2021
DOI: 10.3390/ijms22041523
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Multiomics Integration in Skin Diseases with Alterations in Notch Signaling Pathway: PlatOMICs Phase 1 Deployment

Abstract: The high volume of information produced in the age of omics was and still is an important step to understanding several pathological processes, providing the enlightenment of complex molecular networks and the identification of molecular targets associated with many diseases. Despite these remarkable scientific advances, the majority of the results are disconnected and divergent, making their use limited. Skin diseases with alterations in the Notch signaling pathway were extensively studied during the omics er… Show more

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Cited by 11 publications
(11 citation statements)
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“…We searched Sequence Read Archive (SRA) [ 18 ] and Gene Expression Omnibus (GEO) [ 19 ] datasets on 11 July 2022, to find studies involving RNA-Seq of HS tissue samples. The search keywords were: ((Hidradenitis Suppurativa) OR (Acne Inversa)) AND ((RNA-Seq) OR (Transcriptome)) [ 20 ]. After removing duplicates, we included studies that met the criteria of: experiments carried out in HS patients’ skin ( Homo sapiens organism filter); had matching healthy skin controls; and had raw data (fastq files) available for each sample.…”
Section: Methodsmentioning
confidence: 99%
“…We searched Sequence Read Archive (SRA) [ 18 ] and Gene Expression Omnibus (GEO) [ 19 ] datasets on 11 July 2022, to find studies involving RNA-Seq of HS tissue samples. The search keywords were: ((Hidradenitis Suppurativa) OR (Acne Inversa)) AND ((RNA-Seq) OR (Transcriptome)) [ 20 ]. After removing duplicates, we included studies that met the criteria of: experiments carried out in HS patients’ skin ( Homo sapiens organism filter); had matching healthy skin controls; and had raw data (fastq files) available for each sample.…”
Section: Methodsmentioning
confidence: 99%
“…The significance of GSC variants and the disruption in Notch signaling pathways and its targets in HS, is still evolving. Further functional and multiomic studies are required to determine the definitive role of the Notch signaling pathway in skin disease, including HS ( Brandão et al, 2021 ). A working model of HS pathophysiology suggests that underlying genetic variants lead to lower protein expression which becomes functionally relevant under cellular stress mediated by friction (obesity), temperature and dysbiosis ( Pink et al, 2016 ).…”
Section: Discussionmentioning
confidence: 99%
“…Recently, we launched a multi-omics platform (PlatOMICs), an integrative web platform for analyzing omics (or multi-omics) data, to unravel the molecular pathogenesis of human disorders [28]. Unfortunately, since no skin biopsy from our patients was available, we could not apply this integrative analysis.…”
Section: Discussionmentioning
confidence: 99%