Multiorgan involvement of Behçet’s disease in a young woman

Abstract

Behçet's disease is a rare disorder of unknown etiology that is classified as a systemic vasculitis. The prevalence of the disease is high in countries in the Far East, Mediterranean Basin, and East Asia. Thus, it is also known as the Silk Road Disease. Behçet's disease is characterized by recurrent oral aphthous ulcers, genital sores, and ocular lesions. However, it can present with severe clinical manifestations as a result of cardiovascular system, central nervous system, and gastrointestinal tract involvement. The disease causes serious complications, morbidity, and mortality, especially in male patients with early age onset. Here we present a rare case of Behçet's disease exhibiting multiple organ involvement in a 26-year-old Caucasian female.

Real-Life Data on the Use of Omalizumab in Patients with Severe Asthma and Chronic Urticaria and Mepolizumab in Patients with Severe Asthma: A Retrospective Study

“…Our study also demonstrated that treatment with mepolizumab was associated with a significant reduction in eosinophil counts, which correlated with improved asthma control, as evidenced by higher ACT scores. These findings are consistent with previous studies demonstrating the efficacy of mepolizumab in reducing exacerbation rates and improving asthma control in patients with SEA (5,6,15,29). However, in our research, mepolizumab-treated patients did not exhibit a marked shift in serum total IgE levels.…”

“…A study evaluating response rates, baseline IgE levels, and total IgE levels after omalizumab treatment in patients with CSU found that alterations in IgE levels can predict the outcome of omalizumab treatment (5). In another study, Tamer et al demonstrated that omalizumab reduced serum total eosinophil levels in a significant proportion of CSU patients, indicating that serum eosinophil count might be a valuable marker for guiding treatment decisions (6).…”