Multimorbidity in asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GA<sup>2</sup>LEN study

Blöndal, Viiu; Malinovschi, Andreï; Sundbom, Fredrik; James, Anna; Middelveld, Roelinde; Franklin, Karl A.; Lundbäck, Bo; Janson, Christer

doi:10.1111/cea.13759

Cited by 15 publications

(21 citation statements)

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“…19,25,26 Multimorbidity in asthma that is associated with other allergic diseases deserves special attention, as this is a burden for patients and may be associated with other health challenges, such as anxiety and depression. 27 This further reiterates the need for vigilance in diagnosing and treating asthma and allergic diseases.…”

Section: Discussionmentioning

confidence: 94%

Longitudinal asthma and allergy study showed that childhood symptoms frequently persisted into adulthood

et al. 2021

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Allergic diseases, eczema, asthma and allergic rhinitis are the most common chronic health disorders in children, 1,2 and several studies have described increasing prevalence rates over the last few decades. [3][4][5] Variations in prevalence, and changes over time, strongly indicate genetic predisposition and environmental influences. 6 While the prevalence is still increasing in lower income countries, 7,8 it seems to have plateaued in many western societies. 3,7 The incidence and prevalence of allergic diseases in Icelandic adults have been lower than in many other European countries. [9][10][11] Allergic diseases in children are more prevalent in Iceland than in neighbouring countries, despite lower concentrations of allergens in Iceland than in most European countries. 9,11 However, high, and sometimes increasing, incidences of allergic diseases have been described in the Nordic countries 12,13 and the need to diagnose asthma in adulthood has been reiterated. 14 Icelandic individuals born in 1987 have been followed by our research group for three decades 10,15-17 and repeatedly evaluated for allergic diseases, namely eczema, asthma and allergic rhinitis. Our previous studies gathered information on family histories of allergic diseases and environmental factors and carried out physical examinations and skin-prick tests and blood tests that included measuring immunoglobulin and identifying specific

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Section: Discussionmentioning

confidence: 94%

Longitudinal asthma and allergy study showed that childhood symptoms frequently persisted into adulthood

et al. 2021

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“…AS, rhinitis and eczema together are a higher risk for seasonal allergy than AS only. Further, food allergies were more common in those with all three allergic diseases compared with those with AS only 11 …”

Section: Introductionmentioning

confidence: 93%

Allergic multimorbidity is associated with self‐reported anaphylaxis in adults—A cross‐sectional questionnaire study

Thomander

Toppila‐Salmi

Salimäki³

et al. 2022

Clinical & Translational All

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Background Anaphylaxis has increased over the last two decades in Europe, reaching an estimated prevalence of 0.3% and an incidence of 1.5–7.9 per 100,000 person‐years. Allergic multimorbidity is associated with asthma severity, yet its role in anaphylaxis is not fully understood. Our aim was to study association between allergic multimorbidity and anaphylaxis in adults. Methods We used population‐based data from the Finnish Allergy Barometer Study (n = 2070, age range: 5–75). Food allergy (FA), atopic dermatitis (AD), allergic rhinitis (AR) and allergic conjunctivitis (AC), were defined from a self‐completed questionnaire. A logistic regression adjusted on potential confounders (sex, age, smoking status) was applied to estimate the anaphylaxis risk associated with allergic multimorbidity. Results 1319 adults with at least one allergic disease (FA, AD, AR, AC) with/without asthma (AS) were included. Of these, 164 had self‐reported anaphylaxis [mean (SD, min‐max) 54 (14, 22–75) years, 17% men]. AS, FA, AR, AC, or AD were reported by 86.0%, 62.2%, 82.3%, 43.3%, and 53.7% of subjects with anaphylaxis and respectively by 67.8%, 29.5%, 86.2%, 29.4%, and 34.4% of subjects without anaphylaxis. Compared with subjects exhibiting only one allergic disease, the risk of anaphylaxis increased with the number of allergic diseases; adjusted odds ratios (OR) [CI95%] for two, three, four and five coinciding allergic diseases were 1.80 [0.79–4.12], 3.35 [1.47–7.66], 7.50 [3.25–17.32], and 13.5 [5.12–33.09], respectively. The highest risk of anaphylaxis (6.47 [4.33–9.92]) was associated with FA + AS or their various variations with AR/AC/AD embodied, when compared with AR, AC, and AS separately or their combinations. Conclusions Anaphylaxis was positively associated with the number of allergic diseases a subject exhibited and with subgroups including FA and/or AS. The results can be applied when estimating the risk of anaphylaxis for individual patients.

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“…Climate change is dramatically changing our environment, and the effects are now noticeable for those with respiratory allergic diseases such as asthma. 1 The elevation in atmospheric carbon dioxide concentrations can impact plant and fungal biology, with potentially more potent pollen. 2 Climate change is likely to drive wet winters, warmer spring and hot summers in temperate regions.…”

Section: What Does Climate Change Mean For People With Pollen Allergy?mentioning

confidence: 99%

What does climate change mean for people with pollen allergy?

Shamji

Boyle

2021

Clin Experimental Allergy

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Multimorbidity in asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GA²LEN study

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 15 publications

References 51 publications

Longitudinal asthma and allergy study showed that childhood symptoms frequently persisted into adulthood

Longitudinal asthma and allergy study showed that childhood symptoms frequently persisted into adulthood

Allergic multimorbidity is associated with self‐reported anaphylaxis in adults—A cross‐sectional questionnaire study

What does climate change mean for people with pollen allergy?

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Multimorbidity in asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GA2LEN study

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 15 publications

References 51 publications

Longitudinal asthma and allergy study showed that childhood symptoms frequently persisted into adulthood

Longitudinal asthma and allergy study showed that childhood symptoms frequently persisted into adulthood

Allergic multimorbidity is associated with self‐reported anaphylaxis in adults—A cross‐sectional questionnaire study

What does climate change mean for people with pollen allergy?

Contact Info

Product

Resources

About

Multimorbidity in asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GA²LEN study