Multimorbidity of Upper Respiratory Tract Pathology in Children With Bronchial Asthma

Krasilnikova, S.V.; Eliseeva, T.I.; Popov, K; Tush, E.V.; Khaletskayav, O.V.; Ovsyannikov, D.Yu.; Балаболкин, И.И.; Шахов, А. В.; Prahov, A.V.

doi:10.24110/0031-403x-2018-97-2-19-26

Cited by 12 publications

(9 citation statements)

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“…In all patients, allergic rhinitis (AR) was verified, both persistent 72/82 (87.8%) and intermittent 10/82 (12.2%). This is consistent with both our before published data and data provided by Blaiss [ 18 , 19 , 27 ].…”

Section: Resultssupporting

confidence: 94%

“…Also, up to 80% of patients with BA of preschool age and up to 20% of children with BA of school age had hypertrophy of the pharyngeal tonsil. Some patients with asthma had a combination of anomalies of intranasal structures and hypertrophy of the pharyngeal tonsil [ 27 ]. In recent years, there have been studies that prove the negative effect of nasal obstructive disorders (NOD) on the course and the results of AR and ARS therapy [ 28 – 30 ].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Nasal Obstructive Disorders on Sinonasal Symptoms in Children with Different Levels of Bronchial Asthma Control

Eliseeva

Krasilnikova

Геппе

et al. 2018

Canadian Respiratory Journal

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Allergic rhinitis (AR) and allergic rhinosinusitis (ARS) are typical upper airway pathologies (UAP) in children with bronchial asthma (BA) frequently accompanied with nasal obstructive diseases (NOD). In order to establish the effect of NOD on correlations between nasal and synonasal symptoms with clinical assessments of asthma control, 82 children, 9.8 [8.9; 10.7] years old, with atopic BA were assessed using ACQ-5 for the BA control level, TNSS for nasal symptoms, and SNOT-20 for synonasal quality of life in combination with rhinovideoendoscopy for NOD. All patients had AR/ARS; in 76.3% (63/82) of children, UAP had a multimorbid character with the presence of NOD. Significant correlations were found between ACQ-5 and TNSS (R=0.40, p < 0.0001) and ACQ-5 and SNOT-20 (R=0.42, p < 0.0001). Correlations between TNSS/ACQ-5 and SNOT-20/ACQ-5 were higher in patients who do not have a combination of AR/ARS with NOD (R=0.67, p=0.0012; R=0.50, p=0.022, resp.) than in patients who have AR/ARS combined with NOD (R=0.30, p=0.015; R=0.26, p=0.04, resp.). Thus, the association of BA control level with the expression of nasal and synonasal symptoms is higher in children who do not have multimorbid UAP.

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Section: Resultssupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Effect of Nasal Obstructive Disorders on Sinonasal Symptoms in Children with Different Levels of Bronchial Asthma Control

Eliseeva

Krasilnikova

Геппе

et al. 2018

Canadian Respiratory Journal

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“…In all examined patients with asthma, AR was verified as persistent 86.4% (57/66) or intermittent 13.6% (9/66). This strong association of BA and AR is consistent with our previously published data, as well as with the data provided by Blaiss et al [ 2 , 39 ]. According to the severity of AR, the following distribution of patients was obtained: 12.1% (8/66) of children were diagnosed with AR of mild course, moderate AR was found in 81.8% (54/66), and severe AR was found in 6.1% (4/66) of the children.…”

Section: Resultssupporting

confidence: 94%

“…In particular, in the study of Chen et al [ 9 ], the AARM method was used to study nasal patency in children with asthma and nasal symptoms, but patients with anatomical deformations of upper airways were excluded from the study cohort. At the same time, according to our data, up to 50% of children with asthma and nasal symptoms have such deformations [ 2 , 7 ]. Motomura et al [ 19 ] demonstrated that, for patients with asthma, a decrease in nasal airflow is characteristic, but the effect of the comorbid UAP on the respiratory function of the nose was not considered.…”

