Multinucleation of spermatozoa and spermatids in infertile men chronically exposed to carbofuran

Gallegos‐Avila, Guadalupe; Áncer‐Rodríguez, Jesús; Niderhauser‐García, Alberto; Ortega‐Martínez, Marta; Jaramillo‐Rangel, Gilberto

doi:10.1016/j.reprotox.2010.03.007

Cited by 12 publications

(7 citation statements)

References 13 publications

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“…The exposure to insecticides such as carbofuran caused cellular‐chromosomal alterations leading to oligozoospermia in men . In view of the evident cytotoxic nature of insecticides, the study of cellular proliferation using rat as animal model became imperative to explore the possible mechanism and dose of drug‐dependent cytotoxicity …”

Section: Introductionmentioning

confidence: 99%

“…7,13 The exposure to insecticides such as carbofuran caused cellular-chromosomal alterations leading to oligozoospermia in men. 14 In view of the evident cytotoxic nature of insecticides, the study of cellular proliferation using rat as animal model became imperative to explore the possible mechanism and dose of drug-dependent cytotoxicity. 15 Although there are potential sources of toxic hazards from IMI, such as the global increase in its use and its persistence in crops, vegetables and fruits and physical contact in pets, there are few investigations on the toxic effects of chronic IMI exposure in human and experimental animal models.…”

Section: Introductionmentioning

confidence: 99%

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Insecticide imidacloprid induces morphological and DNA damage through oxidative toxicity on the reproductive organs of developing male rats

Bal

Nazıroğlu

Türk

et al. 2012

Cell Biochemistry & Function

146

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We investigated whether treatment with imidacloprid would induce morphological changes, DNA fragmentation, antioxidant imbalance and apoptosis in the reproductive system of developing male rats. Twenty-four male rats were included in this 90-day study, starting at 7 days of age. The rats were divided into four groups. The first group was used as control. The second, third and fourth groups received oral 0.5-, 2- and 8-mg/kg imidacloprid, respectively. Serum, sperm and testis samples were collected from all groups at the end of the experimental period. The weights of the epididymis, vesicula seminalis, epididymal sperm concentration, body weight gain, testosterone and reduced glutathione values were lower in the imidacloprid-treated groups than that in the controls. All treated groups had increased lipid peroxidation, fatty acid concentrations and higher rates of abnormal sperm. Apoptosis and fragmentation of seminal DNA were higher in rats treated at the two higher doses of imidacloprid. These results show that this compound has a negative effect on sperm and testis of rats.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Insecticide imidacloprid induces morphological and DNA damage through oxidative toxicity on the reproductive organs of developing male rats

Bal

Nazıroğlu

Türk

et al. 2012

Cell Biochemistry & Function

146

View full text Add to dashboard Cite

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“…Of these 21 studies, 17 were included in this review. Four studies were excluded from the review for one of the following reasons: the study did not assess pesticides as a specific exposure of interest, but rather, evaluated risks based on occupational factors (Vaziri et al, 2011; Tuc et al, 2007); the study did not report any statistical tests between an exposed group and comparison group (Gallegos-Avila et al, 2010); or, the study only presented the results of a stratified analysis and did not report on an overall association between pesticide exposure and sperm parameters (Giwercman et al, 2007). …”

Section: Resultsmentioning

confidence: 99%

Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

2013

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Of continuing concern are the associations between environmental or occupational exposures to pesticides and semen quality parameters. Prior research has indicated that there may be associations between exposure to pesticides of a variety of classes and decreased sperm health. The intent of this review was to summarize the most recent evidence related to pesticide exposures and commonly used semen quality parameters, including concentration, motility and morphology. The recent literature was searched for studies published between January, 2007 and August, 2012 that focused on environmental or occupational pesticide exposures. Included in the review are 17 studies, 15 of which reported significant associations between exposure to pesticides and semen quality indicators. Two studies also investigated the roles genetic polymorphisms may play in the strength or directions of these associations. Specific pesticides targeted for study included dichlorodiphenyltrichloroethane (DDT), hexachlorocyclohexane (HCH), and abamectin. Pyrethroids and organophosphates were analyzed as classes of pesticides rather than as individual compounds, primarily due to the limitations of exposure assessment techniques. Overall, a majority of the studies reported significant associations between pesticide exposure and sperm parameters. A decrease in sperm concentration was the most commonly reported finding among all of the pesticide classes investigated. Decreased motility was also associated with exposures to each of the pesticide classes, although these findings were less frequent across studies. An association between pesticide exposure and sperm morphology was less clear, with only two studies reporting an association. The evidence presented in this review continues to support the hypothesis that exposures to pesticides at environmentally or occupationally relevant levels may be associated with decreased sperm health. Future work in this area should focus on associations between specific pesticides or metabolic products and sperm quality parameters. Analysis of effects of varying genetic characteristics, especially in genes related to pesticide metabolism, also needs further attention.

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“…Sperm quality has been negatively associated with the urinary level of dimethyldithiophosphate (DMDTP), a metabolite of OP in agricultural workers from Villa Juarez, Durango, Mexico [65]. Workers with carbofuran exposure at work for at least 3 years showed multinucleation of spermatozoa and spermatids [45]. Details of Mexican agricultural workers' OP exposure associated with decreased semen quality, sperm DNA damage, etc., are further analysed in the review of Sánchez-Guerra et al, 2011 [100].…”

Section: Alterations In the Sperm Chromatin Structurementioning

confidence: 99%

A Systematic Review of Studies on Genotoxicity and Related Biomarkers in Populations Exposed to Pesticides in Mexico

Sánchez-Alarcón

Milić

Kašuba

et al. 2021

Toxics

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In agricultural activities, pest control is essential, and the most effective method is the use of chemical agents that also represent an important source of exposure to potentially toxic compounds. Pesticides constitute a heterogeneous group of compounds designed specifically to control different pests. Besides measuring their levels or that of their metabolites in air, plasma, serum, blood, urine, etc., some studies reported increased DNA damage levels after occupational or environmental pesticides exposure, evidenced by several cytogenetic biomarkers such as chromosomal aberrations (CA), sister chromatid exchanges (SCE), micronuclei frequency (MN) together with other nuclear abnormalities (NA), alkaline comet assay, but also changes in oxidative stress parameters and miRNA levels. Single or combined, these techniques have also been used in genotoxic biomonitoring studies of workers occupationally exposed to pesticides in Mexico. Despite being a country with great agricultural activity and reported excessive pesticide use, genotoxic studies have been relatively few and, in some cases, contradictory. A review was made of the studies available (published until the end of 2020 on PubMed, Web of Science, Redalyc and Scielo, both in English and Spanish) in the scientific literature that evaluated occupational exposure of human samples to pesticides assessed with DNA damage and related biomarkers in Mexico.

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Multinucleation of spermatozoa and spermatids in infertile men chronically exposed to carbofuran

Cited by 12 publications

References 13 publications

Insecticide imidacloprid induces morphological and DNA damage through oxidative toxicity on the reproductive organs of developing male rats

Insecticide imidacloprid induces morphological and DNA damage through oxidative toxicity on the reproductive organs of developing male rats

Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

A Systematic Review of Studies on Genotoxicity and Related Biomarkers in Populations Exposed to Pesticides in Mexico

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