Multimodality treatment in recurrent/metastatic squamous cell carcinoma of head and neck: current therapy, challenges, and future perspectives

Pannunzio, Sergio; Di Bello, Armando; Occhipinti, Denis; Scala, Alessandro; Messina, Gloria; Valente, Giustina; Quirino, Michela; Di Salvatore, Mariantonietta; Tortora, Giampaolo; Cassano, Alessandra

doi:10.3389/fonc.2023.1288695

Cited by 2 publications

(1 citation statement)

References 136 publications

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“…Each team could use, on the basis of its own expertise, a different test to assess the urgency and the modality to support the patients ( 20 ).…”

Section: Resultsmentioning

confidence: 99%

Nutrition in HNSCC: is it a matter for oncologists? The role of multidisciplinary team—a narrative literature review

Denaro,

Bareggi,

Galassi

et al. 2024

Front. Oncol.

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BackgroundMalnutrition, defined as weight loss and unsatisfactory nutrient intake, is very common in patients with head and neck squamous cell carcinoma (HNSCC) in either the early or palliative setting. Despite increased awareness, nutritional programs are not yet adequately implemented in these patients. There are several reasons for this delay: differences in composition, the expertise of the multidisciplinary teams involved in HNSCC patients’ treatment, and economic and network resources conditioning faster or slower nutritional supply delivery. This situation affects the outcomes and the quality of life of HNSCC patients.Materials and methodsWe investigated available literature about nutritional support in HNSCC patients and its impact on outcomes, prognosis, and quality of life, and we focused on the role of the multidisciplinary team. We considered 8,491 articles, and after excluding duplicates and manuscripts not written in English, 1,055 were analyzed and 73 were deemed eligible for the present work.ResultsAfter the literature review, we can state that malnutrition, sarcopenia, and cachexia are associated with systemic inflammation and closely correlated with poor outcomes. An evaluation of the nutritional status of the multidisciplinary team before, during, and after therapy could improve patient outcomes, as the goal of the therapeutic approach is widely designed.ConclusionsWe suggest that the treatment workflow definition is fundamental and propose a tailored nutritional approach that could benefit HNSCC patients’ outcomes and quality of life. These results could be achieved by a multidisciplinary team.

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“…Each team could use, on the basis of its own expertise, a different test to assess the urgency and the modality to support the patients ( 20 ).…”

Section: Resultsmentioning

confidence: 99%

Nutrition in HNSCC: is it a matter for oncologists? The role of multidisciplinary team—a narrative literature review

Denaro,

Bareggi,

Galassi

et al. 2024

Front. Oncol.

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Investigating the Anticancer Potential of Biochanin A in KB Oral Cancer Cells Through the NFκB Pathway

Nivedha,

Vennila,

Sindhu

et al. 2024

Cell Biochemistry & Function

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Squamous cell carcinoma (SCC) is a malignancy primarily affecting squamous cells. Its development is linked to multiple risk factors, such as alcohol and tobacco consumption, human papillomavirus (HPV) infection, and Epstein‐Barr Virus (EBV) infection. Biochanin A (BCA), a phytoestrogen extracted from red clover, has been extensively researched for its therapeutic properties. It spans antioxidant activity, anti‐inflammatory effects, neuroprotection, cardioprotection, and anticancer potential in different bodily systems. However, its impact on oral cancer remains unexplored. Therefore, this investigation aims to assess the potential anticancer effects of BCA, specifically on KB oral cancer cells. This study utilized KB cells to evaluate the impact of BCA on various cellular parameters, including cell viability, apoptosis, intracellular ROS production, mitochondrial membrane potential, and cell migration. BCA treatment induced several notable effects on KB cells, including reduced cell viability, altered morphology suggestive of apoptosis, heightened oxidative stress, and alterations in mitochondrial membrane potential. Moreover, BCA treatment demonstrated an inhibitory effect on cell migration. The study further investigated the impact of BCA on antioxidant enzyme activities and lipid peroxidation, revealing decreased antioxidant enzyme activities and increased lipid peroxidation across different BCA concentrations (IC50 and IC90). Immunocytochemistry and qRT‐PCR analyses unveiled that BCA treatment at varying doses (IC50 and IC90) downregulated the expression of nuclear factor‐κB (NF‐κB) subunits p50 and p65, pivotal players in cancer progression. In summary, this study sheds light on the promising potential of BCA as an anticancer therapeutic agent for treating oral cancer. Its demonstrated ability to induce apoptosis, perturb cellular functions, and modulate gene expression within cancer cells underscores its significance. Nonetheless, further research, particularly following animal studies, is imperative to comprehensively grasp the breadth of BCA's effects and its viability for clinical applications.

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Multimodality treatment in recurrent/metastatic squamous cell carcinoma of head and neck: current therapy, challenges, and future perspectives

Cited by 2 publications

References 136 publications

Nutrition in HNSCC: is it a matter for oncologists? The role of multidisciplinary team—a narrative literature review

Nutrition in HNSCC: is it a matter for oncologists? The role of multidisciplinary team—a narrative literature review

Investigating the Anticancer Potential of Biochanin A in KB Oral Cancer Cells Through the NFκB Pathway

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