Multimodality Therapy of Localized Gastric Adenocarcinoma

Badgwell, Brian D.

doi:10.6004/jnccn.2016.0139

Cited by 33 publications

(24 citation statements)

References 31 publications

(39 reference statements)

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“…Further, because clinical stage information in the NCDB is inadequate, the cStage was created by using data for 4091 gastric cancer patients from Shizuoka Cancer Center in Japan. The use of this population may be problematic because the tumor biology of gastric cancer and clinical staging accuracy are likely different between Japan and the United States [5]. Moreover, use of preoperative therapy has been increasing in the United States, and it is not known whether survival predictions based on clinical stage are valid in patients who undergo preoperative therapy.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the American Joint Committee on Cancer 8th edition staging system for gastric cancer patients after preoperative therapy

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Evaluation of the American Joint Committee on Cancer 8th edition staging system for gastric cancer patients after preoperative therapy

et al. 2017

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“…Electronic endoscopy, endoscopic ultrasonography, cranial, chest and abdominal CT scan, abdominal ultrasonography and other tests were performed prior to the surgery to determine the clinical stage and rule out metastasis 6 . PET-CT and bone scans were performed when necessary.…”

Section: Methodsmentioning

confidence: 99%

Outcomes of Laparoscopic Total Gastrectomy for Elderly Gastric Cancer Patients

2018

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Purpose: The purpose of this study was to compare the short- and long-term outcomes after laparoscopic total gastrectomy (LTG) between elderly and non-elderly patients with gastric cancer.Methods: A retrospective analysis was performed using clinical and follow-up data from 168 patients treated with LTG for gastric cancer at our institution from January 2010 to December 2017. For this study, the short- and long-term outcomes (including tumor recurrence rate, disease-free survival rate, and overall survival rate) were compared between the elderly group (≥70 years) and non-elderly group (<70 years).Results: The preoperative American Society of Anesthesiologists score and Charlson Comorbidity Index were higher in the elderly group than in the non-elderly group, while there was no significant difference between the two groups in terms of operation duration, intraoperative blood loss, and rate of conversion to laparotomy. The incidence of postoperative 30-day complications in the elderly group was higher than that in the non-elderly group due to a higher incidence of pulmonary infection, while the incidence of major complications was similar in both groups. The tumor recurrence rate was also similar in both groups. There was no statistically significant difference between the two groups in terms of 5-year disease-free survival and 5-year overall survival rate.Conclusions: LTG is safe and feasible for elderly patients with gastric cancer and is associated with relatively good long-term outcomes.

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“…Nevertheless, the identification of one or several genes as biomarkers for application in the non-invasive tumor molecular diagnosis of GC, and the better understanding of GC pathogenesis is essential for the establishment of diagnostic markers, as well as novel therapeutic methods. In the treatment of GC, surgery alone is often not very effective (6), even in patients with relatively early stages of the disease. In an attempt to reduce systemic recurrence following surgery alone, adjuvant chemotherapy has been used in trials (7); however, the effects are still limited (8).…”

Section: Introductionmentioning

confidence: 99%

Identification of significant biomarkers and pathways associated with gastric carcinogenesis by whole genome-wide expression profiling analysis

et al. 2018

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The incidence of gastric cancer (GC) is extremely high in East Asia. GC is also one of the most common and lethal forms of cancer from a global perspective. However, to date, we have not been able to determine one or several genes as biomarkers in the diagnosis of GC and have also been unable to identify the genes which are important in the therapy of GC. In this study, we analyzed all genome-wide expression profiling arrays uploaded onto the Gene Expression Omnibus (GEO) database to filtrate the differentially expressed genes (DEGs) between normal stomach tissues and GC tissues. GSE13911, GSE19826 and GSE79973 were based on the GPL570 platform, and GSE29272 was based on the GPL96 platform. We screened out the DEGs from the two platforms and by selecting the intersection of these two platforms, we identified the common DEGs in the sequencing data from different laboratories. Finally, we obtained 3 upregulated and 34 downregulated DEGs in GC from 384 samples. As the number of downregulated DEGs was greater than that of the upregulated DEGs, functional analysis and pathway enrichment analysis were performed on the downregulated DEGs. Through our analysis, we identified the most significant genes associated with GC, such as secreted phosphoprotein 1 (SPP1), sulfatase 1 (SULF1), thrombospondin 2 (THBS2), ATPase H+/K+ transporting beta subunit (ATP4B), gastric intrinsic factor (GIF) and gastrokine 1 (GKN1). The prognostic power of these genes was corroborated in the Oncomine database and by Kaplan-Meier plotter (KM-plotter) analysis. Moreover, gastric acid secretion, collecting duct acid secretion, nitrogen metabolism and drug metabolism were significantly related to GC. Thus, these genes and pathways may be potential targets for improving the diagnosis and clinical effects in patients with GC.

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Multimodality Therapy of Localized Gastric Adenocarcinoma

Cited by 33 publications

References 31 publications

Evaluation of the American Joint Committee on Cancer 8th edition staging system for gastric cancer patients after preoperative therapy

Evaluation of the American Joint Committee on Cancer 8th edition staging system for gastric cancer patients after preoperative therapy

Outcomes of Laparoscopic Total Gastrectomy for Elderly Gastric Cancer Patients

Identification of significant biomarkers and pathways associated with gastric carcinogenesis by whole genome-wide expression profiling analysis

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