Section: Introductionmentioning

confidence: 87%

“…They demonstrate the mutual influence of respiratory patency of the upper and lower airways [ 16 ]. Unfortunately, these studies do not take into account the possible impact on nasal respiratory patency of NOD, which, along with AR, occurs in a significant proportion of asthmatic children [ 2 , 17 ]. These diseases, including nasal septum deformity, can exacerbate nasal obstruction caused by allergic inflammation of the mucosa in AR and cause insufficient response to ongoing anti-inflammatory therapy [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Dependence of Anterior Active Rhinomanometry Indices on Nasal Obstructive Disorders in Children with Atopic Bronchial Asthma Complicated by Nasal Symptoms

Eliseeva

Krasilnikova

Babaev

et al. 2018

BioMed Research International

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Background Atopic bronchial asthma (BA) in children is associated with upper airways pathology (UAP). Among them, a combination of allergic rhinitis (AR) and nasal obstructive disorders (NOD), including hypertrophy of the pharyngeal tonsil (HPT) and anomalies of the intranasal structures (AINS), is abundant. In such patients, anterior active rhinomanometry (AARM) is an important method of examining nasal patency. However, NOD can influence the AARM parameters in children with BA and nasal symptoms, and this effect must be taken into account in clinical practice. Study goal was to elucidate the effect of NOD on rhinomanometric parameters in this group of patients. MethodsTotal of 66 children with BA and AR were examined with AARM, rhinovideoendoscopy, spirometry, and standard clinical tests allowing revealing the structure of comorbid pathologies. In order to avoid the influence of anthropometric parameters of children and their age on AARM parameters, a special index of reduced total nasal airflow was used. ResultsIt has been established that NOD, especially HPT, have a significant negative impact on the indices of anterior active rhinomanometry during the periods of both AR remission and AR exacerbation. The effect of AINS is much weaker and was remarkable only in combination with HPT.

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Functional prognosis of acute ischemic stroke patients from their neuropsychological features

Repina,

Romanova,

Poverennova

et al. 2021

Saratov Med J

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The objective was to evaluate the relationship between the patient neuropsychological condition and recovery of his/her motor activity disorder due to acute cerebrovascular accident. Materials and Methods. The study involved 103 patients with ischemic stroke in the pools of middle and anterior cerebral arteries. We carried out clinical and neurological assessments of the patient condition, and conducted neuropsychological testing via Beck Hopelessness Scale (BHS), Montreal Cognitive Assessment (MоCA), SF-36, and Visual Analog Scale (VAS). The examination was performed on three occasions: during the acute phase of cerebral circulatory disorders, after two weeks and within the range of 24-36 months. After the long-term follow-up, all patients were distributed among two groups: with a favorable outcome and with unfavorable outcome. We attempted to identify the most typical values of above-mentioned scales for each group. Results. The general physical health (GPhH) indicators based on the results of SF-36 (p=0.007), BHS (p=0.003 and 0.002), and VAS (p=0.025), collected after acute ischemic stroke, were prognostically significant. In both groups, the most important indicators for the stroke prognosis were MоCA (p=0.038), BHS (p=0.009) and SF-36 (GPH) (p=0.002), regardless of the stroke phase. Conclusion. The connection between the patient neuropsychological condition and restoring the motor functions after the stroke was revealed. The investigated questionnaires can be included in the multivariate forecast model of the stroke prognosis among other criteria for the outcome of this disease.

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Multimorbidity of Upper Respiratory Tract Pathology in Children With Bronchial Asthma

Cited by 12 publications

References 0 publications

Effect of Nasal Obstructive Disorders on Sinonasal Symptoms in Children with Different Levels of Bronchial Asthma Control

Effect of Nasal Obstructive Disorders on Sinonasal Symptoms in Children with Different Levels of Bronchial Asthma Control

Dependence of Anterior Active Rhinomanometry Indices on Nasal Obstructive Disorders in Children with Atopic Bronchial Asthma Complicated by Nasal Symptoms

Functional prognosis of acute ischemic stroke patients from their neuropsychological features

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