Multiparticulate formulation approach to pulsatile drug delivery: Current perspectives

Roy, Pranab; Shahiwala, Aliasgar

doi:10.1016/j.jconrel.2008.11.011

Cited by 146 publications

(85 citation statements)

References 29 publications

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“…Before mentioned factors and variables suggest that these design approaches might suffer from limited efficacy in concentrating the active substance at the site of inflammation, preventing drug absorption and systemic exposure to these agents. Moreover, if single unit dosage forms are used, their residence time in GI tract will be under constant threat of persistent diarrhea in IBD patients (Bourgeois, 2005;Chourasia & Jain, 2003;Roy & Shahiwala, 2009). Today it is widely accepted that the delivery of the active substance influences clinical efficacy of the drug product.…”

Section: Conventional Design Strategies For Gi Targetingmentioning

confidence: 99%

Drug Targeting in IBD Treatment – Existing and New Approaches

Goračinova¹,

Dodov²,

Crcarevska³

et al. 2012

Inflammatory Bowel Disease - Advances in Pathogenesis and Management

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Section: Conventional Design Strategies For Gi Targetingmentioning

confidence: 99%

Drug Targeting in IBD Treatment – Existing and New Approaches

Goračinova¹,

Dodov²,

Crcarevska³

et al. 2012

Inflammatory Bowel Disease - Advances in Pathogenesis and Management

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“…The acid solution in turn increases permeability of the hydrated polymer film. The different types of acids that can be used include succinic acid, acetic acid, glutaric acid, tartaric acid, malic acid, or citric acid [57,58].…”

Section: Sigmoidal Release Systemmentioning

confidence: 99%

Recent trends in pulsatile drug delivery systems - A review.

Sharma¹,

Srikanth²,

Uhumwangho³

et al. 2010

Int j Drug delivery

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The purpose of writing this review on pulsatile drug delivery systems (PDDS) is to compile the recent literatures with special focus on the different types and approaches involved in the development of the formulation. PDDS are gaining importance in the field of pharmaceutical technology as these systems deliver the right dose at specific time at a specific site. Some of the disease conditions wherein PDDS are promising include duodenal ulcer, cardiovascular diseases, arthritis, asthma, diabetes, neurological disorder, cancer, hypertension and hypercholesterolemia. PDDS can be classified into time controlled systems wherein the drug release is controlled primarily by the delivery system, stimuli induced PDDS in which release is controlled by the stimuli, such as the pH or enzymes present in the intestinal tract or enzymes present in the drug delivery system and externally regulated system where release is programmed by external stimuli like magnetism, ultrasound, electrical effect and irradiation. This review also summarizes some current PDDS already available in the market. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.

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“…[31,32] Utilization of multiple-unit pellet systems (MUPS) are gaining much more importance over single-unit dosage forms due to their potential advantages: increased bioavailability; predictable, reproducible with short gastric residence time; no risk of dose dumping; reduced risk of local irritation. [33,34] Their main advantage is the flexibility to blend pellets with different compositions or release patterns in order to achieve desired release rate. [35] Among all of the methods for preparation of pellets, extrusion/spheronization technique enables high drug loading.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Single- And Multi-Stage Extrusion Versus Press-Coating Technique in Formulation of Modified-Release Tablets With Theophylline

Petkova¹

2017

WJPPS

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Theophylline has been used in the treatment of respiratory diseases such as asthma and COPD for more than 80 years. It is still a common reported drug, especially for patients with a pronounced clinical picture due to its easy application and low price. The bronchodilating action of theophylline makes the drug useful in the chronic treatment of bronchial asthma, but its narrow therapeutic concentration range and variable pharmacokinetics make dosing management of the drug difficult, which requires utilization of modified release drug dosage forms. One approach to increase the effectiveness of pharmacotherapy is to administer medications while they are most effective and/or tolerable. The principles of chronotherapy can be applied by designing and characterizing drug delivery systems that synchronize drug release with the rhythm of disease activity.Time-controlled release rate can be achieved in many ways, but press-coating technology and multiple-unit pellet systems (MUPS) are one of the most promising techniques. For the purpose of the present study -development of chronopharmaceutical system for treatment of nocturnal asthma, nine formulations tablets prepared from pellets via single-(E1-1-E3-1), two-(E1-2-E3-2) and three-stage (E1-3-E3-3) extrusion and nine formulations single-(T1-1-T3-1), two-(T1-2-T3-2) and three-layered (T1-3-T3-3) press-coated tablets using different polymer blends were prepared, characterized and compared. Formulations with HPMC release slower than formulations with CMC Na and increasing viscosity grade of HPMC, leads to decreasing in release rate. Moreover, fastest is the release rate from single-extruded pellets and slowest -from three-stage extruded pellets. Comparing method of preparationpress-coating technique gives faster release of API than multi-stage extrusion. Among all formulations, formulations E1-3, E2-3, E3-3 and T2-3 exhibit the desired chronotherapeutical release profile -taken before bedtime they deliver API between midnight and early morning hours when asthma incidents are with higher frequency. WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

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Multiparticulate formulation approach to pulsatile drug delivery: Current perspectives

Cited by 146 publications

References 29 publications

Drug Targeting in IBD Treatment – Existing and New Approaches

Drug Targeting in IBD Treatment – Existing and New Approaches

Recent trends in pulsatile drug delivery systems - A review.

Comparison of Single- And Multi-Stage Extrusion Versus Press-Coating Technique in Formulation of Modified-Release Tablets With Theophylline

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