This paper constructs a composite indicator of well-being for 168 European regions with data from 10 well-being domains. Regions are then ranked according to their respective levels of well-being. The ranking reveals notable differences across European regions, which follow a marked spatial pattern. As a second contribution, the paper analyses the impact of the quality of government on well-being. Results show a positive association robust to several specifications and scenarios. Moreover, the effects of quality of government on individual well-being dimensions are identified, finding positive links with education, jobs, income, safety civic engagement, access to services, housing and community support. KEYWORDS composite well-being indicators, European regions, government quality JEL CLASSIFICATION C14; C61; I31; H41; R50