Multiparametric MRI for characterization of the tumour microenvironment

Hoffmann, Emily; Masthoff, Max; Kunz, Wolfgang G.; Seidensticker, Max; Bobe, Stefanie; Gerwing, Mirjam; Berdel, Wolfgang E.; Schliemann, Christoph; Faber, Cornelius; Wildgruber, Moritz

doi:10.1038/s41571-024-00891-1

Nat Rev Clin Oncol

2024

DOI: 10.1038/s41571-024-00891-1

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Multiparametric MRI for characterization of the tumour microenvironment

Emily Hoffmann,

Max Masthoff,

Wolfgang G. Kunz

et al.

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Cited by 8 publications

References 230 publications

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Nanoprobe Based on Novel NIR‐II Quinolinium Cyanine for Multimodal Imaging

Xu,

Lin,

et al. 2024

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NIR‐II imaging has the advantages of high sensitivity, spatiotemporal resolution, and high penetration depth, thereby serving as a potential alternative to conventional imaging methods. Herein, a novel NIR‐II dye IR‐1010 (λex/λem = 1010/1058 nm) is reported with high quantum yield (3.08%) and good stability, by incorporating p‐methoxyphenyl groups into a quinolinium cyanine dye. Then a multifunctional nanoprobe, termed IUFP NPs, is developed by the incorporation of upconversion (UC) nanoparticles (NPs), perfluoro‐15‐crown‐5‐ether (PFCE), and IR‐1010, to display the novel performance of multimodal imaging. Under the single‐wavelength excitation (980 nm), IUFP NPs simultaneously emit the NIR‐II fluorescence of IR‐1010 and visible UC luminescence of UCNPs, and thus realize the UC imaging for cells, and NIR‐II fluorescence/photoacoustic/19F magnetic resonance imaging for blood vessels, lymph nodes and tumor in mice. This work affords a novel approach to NIR‐II dyes and a general strategy for the design of multimodal imaging probes.

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Nanoprobe Based on Novel NIR‐II Quinolinium Cyanine for Multimodal Imaging

Xu,

Lin,

et al. 2024

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Multiparametric MRI for characterization of the tumour microenvironment

Cited by 8 publications

References 230 publications

Nanoprobe Based on Novel NIR‐II Quinolinium Cyanine for Multimodal Imaging

Nanoprobe Based on Novel NIR‐II Quinolinium Cyanine for Multimodal Imaging

Multiparametric MRI-based Machine Learning Radiomics for Predicting Treatment Response to Transarterial Chemoembolization Combined with Targeted and Immunotherapy in Unresectable Hepatocellular Carcinoma: A Multicenter Study

Engineered SPIONs functionalized with endothelin a receptor antagonist ameliorate liver fibrosis by inhibiting hepatic stellate cell activation

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