Multiparametric Prostate MR Imaging: Impact on Clinical Staging and Decision Making

Duvnjak, Petar; Schulman, Ariel; Holtz, Jamie N; Huang, Jiaoti; Polascik, Thomas J.; Gupta, Rajan T.

doi:10.1016/j.ucl.2018.03.010

Cited by 12 publications

(8 citation statements)

References 56 publications

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“…Accurate preoperative diagnosis of EPE can be highly challenging (46). Postoperative diagnosis of EPE is routinely performed on histopathologic WM sections using criteria from the International Society of Urological Pathology (ISUP) (36), which is regarded as the diagnostic gold standard.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance radiomics for prediction of extraprostatic extension in non-favorable intermediate- and high-risk prostate cancer patients

et al. 2020

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Background To investigate whether magnetic resonance (MR) radiomic features combined with machine learning may aid in predicting extraprostatic extension (EPE) in high- and non-favorable intermediate-risk patients with prostate cancer. Purpose To investigate the diagnostic performance of radiomics to detect EPE. Material and Methods MR radiomic features were extracted from 228 patients, of whom 86 were diagnosed with EPE, using prostate and lesion segmentations. Prediction models were built using Random Forest. Further, EPE was also predicted using a clinical nomogram and routine radiological interpretation and diagnostic performance was assessed for individual and combined models. Results The MR radiomic model with features extracted from the manually delineated lesions performed best among the radiomic models with an area under the curve (AUC) of 0.74. Radiology interpretation yielded an AUC of 0.75 and the clinical nomogram (MSKCC) an AUC of 0.67. A combination of the three prediction models gave the highest AUC of 0.79. Conclusion Radiomic analysis combined with radiology interpretation aid the MSKCC nomogram in predicting EPE in high- and non-favorable intermediate-risk patients.

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Section: Discussionmentioning

confidence: 99%

Magnetic resonance radiomics for prediction of extraprostatic extension in non-favorable intermediate- and high-risk prostate cancer patients

et al. 2020

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“…Given the recent advances that have led to the wider application of MRI for diagnosis and clinical staging of prostate cancer (16), many studies have shown the great correlation between anatomic variables such as preoperative MUL and periurethral supporting structures. In particularly, longer MUL has been considered to be significantly associated with better postoperative continence recovery following RP (13,17,18).…”

Section: Discussionmentioning

confidence: 99%

Association of preoperative urethral parameters on magnetic resonance imaging and immediate recovery of continence following Retzius-sparing robot-assisted radical prostatectomy

Li¹,

Li²,

Lu³

et al. 2020

Transl Androl Urol

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Background: Studies regarding predictive factors of urinary continence following Retzius-sparing radical prostatectomy (RP) is limited. This study was designed to evaluate association of urethral parameters on preoperative magnetic resonance imaging (MRI) and immediate recovery of urinary continence following Retzius-sparing robot assisted radical prostatectomy (RS-RARP).Methods: This retrospective cohort study enrolled 156 patients with clinically localized prostate cancer who underwent MRI before RS-RARP. We measured the following structures on preoperative MRI: minimal residual membranous urethral length (mRUL), peri-urethral sphincter complex (PSC) thickness, urethral wall thickness (UWT), the thicknesses of the levator ani muscle (LAM) and obturator internus muscle (OIM). Immediate urinary continence was defined as patients reported freedom from using safety pad within 7 days after removal of urinary catheter. Patients were divided into two groups according the median of each parameter on MRI. We retrospectively analyzed the patients in term of preoperative clinical factors and postoperative urinary continence.Results: A total of 100 patients (64.1%) reported immediate urinary continence after RS-RARP. Immediate urinary continence was significantly more in patients with longer mRUL (≥8.70 mm) than in patients with shorter mRUL (<8.70 mm; P=0.000). On multivariable analysis, longer mRUL was significantly related to immediate urinary continence after RS-RAPA (odds ratio 8.265; P=0.000). PSC, UWT, LAM and OIM were not associated with immediate urinary continence. Conclusions:Our results firstly demonstrated that preoperative mRUL measured on MRI was an independent predictor of immediate urinary continence following RS-RARP. Therefore, preservation of membranous urethra is still the anatomical basis of better urinary outcome after RS-RARP.

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“…Detailed instructions to interpret the images are available in the PI-RADS v.2 document [1], which unfortunately does not provide any recommendations for definition of radiotherapy targets. The mpMRI can be used for tumor detection, staging, assessment of aggressiveness and treatment monitoring [61,63,64]. For radiotherapy, mpMRI can have a significant impact on the choice of the treatment.…”

Section: Multiparametric Mrimentioning

confidence: 99%

Basic concepts and applications of functional magnetic resonance imaging for radiotherapy of prostate cancer

Olsson

Johansson

Zackrisson

et al. 2019

Physics and Imaging in Radiation Oncology

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Recently, the interest to integrate magnetic resonance imaging (MRI) in radiotherapy for prostate cancer has increased considerably. MRI can contribute in all steps of the radiotherapy workflow from diagnosis, staging, and target definition to treatment follow-up. Of particular interest is the ability of MRI to provide a wide range of functional measures. The complexity of MRI as an imaging modality combined with the growing interest of the application to prostate cancer radiotherapy, emphasize the need for dedicated education within the radiation oncology community. In this context, an overview of the most common as well as a few upcoming functional MR imaging techniques is presented: the basic methodology and measurement is described, the link between the functional measures and the underlying biology is established, and finally relevant applications of functional MRI useful for prostate cancer radiotherapy are given.

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Multiparametric Prostate MR Imaging: Impact on Clinical Staging and Decision Making

Cited by 12 publications

References 56 publications

Magnetic resonance radiomics for prediction of extraprostatic extension in non-favorable intermediate- and high-risk prostate cancer patients

Magnetic resonance radiomics for prediction of extraprostatic extension in non-favorable intermediate- and high-risk prostate cancer patients

Association of preoperative urethral parameters on magnetic resonance imaging and immediate recovery of continence following Retzius-sparing robot-assisted radical prostatectomy

Basic concepts and applications of functional magnetic resonance imaging for radiotherapy of prostate cancer

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