Multiparametric MRI evaluation of bone sarcomas in children

Clemente, Emilio J. Inarejos; Navarro, Oscar M.; Navallas, María; Ladera, Enrique; Torner, Ferrán; Suñol, Mariona; Garraus, Moira; March, Jordi Català; Barber, Ignasi

doi:10.1186/s13244-022-01177-9

Cited by 15 publications

(2 citation statements)

References 50 publications

(124 reference statements)

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“…Osteosarcoma and Ewing sarcoma are the most common bone sarcomas in children; in this population, response to chemotherapy can be difficult to evaluate due to the increase in tumor size secondary to necrosis, granulation, and inflammation that demonstrate similar signal intensity and enhancement compared to neoplastic cells. Increased ADC values within the lesion are associated with successful therapy response 98 …”

Section: Dwi In Musculoskeletal Clinical Practicementioning

confidence: 99%

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Applications of Diffusion‐Weighted MRI to the Musculoskeletal System

Raya

Duarte

Wang

et al. 2023

Magnetic Resonance Imaging

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Diffusion‐weighted imaging (DWI) is an established MRI technique that can investigate tissue microstructure at the scale of a few micrometers. Musculoskeletal tissues typically have a highly ordered structure to fulfill their functions and therefore represent an optimal application of DWI. Even more since disruption of tissue organization affects its biomechanical properties and may indicate irreversible damage. The application of DWI to the musculoskeletal system faces application‐specific challenges on data acquisition including susceptibility effects, the low T2 relaxation time of most musculoskeletal tissues (2–70 msec) and the need for sub‐millimetric resolution. Thus, musculoskeletal applications have been an area of development of new DWI methods. In this review, we provide an overview of the technical aspects of DWI acquisition including diffusion‐weighting, MRI pulse sequences and different diffusion regimes to study tissue microstructure. For each tissue type (growth plate, articular cartilage, muscle, bone marrow, intervertebral discs, ligaments, tendons, menisci, and synovium), the rationale for the use of DWI and clinical studies in support of its use as a biomarker are presented. The review describes studies showing that DTI of the growth plate has predictive value for child growth and that DTI of articular cartilage has potential to predict the radiographic progression of joint damage in early stages of osteoarthritis. DTI has been used extensively in skeletal muscle where it has shown potential to detect microstructural and functional changes in a wide range of muscle pathologies. DWI of bone marrow showed to be a valuable tool for the diagnosis of benign and malignant acute vertebral fractures and bone metastases. DTI and diffusion kurtosis have been investigated as markers of early intervertebral disc degeneration and lower back pain. Finally, promising new applications of DTI to anterior cruciate ligament grafts and synovium are presented. The review ends with an overview of the use of DWI in clinical routine.Evidence Level5Technical EfficacyStage 3

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Section: Dwi In Musculoskeletal Clinical Practicementioning

confidence: 99%

“…Increased ADC values within the lesion are associated with successful therapy response. 98 Another clinical application of DWI is PNIs evaluation. PNIs are a relatively common pathology, which in some cases have a diagnostic lag of up to 5 years.…”

Section: Dwi In Musculoskeletal Clinical Practicementioning

confidence: 99%