Multiparametric evaluation by simultaneous PET-MRI examination in patients with histologically proven laryngeal cancer

Cavaliere, Carlo; Romeo, Valeria; Aiello, Marco; Mesolella, Massimo; Iorio, Brigida; Barbuto, Luigi; Cantone, Elena; Nicolai, Emanuele; Covello, M

doi:10.1016/j.ejrad.2016.12.034

Cited by 26 publications

(15 citation statements)

References 26 publications

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“…35 A small study of 16 patients with laryngeal cancer by Cavaliere et al showed that PET/MRI is useful for the primary staging of laryngeal cancer and is comparable to PET/CT. 36 Their study showed a high correlation between imaging findings and endoscopic/histological evaluation for PET/MRI. They also reference the ability of MRI in determining cartilage invasion in suggesting potential for PET/MRI in the evaluation of…”

Section: Accepted Manuscriptmentioning

confidence: 93%

PET/MRI vs PET/CT in Head and Neck Imaging: When, Why, and How?

Ryan

Aaron

Sims

2019

Seminars in Ultrasound, CT and MRI

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The increasing availability of hybrid PET/MRI systems has led to a breadth of new publications and opportunities for use of PET/MRI. While PET/CT has been a valuable tool for oncologic staging, including head and neck malignancy, there are several theoretical and practical advantages a PET/MRI system would have over PET/CT in head and neck imaging. This review article discusses the established role of PET/CT, early evidence for the role of PET/MRI, and protocol considerations for both PET/CT and PET/MRI as they apply to head and neck imaging.

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Section: Accepted Manuscriptmentioning

confidence: 93%

PET/MRI vs PET/CT in Head and Neck Imaging: When, Why, and How?

Ryan

Aaron

Sims

2019

Seminars in Ultrasound, CT and MRI

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“…Bei der Beurteilung zervikaler Läsionen war die PET/MRT der PET/CT geringfügig überlegen, während die PET/CT pulmonale Läsionen zuverlässiger detektierte [58]. In einer kleinen publizierten Fallserie erwies sich die PET/MRT auch im Rahmen des Stagings bei Larynxkarzinomen durch simultane Akquisition metabolischer, funktioneller und morphologischer Informationen als geeignete Modalität der Bildgebung [12]. In einer Studie, in die 17 Patienten mit Kopf-Hals-Tumor eingeschlossen wurden, war die PET/MRT mit einer Sensitivität von 81 %, einer Spezifität von 88 %, einem positiven prädiktiven Wert von 76 % und einem negativen prädiktiven Wert von 93 % der PET/CT ebenbürtig (83 %, 87 %, 73 % und 92 %) [40].…”

Section: Pet/mrtunclassified

PET/CT und PET/MRT bei Tumoren des Kopf-Hals-Bereichs

Grosse

Hellwig

2020

Laryngo-Rhino-Otol

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ZusammenfassungDie Positronen-Emissions-Tomografie (PET) mit 18F-Fluorodesoxyglukose (FDG) in Verbindung mit einer Computertomografie (CT) wird bei speziellen Indikationen in der Diagnostik bei Patienten mit Kopf-Hals-Tumoren eingesetzt. Die Einsatzmöglichkeiten umfassen die Suche nach einem okkulten Primärtumor bei zervikaler Lymphknotenmetastasierung mit zuvor inkonklusiver Diagnostik, das lokale Staging, die Beurteilung des Therapieansprechens nach Radio(chemo)therapie sowie Nachsorgeuntersuchungen, wenn zwischen therapieinduzierten Gewebealterationen und einem Tumorrezidiv differenziert werden muss. Der Erfolg einer Bestrahlung in Hochpräzisionslagerungstechnik (Stereotaxie) bzw. einer intensitätsmodulierten Strahlentherapie scheint durch die Bestimmung des Tumorvolumens unter Einbeziehung der PET/CT verbessert zu werden. Die kombinierte PET/Magnetresonanztomografie (MRT) bietet in diesem Indikationsfeld durch höhere anatomische Detailgenauigkeit Vorteile beim Staging hinsichtlich der Beurteilung des lokalen und lokoregionären Befundes, ist der PET/CT bei der Detektion pulmonaler Metastasen/Zweittumoren jedoch deutlich unterlegen.Auf dem höchstmöglichen Evidenzniveau einer randomisierten Studie wurde gezeigt, dass man bei Patienten mit lokal fortgeschrittenem Kopf-Hals-Tumor bei unauffälliger FDG-PET/CT nach Radiochemotherapie operative Eingriffe ohne Überlebensnachteil vermeiden kann. Die FDG-PET/CT bei Kopf-Hals-Tumoren konnte dadurch vom Gemeinsamen Bundesausschuss (G-BA) als notwendige Leistung für die Versorgung gesetzlich Versicherter anerkannt werden.

