Multiparameter Analysis of EEG in Old Wistar Rats after Bilateral Carotid Artery Ligation

Kozhechkin, S. N.; Koshtoyants, O. Ch.; Seredenin, S. B.

doi:10.1007/s10517-009-0577-0

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Immediately after BCCAL, the functional synchronization (CCoh) between different cortical regions significantly decreased in all rats in multiple frequencies (Figure 3C). This result was consistent with findings from previous studies in Wistar rats exposed to BCCAL and in patients with acute thalamic ischemic stroke, both of which showed a decrease of cortical coherence or functional connectivity within the brain after ischemia (Kozhechkin et al 2009; Liu et al 2016). Interestingly, CCoh in SHRSP rats exhibited a dramatic surge (hyperconnectivity) within one hour of cardiac arrest, indicating that the brain is internally super-activated at near-death.…”

Section: Discussionsupporting

confidence: 93%

Surge of Corticocardiac Coupling in SHRSP Rats Exposed to Forebrain Cerebral Ischemia

Tian

Liu

et al. 2018

Preprint

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Sudden death is an important but under-recognized consequence of stroke. Acute stroke can disturb central control of autonomic function, and result in cardiac dysfunction and sudden death. Previous study showed that bilateral common carotid artery ligation (BCCAL) in spontaneously hypertensive stroke-prone rats (SHRSP) is a well-established model for forebrain ischemic sudden death. This study aims to investigate the temporal dynamic changes in electrical activities of the brain and heart and functional interactions between the two vital organs following forebrain ischemia. EEG and ECG signals were simultaneously collected from 9 SHRSP and 8 Wistar-Kyoto (WKY) rats. RR interval and cardiac arrhythmias were analyzed to investigate the cardiac response to brain ischemia. EEG power and coherence (CCoh) analysis were conducted to study the cortical response. Corticocardiac coherence (CCCoh) and directional connectivity (CCCon) were analyzed to determine brain-heart connection. Heart rate variability (HRV) was analyzed to evaluate autonomic functionality. BCCAL resulted in 100% mortality in SHRSP within 14 hours, whereas no mortality was observed in WKY. The functionality of both the brain and the heart were significantly altered in SHRSP compared to WKY after BCCAL. SHRSP rats, but not WKY rats, exhibited intermittent surge of CCCoh, which paralleled the elevated CCCon and reduced HRV, following the onset of ischemia until sudden death. Elevated brain-heart coupling invariably associated with the disruption of the autonomic nervous system and the risk of sudden death. This study may improve our understanding of the mechanism of ischemic stroke-induced sudden death.

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Section: Discussionsupporting

confidence: 93%

Surge of Corticocardiac Coupling in SHRSP Rats Exposed to Forebrain Cerebral Ischemia

Tian

Liu

et al. 2018

Preprint

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Cerebral Activities in Rats within Different Periods after Experimental Unilateral Cerebral Ischemia

Zhang

Hao

et al. 2017

Neurophysiology

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Surge of corticocardiac coupling in SHRSP rats exposed to forebrain cerebral ischemia

Tian

Liu

et al. 2019

Journal of Neurophysiology

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Sudden death is an important but underrecognized consequence of stroke. Acute stroke can disturb central control of autonomic function and result in cardiac dysfunction and sudden death. Previous study showed that bilateral common carotid artery ligation (BCCAL) in the spontaneously hypertensive stroke-prone rat strain (SHRSP) is a well-established model for forebrain ischemic sudden death. This study aims to investigate the temporal dynamic changes in electrical activities of the brain and heart and functional interactions between the two vital organs following forebrain ischemia. EEG and ECG signals were simultaneously collected from nine SHRSP and eight Wistar-Kyoto (WKY) rats. RR interval was analyzed to investigate the cardiac response to brain ischemia. EEG power and coherence (CCoh) analysis were conducted to study the cortical response. Corticocardiac coherence (CCCoh) and directional connectivity (CCCon) were analyzed to determine brain-heart connection. Heart rate variability (HRV) was analyzed to evaluate autonomic functionality. BCCAL resulted in 100% mortality in SHRSP within 14 h, whereas no mortality was observed in WKY rats. The functionality of both the brain and the heart were significantly altered in SHRSP compared with WKY rats after BCCAL. SHRSP, but not WKY rats, exhibited intermittent surge of CCCoh, which paralleled the elevated CCCon and reduced HRV, following the onset of ischemia until sudden death. Elevated brain-heart coupling invariably associated with the disruption of the autonomic nervous system and the risk of sudden death. This study may improve our understanding of the mechanism of forebrain ischemia-induced sudden death. NEW & NOTEWORTHY This study demonstrates a marked surge of corticocardiac coupling in rats dying from focal cerebral ischemia, consistent with our earlier data in rats exposed to fatal asphyxia. Since the bidirectional electrical signal coupling (corticocardiac coherence) and communication (corticocardiac connectivity) between the brain and the heart are only identified in dying animals, they could be used as potential biomarkers to predict the risk of sudden death.

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Multiparameter Analysis of EEG in Old Wistar Rats after Bilateral Carotid Artery Ligation

Cited by 3 publications

References 15 publications

Surge of Corticocardiac Coupling in SHRSP Rats Exposed to Forebrain Cerebral Ischemia

Surge of Corticocardiac Coupling in SHRSP Rats Exposed to Forebrain Cerebral Ischemia

Cerebral Activities in Rats within Different Periods after Experimental Unilateral Cerebral Ischemia

Surge of corticocardiac coupling in SHRSP rats exposed to forebrain cerebral ischemia

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