Multiphoton intrapulse interference IV Ultrashort laser pulse spectral phase characterization and compensation

Lozovoy, Vadim V.; Pastirk, Igor; Dantus, Marcos

doi:10.1364/ol.29.000775

Cited by 405 publications

(255 citation statements)

References 15 publications

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“…The laser pulses were calibrated and compensated to transform-limited (TL) pulses at the position of the sample after a microscope objective by using the multiphoton intrapulseinterference phase scan (MIIPS) method (16,27). This step is critical because it removes unwanted phase deformation introduced by the objective and other optics in the path of the laser beam.…”

Section: Methodsmentioning

confidence: 99%

Use of coherent control methods through scattering biological tissue to achieve functional imaging

Cruz

Pastirk

Comstock

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

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We test whether coherent control methods based on ultrashortpulse phase shaping can be applied when the laser light propagates through biological tissue. Our results demonstrate experimentally that the spectral-phase properties of shaped laser pulses optimized to achieve selective two-photon excitation survive as the laser pulses propagate through tissue. This observation is used to obtain functional images based on selective two-photon excitation of a pH-sensitive chromophore in a sample that is placed behind a slice of biological tissue. Our observation of coherent control through scattering tissue suggests possibilities in multiphoton-based imaging and photodynamic therapy.pulse shaping ͉ two-photon ͉ femtosecond laser ͉ intrapulse interference I nterest in coherent laser control has grown steadily, given its potential for influencing quantum-mechanical laser-molecule interactions (1-7). With the use of pulse shapers and computer learning algorithms, scientists have controlled the excitation of isolated atoms and molecules (8-10) and, more recently, large molecules in solution (11-13). Population transfer between different electronic states of large organic molecules can be maximized or minimized through manipulation of the spectral phase of ultrashort laser pulses (14, 15). The benefits of coherent laser control of large organic molecules can be extended to the biological field through selective two-photon chemical microenvironment probing (16) and microscopy (17). Control of lasermatter interactions could revolutionize biomedical applications. Coherent control schemes, for example, could enhance methods such as two-photon imaging (18, 19), which has provided higher resolution, lower background scattering, and better sample penetration than traditional techniques. Selective two-photon excitation would be desirable for distinguishing healthy from cancerous tissue based on differences in their chemical properties, such as pH, or for activating a photodynamic therapy (PDT) agent only when it is absorbed by cancer cells by using twophoton activated PDT (20). These improvements would be possible only if shaped laser pulses maintain their unique properties as they transmit through scattering biological tissue.Coherent control of laser-induced processes is based on the quantum interference among multiple excitation pathways (3). Progress in this field has been fueled by advances in pulseshaping technology, allowing control of the phase and amplitude across the bandwidth of ultrashort laser pulses (21). Control schemes depend on introducing intricate phase structures on the laser pulses that, by means of constructive and͞or destructive interference, optimize the desired outcome and minimize other pathways. This dependence on the accurate phase structure of the pulse suggests that these methods may not be applicable to situations involving transmission through scattering biological tissue.When a laser beam passes through a turbid scattering medium, its coherence (a property of waves defined as the degree with which w...

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Section: Methodsmentioning

confidence: 99%

Use of coherent control methods through scattering biological tissue to achieve functional imaging

Cruz

Pastirk

Comstock

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

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“…The pulse is compressed at the sample using the multiphoton intrapulse interference phase scan method (Biophotonics Solution, Inc.) to get ∼15 fs pulses. 33 The resulting fluence is 14 µJ/cm 2 per pulse. The optical density (OD) of R26.1 measured in a 1 mm Starna cell is 1.4 at 850 nm (see supplementary material).…”

Section: A Optical Apparatusmentioning

confidence: 99%

Towards quantification of vibronic coupling in photosynthetic antenna complexes

Singh

Westberg

Wang

et al. 2015

The Journal of Chemical Physics

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Photosynthetic antenna complexes harvest sunlight and efficiently transport energy to the reaction center where charge separation powers biochemical energy storage. The discovery of existence of long lived quantum coherence during energy transfer has sparked the discussion on the role of quantum coherence on the energy transfer efficiency. Early works assigned observed coherences to electronic states, and theoretical studies showed that electronic coherences could affect energy transfer efficiency-by either enhancing or suppressing transfer. However, the nature of coherences has been fiercely debated as coherences only report the energy gap between the states that generate coherence signals. Recent works have suggested that either the coherences observed in photosynthetic antenna complexes arise from vibrational wave packets on the ground state or, alternatively, coherences arise from mixed electronic and vibrational states. Understanding origin of coherences is important for designing molecules for efficient light harvesting. Here, we give a direct experimental observation from a mutant of LH2, which does not have B800 chromophores, to distinguish between electronic, vibrational, and vibronic coherence. We also present a minimal theoretical model to characterize the coherences both in the two limiting cases of purely vibrational and purely electronic coherence as well as in the intermediate, vibronic regime. C 2015 AIP Publishing LLC. [http://dx

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“…To avoid this restriction, the self-referencing methods of spectral shearing interferometry, such as SPIDER [3] and SPIRIT [4], are developed. This improvement promotes the SI to the class of the most popular and commercialized methods of accurate measurements on the femtosecond time scale, making it compatible with the FROG [1] and MIIPS [6] techniques, at the expense of a more complicated optical arrangement. Our proposed method of similariton-based SI, along with its self-referencing performance, keeps the simplicity of the principle and configuration of the classic SI.…”

Section: Similariton Based Self-referencing Spectral Interferometry Fmentioning

confidence: 99%

Similariton-Based Spectral Interferometry for Signal Analysis on Femtosecond Time Scale

Mouradian¹,

Zeytunyan²,

Yesayan³

2012

Interferometry - Research and Applications in Science and Technology

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Multiphoton intrapulse interference IV Ultrashort laser pulse spectral phase characterization and compensation

Cited by 405 publications

References 15 publications

Use of coherent control methods through scattering biological tissue to achieve functional imaging

Use of coherent control methods through scattering biological tissue to achieve functional imaging

Towards quantification of vibronic coupling in photosynthetic antenna complexes

Similariton-Based Spectral Interferometry for Signal Analysis on Femtosecond Time Scale

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