Multimolecular Characteristics and Role of BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) in Human Tumors: A Pan-Cancer Analysis

Abstract

Background The aberrant expression of BRIP1 was associated with several cancers, the panoramic picture of BRIP1 in human tumors is unclear. The purpose of this study is to explore the panoramic picture of expression of BRIP1 which was associated with several cancers. Methods Based on the data from TCGA, we utilized online databases to systematically analyze the multimolecular characteristics of BRIP1 in 33 human tumors. Results We observed prognosis-related differential BRIP1 expression between various carcinomas and the corresponding normal tissues. “Basal transcription factors”, “Homologous recombination”, “Nucleotide excision repair”, and DNA metabolism pathways may play a role in the functional mechanisms of BRIP1. Patients with uterine corpus endometrial carcinoma presented with the highest alteration frequency of BRIP1 (near 10%). Single nucleotide and copy number variation of BRIP1 were noticed in multiple cancer, and the expression of BRIP1 is significantly regulated by copy number variation in breast invasive carcinoma and lung squamous cell carcinoma. BRIP1 expression was negatively correlated to the methylation level in many human tumors, and the expression was associated with the activation of apoptosis, cell cycle, and DNA damage response, and inhibition of hormone ER and RNS/MARK signaling pathways. Moreover, a positive correlation was observed between BRIP1 expression and the immune infiltration level of cancer-associated fibroblasts and CD8 + T cells in lung adenocarcinoma. Conclusion Our pan-cancer analysis of BRIP1 provide valuable resource for understanding the characteristics of BRIP1 across human cancers.