Multiparametric ultrasound for the diagnosis of prostate cancer: Greyscale, shearwave elastography and contrast-enhanced imaging in comparison with radical prostatectomy specimens

EFSUMB Young Investigator Award 2019

“…A total of 50 patients referred for radical prostatectomy were enrolled in this study; my preliminary work on registration allowed me to accurately match the histopathology to the imaging planes and automatically segment the prostate. The first results show that clinical reviewers of mpUS can detect Gleason > 3 + 4 PCa with a sensitivity of 86 %, more than 10 % higher than individual US techniques, without compromising the sensitivity [12]. Moreover, a computeraided detection algorithm, which was developed concurrently, was able to locate significant tumour regions with an ROCcurve area of 0.9 by actively exploiting the automatic zonal segmentation as well as a range of feature radiomics.…”