Multimodel Approach for Modelling of Biotechnological Processes

Pencheva, Tania; Vassileva, Svetla; Ilkova, Tatiana; Georgieva, Y.; Hitzmann, Bernd; Tzonkov, Stoyan

doi:10.1080/13102818.2004.10817112

Cited by 1 publication

(2 citation statements)

References 26 publications

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“…Thus, based on relatively simpler models more accurate description of the process dynamics is achieved. [ 4 ] This methodology allows for partial transparency of process knowledge to the modelling procedure.…”

Section: Functional State Modelling Approachmentioning

confidence: 99%

“…The FSM approach was originally developed by Zhang et al [ 2,3 ] for aerobic yeast growth processes and several works have already shown its benefits. [ 4,5 ] Its applicability to the mathematical modelling of Saccharomyces cerevisiae CEN.PK haploid batch and S. cerevisiae DY 7221 fed-batch cultivations has been shown. [ 6,7 ] This approach can be used not only for process predictions, but also for early stabilization of process,[ 7 ] robust control,[ 8 ] model-based control [ 9 ] and design of multiple-model non-linear adaptive control algorithms.…”

Section: Introductionmentioning

confidence: 99%

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Functional state modelling approach validation for yeast and bacteria cultivations

Roeva

Pencheva

2014

Biotechnology & Biotechnological Equipment

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In this paper, the functional state modelling approach is validated for modelling of the cultivation of two different microorganisms: yeast (Saccharomyces cerevisiae) and bacteria (Escherichia coli). Based on the available experimental data for these fed-batch cultivation processes, three different functional states are distinguished, namely primary product synthesis state, mixed oxidative state and secondary product synthesis state. Parameter identification procedures for different local models are performed using genetic algorithms. The simulation results show high degree of adequacy of the models describing these functional states for both S. cerevisiae and E. coli cultivations. Thus, the local models are validated for the cultivation of both microorganisms. This fact is a strong structure model verification of the functional state modelling theory not only for a set of yeast cultivations, but also for bacteria cultivation. As such, the obtained results demonstrate the efficiency and efficacy of the functional state modelling approach.

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Section: Functional State Modelling Approachmentioning

confidence: 99%