Multiparametric MRI for Suspected Recurrent Prostate Cancer after HIFU:Is DCE still needed?

Lotte, R.; Lafourcade, Alexandre; Mozer, Pierre; Conort, Pierre; Barret, Éric; Compérat, Eva; Ezziane, Malek; Guibert, Paul-Hugo Jouve de; Tavolaro, Sebastian; Belin, Lisa; Boudghène, F.; Lucidarme, Olivier; Renard-Penna, Raphaële

doi:10.1007/s00330-018-5352-z

Cited by 24 publications

(14 citation statements)

References 39 publications

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“…These results stand in contrast to the previously published excellent results for mpMRI to detect recurrent disease after HIFU therapy, with sensitivities ranging from 94% to 97% (2,23). However, all previously published studies used transrectal biopsies with or without MRI guiding as a reference standard.…”

Section: Discussioncontrasting

confidence: 77%

“…However, all previously published studies used transrectal biopsies with or without MRI guiding as a reference standard. In the study published by Lotte et al, 24 of 98 patients were excluded because they did not undergo any biopsy, as was probably due to a negative mpMRI result (23). The use of mpMRI to guide biopsy gained wide acceptance and is ideally performed in patients without previous intervention.…”

Section: Discussionmentioning

confidence: 99%

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⁶⁸Ga-PSMA-11 PET/MR Detects Local Recurrence Occult on mpMRI in Prostate Cancer Patients After HIFU

et al. 2019

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High-intensity focused ultrasound (HIFU) is a promising new modality for the treatment of localized prostate cancer (PCa). Follow-up of patients is recommended with biopsies and multiparametric MRI (mpMRI). However, mpMRI in the postinterventional setting is often false-negative. It was our aim to investigate if the new tracer targeting the prostate-specific membrane antigen ( 68 Ga-PSMA-11) could be used to localize recurrent disease with PET/MR in patients with discrepant findings between mpMRI and template biopsies. Methods: Interim analysis was performed of the first 10 patients scanned between September 2016 and May 2018 with positive template biopsy and negative mpMRI after HIFU from an ongoing clinical trial (NCT02265159). All patients underwent 68 Ga-PSMA-11 PET/MRI within 3 mo. Four prostatic quadrants were defined, and for every quadrant suspicion for recurrence was rated on a 5-point Likert scale from definitely no recurrence (1) to highly suspected of recurrence ( 5), with 4 used as a cutoff for suspected disease based on PET/MRI by a masked reader. 68 Ga-PSMA-11 uptake of suspected lesions and background areas was measured with the SUV max . The apparent diffusion coefficient values of lesions and background were given for each segment. PET/MRI scans were compared with the template biopsy results, including corresponding Gleason scores (GS), number of positive cores, and tumor length. Results: The quadrant-based sensitivity, specificity, and positive and negative predictive values for PET/MRI were 55%, 100%, 100%, and 85%, respectively. Patient-based PET/MRI was negative in 4 cases with GS 3 1 4 and a tumor length between 0.1 and 3 mm. All tumor lesions with GS 4 1 3 or higher were detected on PET/MRI. Conclusion: Our preliminary results indicate that 68 Ga-PSMA-11-PET/MR has the potential to localize PCa recurrence after HIFU occult on mpMRI.

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Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

⁶⁸Ga-PSMA-11 PET/MR Detects Local Recurrence Occult on mpMRI in Prostate Cancer Patients After HIFU

et al. 2019

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“…Several other studies have compared a “biparametric reading session” out of a full mp-MRI protocol with the results of the latter in biopsy-naïve men (7–9) as well as in the setting of tumor recurrence assessment after therapy (15). All showed that bp-MRI and mp-MRI had similar or even higher (16) diagnostic accuracy as the full exam, but that bp-MRI has the advantage of being shorter and cheaper.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of a Rapid Biparametric MRI Protocol for Detection of Histologically Proven Prostate Cancer

Obmann

Pahwa

Tabayayong

et al. 2018

Urology

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“…In addition, there is some evidence that DCE sequences may improve planning for focal therapy 22 or staging tumour at the capsule [23][24][25] . Finally, there is a consensus that DCE is useful after radiotherapy or ablation 26,27 , though the size of the effect when high quality DWI is used has been questioned 28,29 . These potential benefits of contrast must be weighed against its expense and potential risk 30 .…”

Section: Application To Clinical Practicementioning

confidence: 99%

Additional Value of Dynamic Contrast-enhanced Sequences in Multiparametric Prostate Magnetic Resonance Imaging: Data from the PROMIS Study

et al. 2020

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Multiparametric MRI for Suspected Recurrent Prostate Cancer after HIFU:Is DCE still needed?

Abstract: • MpMRI has the capability to detect PCa recurrence in post-HIFU monitoring. • The sensitivity of T2w and DWI for detecting PCa recurrence was not improved by DCE. • Readers with different degrees of experience did not improve their performance with DCE.

Cited by 24 publications

References 39 publications

⁶⁸Ga-PSMA-11 PET/MR Detects Local Recurrence Occult on mpMRI in Prostate Cancer Patients After HIFU

⁶⁸Ga-PSMA-11 PET/MR Detects Local Recurrence Occult on mpMRI in Prostate Cancer Patients After HIFU

Diagnostic Accuracy of a Rapid Biparametric MRI Protocol for Detection of Histologically Proven Prostate Cancer

Additional Value of Dynamic Contrast-enhanced Sequences in Multiparametric Prostate Magnetic Resonance Imaging: Data from the PROMIS Study

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Multiparametric MRI for Suspected Recurrent Prostate Cancer after HIFU:Is DCE still needed?

Abstract: • MpMRI has the capability to detect PCa recurrence in post-HIFU monitoring. • The sensitivity of T2w and DWI for detecting PCa recurrence was not improved by DCE. • Readers with different degrees of experience did not improve their performance with DCE.

Cited by 24 publications

References 39 publications

68Ga-PSMA-11 PET/MR Detects Local Recurrence Occult on mpMRI in Prostate Cancer Patients After HIFU

68Ga-PSMA-11 PET/MR Detects Local Recurrence Occult on mpMRI in Prostate Cancer Patients After HIFU

Diagnostic Accuracy of a Rapid Biparametric MRI Protocol for Detection of Histologically Proven Prostate Cancer

Additional Value of Dynamic Contrast-enhanced Sequences in Multiparametric Prostate Magnetic Resonance Imaging: Data from the PROMIS Study

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⁶⁸Ga-PSMA-11 PET/MR Detects Local Recurrence Occult on mpMRI in Prostate Cancer Patients After HIFU

⁶⁸Ga-PSMA-11 PET/MR Detects Local Recurrence Occult on mpMRI in Prostate Cancer Patients After HIFU