Modern web programming involves coordinating interactions between browser clients and a server. Typically, the interactions in web-based distributed systems are informally described, making it hard to ensure correctness, especially communication safety, i.e. all endpoints progress without type errors or deadlocks, conforming to a specified protocol.We present STScript, a toolchain that generates TypeScript APIs for communication-safe web development over Web-Sockets, and RouST, a new session type theory that supports multiparty communications with routing mechanisms.STScript provides developers with TypeScript APIs generated from a communication protocol specification based on RouST. The generated APIs build upon TypeScript concurrency practices, complement the event-driven style of programming in full-stack web development, and are compatible with the Node.js runtime for server-side endpoints and the React.js framework for browser-side endpoints.RouST can express multiparty interactions routed via an intermediate participant. It supports peer-to-peer communication between browser-side endpoints by routing communication via the server in a way that avoids excessive serialisation. RouST guarantees communication safety for endpoint web applications written using STScript APIs.We evaluate the expressiveness of STScript for modern web programming using several production-ready case studies deployed as web applications.CCS Concepts: • Software and its engineering → Source code generation; • Theory of computation → Distributed computing models.