Multiphase hemodynamic simulation of pulsatile flow in a coronary artery

Jung, J.; Lyczkowski, Robert W.; Panchal, C. B.; Hassanein, A.

doi:10.1016/j.jbiomech.2005.06.023

Cited by 126 publications

(133 citation statements)

References 32 publications

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“…Blood segregation in these vessels appears to be weak because the concentration profile has no time to develop. Accordingly, in [92,93], the shear lift force was assumed to be close to zero, and its value in [91] was low, in agreement with weak segregation obtained. The inclusion of leukocytes as the third phase in multiphase models [93] makes it possible to describe the accumulation of these cells in some flow regions even though the validity of treating leukocytes as a continuous phase is doubtful.…”

Section: Blood Fluctuation Temperaturesupporting

confidence: 75%

“…In the Carreau model [9,87,88,[90][91][92][93], the range of viscosity variations is restricted by the limiting values of η 0 (viscosity at rest) and η ∞ (asymptotic viscosity atγ → ∞):…”

Section: Rheological Models Of Bloodmentioning

confidence: 99%

“…The multiphase approach, unlike the single-phase one, does not require to empirically assign particle dispersion coefficients, but it implies an adequate choice of the form of tensors Σ k and the values of exchange coefficients. Such models applied to blood are used to calculate its flow in large vessels with the complicated geometry, such as aorta and coronary arteries [90][91][92][93]. Blood segregation in these vessels appears to be weak because the concentration profile has no time to develop.…”

Section: Blood Fluctuation Temperaturementioning

confidence: 99%

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Segregation of Flowing Blood: Mathematical Description

Tokarev

Panasenko

Ataullakhanov

2011

Math. Model. Nat. Phenom.

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Abstract. Blood rheology is completely determined by its major corpuscles which are erythrocytes, or red blood cells (RBCs). That is why understanding and correct mathematical description of RBCs behavior in blood is a critical step in modelling the blood dynamics. Various phenomena provided by RBCs such as aggregation, deformation, shear-induced diffusion and non-uniform radial distribution affect the passage of blood through the vessels. Hence, they have to be taken into account while modelling the blood dynamics. Other important blood corpuscles are platelets, which are crucial for blood clotting. RBCs strongly affect the platelet transport in blood expelling them to the vessel walls and increasing their dispersion, which has to be considered in models of clotting. In this article we give a brief review of basic modern approaches in mathematical description of these phenomena, discuss their applicability to real flow conditions and propose further pathways for developing the theory of blood flow.

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Section: Blood Fluctuation Temperaturesupporting

confidence: 75%

Section: Rheological Models Of Bloodmentioning

confidence: 99%

Section: Blood Fluctuation Temperaturementioning

confidence: 99%

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Segregation of Flowing Blood: Mathematical Description

Tokarev

Panasenko

Ataullakhanov

2011

Math. Model. Nat. Phenom.

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“…RBC viscosity is high where RBC's accumulation is concentrated. The highest WSS magnitude is observed to be in regions with less accumulation and is higher than in the single-phase flow model [20].…”

Section: Introductionmentioning

confidence: 65%

“…When non-Newtonian models of single-phase or multiphase flows are used, low WSS is observed on the inside curvature of realistic models [4,[18][19][20]. In addition, RBC accumulation in diseased vessels has been reported at the curvature [20,21]. In atherosclerosis, the area of RBC accumulation and local flow characteristics (e.g.…”

Section: Introductionmentioning

confidence: 99%

Multiphase non‐Newtonian effects on pulsatile hemodynamics in a coronary artery

Kim

VandeVord

Lee

2008

Numerical Methods in Fluids

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SUMMARYHemodynamic stresses are involved in the development and progression of vascular diseases. This study investigates the influence of mechanical factors on the hemodynamics of the curved coronary artery in an attempt to identify critical factors of non-Newtonian models. Multiphase non-Newtonian fluid simulations of pulsatile flow were performed and compared with the standard Newtonian fluid models. Different inlet hematocrit levels were used with the simulations to analyze the relationship that hematocrit levels have with red blood cell (RBC) viscosity, shear stress, velocity, and secondary flow. Our results demonstrated that high hematocrit levels induce secondary flow on the inside curvature of the vessel. In addition, RBC viscosity and wall shear stress (WSS) vary as a function of hematocrit level. Low WSS was found to be associated with areas of high hematocrit. These results describe how RBCs interact with the curvature of artery walls. It is concluded that although all models have a good approximation in blood behavior, the multiphase non-Newtonian viscosity model is optimal to demonstrate effects of changes in hematocrit. They provide a better stimulation of realistic blood flow analysis.

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Modeling thrombus formation and growth

Hosseinzadegan

Tafti

2017

Biotech & Bioengineering

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The paper reviews the state-of-the-art in computational modeling of thrombus formation and growth and related phenomena including platelet margination, activation, adhesion, and embolization. Presently, there is a high degree of empiricism in the modeling of thrombus formation. Based on the experimentally observed physics, the review gives useful strategies for predicting thrombus formation and growth. These include determining blood components involved in atherosclerosis, effective blood viscosity, tissue properties, and methods proposed for boundary conditions. In addition to the guidelines, ongoing research on the effect of shear stress on platelet margination, activation and adhesion, and platelet-surface interactions are reviewed. Biotechnol. Bioeng. 2017;114: 2154-2172. © 2017 Wiley Periodicals, Inc.

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Multiphase hemodynamic simulation of pulsatile flow in a coronary artery

Cited by 126 publications

References 32 publications

Segregation of Flowing Blood: Mathematical Description

Segregation of Flowing Blood: Mathematical Description

Multiphase non‐Newtonian effects on pulsatile hemodynamics in a coronary artery

Modeling thrombus formation and growth

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