“…Given the important combinatorial characteristic of the problem, the proposed approach involved coupling a stochastic algorithm, specifically a genetic algorithm, with a discrete-event simulator. Working with similar plants, Corsano et al [15] developed a multiperiod formulation in order to optimize design and production planning simultaneously, where they employed MPCs to solve the production scheduling. Using a mixed-integer non linear programming (MINLP) formulation, a set of possible production campaigns were employed, which were handled by predetermined scheduling constraints, where this approach was applied to a fermentation network.…”