A design method for a lightweight unmanned sightseeing vehicle frame was proposed based on multi-condition and multi-objective optimization to improve the vehicle’s range and reduce its production cost. First, a finite element model of the frame is established, and its static and dynamic characteristics are analyzed. Then, the wall thickness of the middle beam of the frame was selected as the design variable, and its sensitivity was analyzed. Sample points were generated from the design variables using the Latin hypercube sampling method, and the corresponding response values of the sample points were calculated. A Kriging approximation model was established using the sample points and response values and replaced the actual model for optimization. Finally, a multi-condition and multi-objective optimization mathematical model of the frame was established with the minimum mass, maximum first-order natural frequency, and the minimum stresses under full load bending and torsion conditions as the objectives. The multi-objective genetic algorithm was used for the lightweight design by comparing the fuzzy matter element and analytic hierarchy process methods to select the optimal design and to verify the rationality of the final design scheme. The results show that this method results in an optimized frame meeting the strength requirements under various working conditions and reducing the frame mass by 5.4%.