Multinodular goitre: a clinicopathological study from Kerala

Asokan, Meena; Cholakkal, Shanavas; Susheela, Bibilash Babu; Abdurahiman, Hima

doi:10.18203/2349-2902.isj20204132

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…22,23 A preoperative risk assessment that considers clinical, imaging, and cytological information is helpful in decisions about initial treatment. 24,25 There is now growing body of evidence that a substantial proportion of patients with multinodular goiter have concealed thyroid carcinoma which is diagnosed after surgical excision and histopathology of specimen. 26 This delayed diagnosis adversely affects the prognosis of patient and warrants appropriate diagnostic workup before planning and implementing a treatment in patient with multinodular goiter.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Thyroid Carcinoma in Multi Nodular Goiter

Khan¹,

Khan²,

Jogezai³

et al. 2023

PJMHS

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Objective: The objective of this study was to determine the frequency of thyroid carcinoma in patients presenting with multinodular goiter in BMCH. Study Settings: Research was conducted at Department of General Surgery, Bolan Medical Complex Hospital Quetta. Material and Methods: Eighty four patients from both the genders with age between 20-75 years presenting with multinodular goiter since 3 months and meeting inclusion criteria were included in this study after taking informed written consent. All the thyroidectomies were done by consultant general surgeon of the hospital. Post-operatively all the patients were managed as per hospital protocol. Post thyroidectomy specimen was sent for histopathology for diagnosis of thyroid malignancy as per operational definition. All the other findings of study variables such as age, gender, place of residence, BMI (weight in Kg/Height in m2), family history of malignancy, diabetes, hypertension, smoking (>5 cigarettes/day for 2 years) and duration of goiter were noted in a predesigned proforma. Results: The mean age of the patients was 37.4±14.0 years. Majority (n=48, 57.1%) of the patients were aged between 25-50 years, followed by 23 (27.4%) patients aged <25 years and 13 (15.5%) patients aged >50 years. There were 17 (20.2%) male and 67 (79.8%) female patients with a male to female ratio of 1:4. Family history of thyroid malignancy was positive in 11 (13.1%) patients. Thyroid carcinoma was detected in 12 (14.3%) patients with multinodular goiter. When stratified, the frequency of thyroid carcinoma was significantly higher among smokers (29.2% vs. 8.3%; p-value=0.014) and those with positive family history of thyroid cancer (36.4% vs. 11.0%; p-value=0.047). However, no statistically significant difference was observed across various subgroups of patients based on age (p-value=0.978), gender (p-value=1.000), BMI (p-value=1.000), duration of goiter (p-value=0.928), place of residence (p-value=1.000), diabetes (p-value=0.928) and hypertension (p-value=0.858). Conclusion: In the present study, we observed that a substantial proportion of patients with multinodular goiter had concealed thyroid carcinoma particularly smokers and those with positive family history which warrants careful pre-operative evaluation of such patients for thyroid malignancy so that it may be identified well in time and appropriate management may be initiated to improve outcomes in future practice. Keywords: Multinodular Goiter, Thyroid Carcinoma, Positive Family History, Smoking

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Section: Discussionmentioning

confidence: 99%

Frequency of Thyroid Carcinoma in Multi Nodular Goiter

Khan¹,

Khan²,

Jogezai³

et al. 2023

PJMHS

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Clinicopathological study of nodular goiter and thyroid malignancy in Tertiary Care Hospital

Raj

Ray

Vengadesh

et al. 2022

ijhs

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Nodular goiter is a clinicopathological entity characterized by an increased volume of the thyroid gland with formation of nodules. Nodular goiter occurs due to repeated hyperstimulation of thyroid gland due to iodine deficiency, goitrogens, anti-thyroid drugs and genetic defects. Nodular goiter can have different complications which include tracheal compression, retrosternal extension, malignancy and secondary thyrotoxicosis. The present study attempted to study clinical presentation of nodular goiter and to determine the incidence of thyroid cancer in solitary nodular goiter and multinodular goiter in patients admitted in surgery ward of IGMCRI, Puducherry. Retrospective record-based study and single-center study was carried out between January-2011 to December-2019 on consecutive 230 patients admitted in surgery ward with nodular goiter and age above 18 years. Ethics approval was obtained from Institute Ethics Committee (IEC) of IGMCRI. Demographic variables (age and gender), Diagnosis, FNAC, BIOPSY and Carcinoma frequency was assessed in the present study. Data was entered in Microsoft Excel spreadsheet and the data underwent analysis using descriptive statistics involving tables, graphs and bar diagrams. In our study, majority of the study participants (90.4%) belonged to female gender. Maximum patient cases (34.78%) belonged to adult range within 31-40 years.

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Multinodular goitre: a clinicopathological study from Kerala

Cited by 2 publications

References 15 publications

Frequency of Thyroid Carcinoma in Multi Nodular Goiter

Frequency of Thyroid Carcinoma in Multi Nodular Goiter

Clinicopathological study of nodular goiter and thyroid malignancy in Tertiary Care Hospital

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