Multiomics reveals the mechanism of <i>B. longum</i> in promoting the formation of mixed-species biofilms

Xu, Tao; Xiao, Yumei; Wang, Hongchao; Zhu, Jinlin; Liu, Wenwei; Chen, Wei

doi:10.1039/d3fo01751f

Food Funct.

2023

DOI: 10.1039/d3fo01751f

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Multiomics reveals the mechanism of B. longum in promoting the formation of mixed-species biofilms

Tao Xu¹,

Yumei Xiao²,

Hongchao Wang³

et al.

Abstract: It was found previously that Bifidobacterium longum, Bacteroides ovatus, Enterococcus faecalis, and Lactobacillus gasseri could form biofilm better in vitro and B. longum was the core biofilm-formation-promoting strain in this...

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Cited by 3 publications

References 90 publications

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The gut core microbial species Bifidobacterium longum: Colonization, mechanisms, and health benefits

Xiao,

Huang,

Zhao

et al. 2025

Microbiological Research

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The gut core microbial species Bifidobacterium longum: Colonization, mechanisms, and health benefits

Xiao,

Huang,

Zhao

et al. 2025

Microbiological Research

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The Bifidobacterium-dominated fecal microbiome in dairy calves shapes the characteristic growth phenotype of host

Zhuang,

Liu,

Gao

et al. 2024

npj Biofilms Microbiomes

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The dominant bacteria in the hindgut of calves play an important role in their growth and health, which could even lead to lifelong consequences. However, the identification of core probiotics in the hindgut and its mechanism regulating host growth remain unclear. Here, a total of 1045 fecal samples were analyzed by 16S rRNA gene sequencing from the 408 Holstein dairy calves at the age of 0, 14, 28, 42, 56, and 70 days to characterize the dynamic changes of core taxa. Moreover, the mechanisms of nutrient metabolism of calf growth regulated by core bacteria were investigated using multi-omics analyses. Finally, fecal microbiota transplantation (FMT) in mice were conducted to illustrate the potential beneficial effects of core bacteria. Four calf enterotypes were identified and enterotypes dominated by Bifidobacterium and Oscillospiraceae_UCG-005 were representative. The frequency of enterotype conversion shifted from variable to stable. The close relationship observed between phenotype and enterotype, revealing a potential pro-growth effect of Bifidobacterium, might be implemented by promoting the use of carbohydrate, activating the synthesis of volatile fatty acids, amino acids and vitamin B6, and inhibiting methane production in the hindgut. The FMT results indicated the beneficial effect of Bifidobacterium on host growth and hindgut development. These results support the notion that the Bifidobacterium-dominated fecal microbiome would be an important driving force for promoting the host growth in the early life. Our findings provide new insights into the potential probiotic mining and application strategies to promote the growth of young animals or improve their growth retardation.

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Construction and characterization of stable multi-species biofilms formed by nine core gut bacteria on wheat fiber

Zhang,

Xiao,

Wang

et al. 2024

Food Funct.

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Multiomics reveals the mechanism of B. longum in promoting the formation of mixed-species biofilms

Abstract: It was found previously that Bifidobacterium longum, Bacteroides ovatus, Enterococcus faecalis, and Lactobacillus gasseri could form biofilm better in vitro and B. longum was the core biofilm-formation-promoting strain in this...

Cited by 3 publications

References 90 publications

The gut core microbial species Bifidobacterium longum: Colonization, mechanisms, and health benefits

The gut core microbial species Bifidobacterium longum: Colonization, mechanisms, and health benefits

The Bifidobacterium-dominated fecal microbiome in dairy calves shapes the characteristic growth phenotype of host

Construction and characterization of stable multi-species biofilms formed by nine core gut bacteria on wheat fiber

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