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“…where α is the flip angle and can assume values belonging to [2,5,8,12,15,20], and T R = 5.5 ms. Following the method described by Liberman et al, the problem is reformulated as a linear regression system (y = ax + b), as follows:…”

Section: Pet-mri Data Acquisitionmentioning

confidence: 99%

“…In particular, the multimodal, combined PET/MRI examination allows the integration of anatomic and functional information, thus providing higher registration accuracy, when compared with retrospectively coregistered images acquired from separate scanners. Excellent soft tissue contrast can now be combined with the molecular information from PET, and this approach has been shown to provide a comprehensive clinical view for many tissues, including the breast . The imaging parameters derived from the two different modalities can give complementary information with regards to the tumour environment, as they relate to different imaging properties (morphologic and functional).…”

Section: Introductionmentioning

confidence: 99%

“…Excellent soft tissue contrast can now be combined with the molecular information from PET, and this approach has been shown to provide a comprehensive clinical view for many tissues, including the breast. [8][9][10][11][12][13] The imaging parameters derived from the two different modalities can give complementary information with regards to the tumour environment, as they relate to different imaging properties (morphologic and functional). 18 F-fluorodeoxyglucose (FDG)-PET measures the in vivo radiotracer distribution (kBq/mL), which, in the case of FDG-an analogue of glucose-provides functional information based on the increased glucose uptake and glycolysis of cancer cells.…”

Section: Introductionmentioning

confidence: 99%

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A multi‐parametric PET/MRI study of breast cancer: Evaluation of DCE‐MRI pharmacokinetic models and correlation with diffusion and functional parameters

et al. 2018

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The objective of this study is to compare perfusion parameters, as measured by the shutter speed and the Tofts models applied in DCE‐MRI, in malignant breast lesions. Also, to investigate the relationship between perfusion, morphological and functional parameters extracted by the simultaneous acquisition of positron emission tomography (PET) and MRI. 46 patients with histologically confirmed breast cancer were imaged with a 3 T hybrid PET/MRI system, at staging. 18F‐fluorodeoxyglucose (FDG) PET images were acquired simultaneously with MRI, which included DW‐ and DCE‐MRI. Standardized uptake value (SUV), apparent diffusion coefficient (ADC) and pharmacokinetic maps (from the Tofts and shutter speed models) were generated for each primary lesion and a reference, healthy tissue area. Wilcoxon and Spearman tests were used for the statistical analysis. MRI‐derived parameters (perfusion and diffusion) and PET SUVmean were significantly different between tumour and reference tissue (p < 0.05). Significant correlations were found between the two pharmacokinetic models (p < 0.01) and between SUV and pharmacokinetic parameters (Ktrans, kep, ve and τi). No correlation was observed between ADC and SUV, or between ADC and pharmacokinetic parameters. In conclusion, PET/MRI allows for the characterization of primary lesions in breast cancer. Simultaneous analysis of perfusion, morphological and functional markers reveals good agreement between different pharmacokinetic models. Perfusion parameters showed a good correlation with the SUV in breast lesions. In particular, the shutter speed τi was found to be significantly correlated to 18F‐FDG uptake (negative correlation), indicating an association with tumour metabolic mechanisms.

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Multiparametric evaluation by simultaneous PET-MRI examination in patients with histologically proven laryngeal cancer

Cited by 26 publications

References 26 publications

PET/MRI vs PET/CT in Head and Neck Imaging: When, Why, and How?

PET/MRI vs PET/CT in Head and Neck Imaging: When, Why, and How?

PET/CT und PET/MRT bei Tumoren des Kopf-Hals-Bereichs

A multi‐parametric PET/MRI study of breast cancer: Evaluation of DCE‐MRI pharmacokinetic models and correlation with diffusion and functional parameters

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