in the stable phase after heart transplantation is associated with long-term adverse outcomes is unknown. We aimed to determine the long-term prognostic significance of RV dysfunction identified on cardiovascular magnetic resonance imaging (CMR) at least 1 year after heart transplantation. METHODS: In consecutive heart transplant recipients who underwent CMR for surveillance, we assessed 2 CMR measures of RV function: RV ejection fraction and RV global longitudinal strain (RVGLS). We investigated associations between RV dysfunction and a composite end point of death or major adverse cardiac events, including retransplantation, nonfatal myocardial infarction, coronary revascularization, and heart failure hospitalization. RESULTS: A total of 257 heart transplant recipients (median age, 59 years; 75% men) who had CMR at a median of 4.3 years after heart transplantation were included. Over a median follow-up of 4.4 years after the CMR, 108 recipients experienced death or major adverse cardiac events. In a multivariable Cox regression analysis adjusted for age, time since transplantation, indication for transplantation, cardiac allograft vasculopathy, history of rejection, and CMR covariates, RV ejection fraction was not associated with the composite end point, but RVGLS was independently associated with the composite end point with a hazard ratio of 1.08 per 1% worsening in RVGLS ([95% CI, 1.00–1.17]; P =0.046). RVGLS provided incremental prognostic value over other variables in multivariable analyses. The association was replicated in subgroups of recipients with normal RV ejection fraction and recipients with late gadolinium enhancement imaging. A similar association was seen with a composite end point of cardiovascular death or major adverse cardiac events. CONCLUSIONS: CMR feature tracking–derived RVGLS assessed at least 1 year after heart transplantation was independently associated with the long-term risk of death or major adverse cardiac events. Future studies should investigate its role in guiding clinical decision-making in heart transplant recipients.

show abstract

Multimodality Imaging of Right Heart Function

Cited by 31 publications

References 150 publications

Epidemiology, pathophysiology, diagnosis and management of chronic right‐sided heart failure and tricuspid regurgitation. A clinical consensus statement of the Heart Failure Association (HFA) and the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC

Epidemiology, pathophysiology, diagnosis and management of chronic right‐sided heart failure and tricuspid regurgitation. A clinical consensus statement of the Heart Failure Association (HFA) and the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC

Clinical–radiological–pathological correlation in pulmonary arterial hypertension

Right Ventricular Function on Cardiovascular Magnetic Resonance Imaging and Long-Term Outcomes in Stable Heart Transplant Recipients

Contact Info

Product

Resources

About