Multiparametric Magnetic Resonance Imaging/Transrectal Ultrasound Fusion Targeted Biopsy of the Prostate: Preliminary Results of a Prospective Single-Centre Study

Junker, Daniel; Schäfer, Georg; Heidegger, Isabel; Bektic, Jasmin; Ladurner, Michael; Jaschke, Werner; Aigner, Friedrich

doi:10.1159/000365489

Cited by 25 publications

(19 citation statements)

References 23 publications

(29 reference statements)

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“…Further, more recent data illustrate MRI/TRUS fusion-targeted biopsy of suspect MRI lesions as a practicable and safe method in improving prostate cancer diagnosis by "using fewer biopsy cores compared to systematic biopsy" [29] .…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of Transperineal MRI Fusion Biopsy in Comparison to Transrectal Biopsy with Regard to Incidental Histopathological Findings in Transurethral Resection of the Prostate

Dieffenbacher

Popeneciu²,

Radtke³

et al. 2017

Urol Int

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Objective: To investigate the diagnostic accuracy of transperineal MRI/transrectal ultrasound (TRUS) fusion prostate biopsy vs. transrectal prostate biopsy in transurethral resection (TUR) specimen of men undergoing TUR of the prostate (TURP) for symptomatic bladder outlet obstruction. Material and Methods: From a database of 3,509 men receiving prostate biopsy, all those undergoing TURP and negative prostate biopsy (n = 95; 45 transrectal, 50 transperineal fusion) were analysed. TURP specimens were compared with regard to incidental prostate cancer. Results: Pre- and peri-interventional parameters in transrectal vs. fusion biopsy groups for age (65.2 ± 7.8 vs. 65.5 ± 7.3 years; p = 0.84), prostate specific antigen (10.7 ± 8.5 vs. 10.9 ± 8.7 ng/mL; p = 0.93), preoperative prostate volume (72.5 ± 26.1 vs. 71.8 ± 28.1 mL; p = 0.91) and resected weight (43.7 ± 21.9 vs. 41.4 ± 20.7 g; p = 0.61) showed no significant differences. Analysing the TURP specimen, 5 incidental T1a prostate cancers were found (3 Gleason 3 + 3 = 6; 2 Gleason 3 + 4 = 7, all in the transrectal biopsy group). Although, more biopsy cores were obtained in the MRI/TRUS fusion biopsy group (26 cores [interquartile range, IQR 24-28] vs. 14 cores [IQR 12-24], p < 0.01), there was no statistical impact of the obtained number of cores (p = 0.9) on diagnostic accuracy. Statistical analyses revealed significantly better diagnostic accuracy favoring image-guided fusion biopsy (p = 0.02). Conclusions: Our findings showed that a combination of MRI-targeted and systematic transperineal prostate biopsy improves patient safety. This is associated with a combination of transperineal biopsy technique and pre-interventional MRI.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of Transperineal MRI Fusion Biopsy in Comparison to Transrectal Biopsy with Regard to Incidental Histopathological Findings in Transurethral Resection of the Prostate

Dieffenbacher

Popeneciu²,

Radtke³

et al. 2017

Urol Int

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“…MRI is the most accurate imaging modality for the localization of PCa, the only clinical imaging method that depicts the zonal anatomy of the prostate in detail [24]. When PB is targeted to MRI-detected lesion, the diagnosis of PCa and the percentage of significant PCa focus increase [25,26]. van den Bos et al [3] recommends the inclusion of MRI before considering the FT, due to the high negative predictive value (up to 95%) for clinically significant tumours [27].…”

Section: Discussionmentioning

confidence: 99%

Twelve Core Template Prostate Biopsy is an Unreliable Tool to Select Patients Eligible for Focal Therapy

Fumadó¹,

Rosell²,

Juanpere³

et al. 2015

Urol Int

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Introduction: To determine whether unilateral prostate cancer diagnosed at 12-core prostate biopsy harbours relevant prostate cancer foci in contralateral lobe in cases eligible for hemiablative focal therapy. Material and Methods: We analysed 112 radical prostatectomies of unilateral Gleason 6/7 prostate cancer based on prostate biopsy information. The presence of significant prostate cancer foci and/or the index lesion in the contralateral lobe is described. A subanalysis is performed in cases of Gleason score 6 and in cases of very-low-risk prostate cancer. Results: Contralateral prostate cancer was present in 69.6% of cases, fulfilling significant prostate cancer criteria in 33% and being the index lesion in 32%. No significant differences were found when analysing the Gleason 6 group (73% contralateral prostate cancer, 34% significant prostate cancer and 35% index lesion) or the very-low-risk prostate cancer group (80% contralateral prostate cancer, 29% significant prostate cancer and 45% index lesion). Conclusions: The assumption of unilateral prostate cancer based on 12-core template prostate biopsy information is unreliable. In about one third of the cases, there will be focus of significant prostate cancer or the index lesion in the contralateral lobe. This information should be taken into account when hemiablative focal therapies are considered.

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“…Подозрительными в отношении РПЖ при проведении мпМРТ считались гипоинтенсивные на Т2-ВИ очаги, характеризующиеся ограничением диффузии и очаго-вым накоплением контрастного вещества (рис. 3) [21][22][23][24][25][26].…”

Section: материалы и методыunclassified

Targeted histology sampling from atypical small acinar proliferation area detected by repeat transrectal prostate biopsy

Karman¹,

Красный²,

Shimanets³

2017

Cancer Urology

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Multiparametric Magnetic Resonance Imaging/Transrectal Ultrasound Fusion Targeted Biopsy of the Prostate: Preliminary Results of a Prospective Single-Centre Study

Cited by 25 publications

References 23 publications

Diagnostic Accuracy of Transperineal MRI Fusion Biopsy in Comparison to Transrectal Biopsy with Regard to Incidental Histopathological Findings in Transurethral Resection of the Prostate

Diagnostic Accuracy of Transperineal MRI Fusion Biopsy in Comparison to Transrectal Biopsy with Regard to Incidental Histopathological Findings in Transurethral Resection of the Prostate

Twelve Core Template Prostate Biopsy is an Unreliable Tool to Select Patients Eligible for Focal Therapy

Targeted histology sampling from atypical small acinar proliferation area detected by repeat transrectal prostate biopsy

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