Multimorbidity Burden and Incident Heart Failure Among People With and Without HIV: The HIV-HEART Study

Mefford, Matthew T.; Silverberg, Michael J.; Leong, Thomas K.; Hechter, Rulin C.; Towner, William; Go, Alan S.; Horberg, Michael A.; Harrison, Teresa N.; Sung, Sue Hee; Reynolds, Kristi

doi:10.1016/j.mayocpiqo.2022.03.004

Cited by 2 publications

(5 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, a study that examined the association of multimorbidity in people with HIV with incident heart failure selected conditions associated with increased risk for hospitalization among adults with heart failure. However, authors did not consider conditions associated with this outcome among people with HIV generally [ 25 ]. It is important that conditions are selected based on clinical significance, but authors should consider conditions that contribute to a broader physical and psychosocial burden (e.g.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies [24][25][26] selected their conditions based on guidelines from either the European AIDS Clinical Society (EACS) [27] or the US Department of Health and Human Services (DHHS) [28]. Selection of conditions based on the EACS guidelines suggests that authors have considered relevant conditions for people with HIV.…”

Section: Guidelines/recommendations From Health Organizationsmentioning

confidence: 99%

See 1 more Smart Citation

Defining multimorbidity in people with HIV – what matters most?

Sukumaran

Sabin

2023

Current Opinion in HIV and AIDS

View full text Add to dashboard Cite

Purpose of reviewAlthough multimorbidity (defined as the coexistence of multiple conditions) presents significant health challenges to people with HIV, there is currently no consensus on how it should be defined among this population. This review aimed to examine the definition of multimorbidity in existing studies among people with HIV (n = 22).Recent findingsVariation in the definition of multimorbidity (in terms of the number and nature of conditions included) across studies among people with HIV was observed, with less than half (45%) reporting a selection criteria for conditions. The number of conditions considered ranged from 4 to 65. Certain conditions (e.g. stroke, myocardial infarction and chronic kidney disease) and risk factors (e.g. hypertension) were more frequently included, while other symptoms (e.g. joint pain, peripheral neuropathy and sleeping problems) and mental health conditions (e.g. anxiety and panic attacks) were rarely included in the definition of multimorbidity.SummaryThe definition of multimorbidity among people with HIV is highly variable, with certain conditions overlooked. We propose recommendations that researchers should consider when defining multimorbidity among this population to not only enable comparisons between studies/settings but also to ensure studies consider a person-centred approach that can accurately capture multimorbidity among people with HIV.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Guidelines/recommendations From Health Organizationsmentioning

confidence: 99%

Defining multimorbidity in people with HIV – what matters most?

Sukumaran

Sabin

2023

Current Opinion in HIV and AIDS

View full text Add to dashboard Cite

show abstract

“…34,35 The prevalence of multimorbidity in PLHIV ranges from 16% to 75% depending on the definition employed. 6,10,23,[36][37][38] Other than being at a higher risk of coinfections and opportunistic infections, PLHIV also experience accelerated aging due to the complex interaction between the patient's lifestyle, ongoing inflammation despite good virological control, and toxicity from ART. However, the exact underlying mechanisms resulting in accelerated aging remain to be elucidated.…”

Section: Multimorbidity In Older People Living With Hivmentioning

confidence: 99%

“…1. 36,43,44 For example, neurocognitive impairment is common in older PLHIV, 15 which results in treatment non-adherence, leading to a vicious cycle of deterioration requiring additional therapies and further nonadherence. The cumulative burden of comorbidities and their therapies leads to frailty in PLHIV at a younger age.…”

Section: Adverse Outcomesmentioning

confidence: 99%

“…Multimorbidity is associated with many adverse outcomes in older PLHIV, including frailty, functional decline, disability, hospitalization and use of healthcare resources, reduced quality of life and higher mortality, as illustrated in Fig. 1 36,43,44 . For example, neurocognitive impairment is common in older PLHIV, 15 which results in treatment non‐adherence, leading to a vicious cycle of deterioration requiring additional therapies and further non‐adherence.…”

Section: Effects Of Multimorbiditymentioning

confidence: 99%

See 1 more Smart Citation

An overview of multimorbidity and polypharmacy in older people living with HIV

Yang,

Teh,

Chua

et al. 2023

Geriatrics Gerontology Int

View full text Add to dashboard Cite

The availability of effective antiretroviral therapy (ART) has revolutionized the care of people living with HIV (PLHIV). As a result, PLHIV now have a life expectancy comparable with that of the general population. PLHIV are increasingly confronted with age‐related comorbidities and geriatric syndromes, including frailty and polypharmacy, which occur at a higher prevalence and set in at an earlier age compared with their uninfected counterparts. The underlying pathophysiology for multimorbidity and polypharmacy are multifactorial, multidimensional and complex. Therefore, regular review and optimization of risk factors to maintain physical function, social and psychological health is of utmost importance. With an ever‐growing population of older PLHIV, there is a pressing need to provide holistic care to address these emerging issues. Accelerated aging observed in PLHIV suggests that early involvement of a multidisciplinary team, including geriatricians, and implementation of integrated models of care can potentially improve the care of older PLHIV, who are at increased risk of frailty and complex multimorbidity. This article reviews the current global situation, discusses the challenges involved and suggests approaches to deliver comprehensive care for older PLHIV. Geriatr Gerontol Int 2023; ••: ••–••.

show abstract

Multimorbidity Burden and Incident Heart Failure Among People With and Without HIV: The HIV-HEART Study

Cited by 2 publications

References 49 publications

Defining multimorbidity in people with HIV – what matters most?

Defining multimorbidity in people with HIV – what matters most?

An overview of multimorbidity and polypharmacy in older people living with HIV

Contact Info

Product

Resources

About