Multiphoton plasmon-resonance microscopy

Yelin, Dvir; Oron, Dan; Thiberge, Stephan Y.; Moses, Elisha; Silberberg, Yaron

doi:10.1364/oe.11.001385

Cited by 222 publications

(156 citation statements)

References 24 publications

(31 reference statements)

Supporting

Mentioning

155

Contrasting

Order By: Relevance

“…It is worth noting that in addition to their enhanced TPL, the gold nanorods can provide orientational information as recently demonstrated by Sönnichsen and Alivisatos (28). The gold nanorods are also essentially inert to photobleaching, a quality whose practical consequences are widely appreciated in biophotonic applications (17,28). TPL Autocorrelation Measurements.…”

Section: Resultsmentioning

confidence: 91%

“…For example, Mohamed et al (11) have observed that the quantum efficiency of singlephoton luminescence from gold nanorods is enhanced by a factor of Ͼ1 million under plasmon-resonant conditions. Plasmonresonant TPL is attractive for nonlinear optical imaging of biological samples with 3D spatial resolution (17). Gold nanorods are particularly appealing as TPL substrates because their longitudinal plasmon modes are resonant at near-infrared, where the absorption of water and biological molecules are minimized.…”

mentioning

confidence: 99%

See 1 more Smart Citation

In vitro and in vivo two-photon luminescence imaging of single gold nanorods

Wang

Huff

Zweifel

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

924

884

View full text Add to dashboard Cite

Gold nanorods excited at 830 nm on a far-field laser-scanning microscope produced strong two-photon luminescence (TPL) intensities, with a cos 4 dependence on the incident polarization. The TPL excitation spectrum can be superimposed onto the longitudinal plasmon band, indicating a plasmon-enhanced two-photon absorption cross section. The TPL signal from a single nanorod is 58 times that of the two-photon fluorescence signal from a single rhodamine molecule. The application of gold nanorods as TPL imaging agents is demonstrated by in vivo imaging of single nanorods flowing in mouse ear blood vessels.in vivo imaging ͉ plasmon resonance ͉ multiphoton ͉ nonlinear optics P hotoluminescence from noble metals was first reported in 1969 by Mooradian (1) and later observed as a broad background in surface-enhanced Raman scattering (2). Singlephoton luminescence from metals has been described as a three-step process as follows: (i) excitation of electrons from the d-to the sp-band to generate electron-hole pairs, (ii) scattering of electrons and holes on the picosecond timescale with partial energy transfer to the phonon lattice, and (iii) electron-hole recombination resulting in photon emission (1). Two-photon luminescence (TPL) was characterized by Boyd et al. (3) and is considered to be produced by a similar mechanism as singlephoton luminescence, but the relatively weak TPL signal can be amplified by several orders of magnitude when produced from roughened metal substrates. This amplification is due to a resonant coupling with localized surface plasmons, which are well known to enhance a variety of linear and nonlinear optical properties (4-9).Metal nanoparticles are also capable of photoluminescence, which has been shown to correlate strongly with their welldefined plasmon resonances (10-16). For example, Mohamed et al. (11) have observed that the quantum efficiency of singlephoton luminescence from gold nanorods is enhanced by a factor of Ͼ1 million under plasmon-resonant conditions. Plasmonresonant TPL is attractive for nonlinear optical imaging of biological samples with 3D spatial resolution (17). Gold nanorods are particularly appealing as TPL substrates because their longitudinal plasmon modes are resonant at near-infrared, where the absorption of water and biological molecules are minimized. Moreover, nanorods have larger local field enhancement factors than nanoparticles due to reduced plasmon damping (18). A scanning near-field optical microscopy study of TPL from single nanorods (diameter Ϸ 40 nm) has recently been reported by Imura et al. (16), who observed that the luminescence is greatest at their tips. However, further characterization of TPL from single gold nanorods is needed: the polarization dependence of TPL excitation and emission from nanorods has yet to be defined, as well as the relationship between TPL enhancement and the longitudinal and transverse plasmon modes. These studies can provide a deeper understanding of single-particle TPL and its potential application in nonlinear optical imag...

show abstract

Section: Resultsmentioning

confidence: 91%

mentioning

confidence: 99%

In vitro and in vivo two-photon luminescence imaging of single gold nanorods

Wang

Huff

Zweifel

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

924

884

View full text Add to dashboard Cite

show abstract

“…4 In addition, the high biocompatibility of gold nanoparticles has stimulated their widespread use in the biosciences within the last few years. [5][6][7][8][9][10] Gold particles were used as intramolecular distance rulers, 5 as non bleaching sensors, 6 and as labels for multiphoton microscopy. 10 Simultaneously, novel optical microscopic techniques were developed in order to detect and characterize single nanoparticles.…”

mentioning

confidence: 99%

Orientational Imaging of Subwavelength Au Particles with Higher Order Laser Modes

et al. 2006

View full text Add to dashboard Cite

We present a new method for the imaging of single metallic nanoparticles that provides information about their shape and orientation. Using confocal microscopy in combination with higher order laser modes, scattering images of individual particles are recorded. Gold nanospheres and nonorods render characteristic patterns reflecting the different particle geometries. In the case of nanorods, the scattering patterns also reveal the orientation of the particles. This novel technique provides a promising tool for the visualization of nonbleaching labels in the biosciences.

show abstract

“…Cellular uptake of gold nanorods was visualized by two-photon luminescence microscope. 45,46) To detect two-photon luminescence, femtosecond pulsed laser light is required to observe the uptake; however, it can be expanded to direct imaging of single gold nanorods in vivo. 47) Photoacoustic imaging is a well-known imaging technique for non-invasive imaging of deep tissues, in which gold nanorods act as contrast agent.…”

Section: Fig 3 Normalized Absorption Spectra Of Gold Nanorods Havinmentioning

confidence: 99%

Gold Nanorods as Nanodevices for Bioimaging, Photothermal Therapeutics, and Drug Delivery

Haine

Niidome

2017

Chem. Pharm. Bull.

View full text Add to dashboard Cite

Gold nanorods are promising metals in several biomedical applications such as bioimaging, thermal therapy, and drug delivery. Gold nanorods have strong absorption bands in near-infrared (NIR) light region and show photothermal effects. Since NIR light can penetrate deeply into tissues, their unique optical, chemical, and biological properties have attracted considerable clinical interest. Gold nanorods are expected to act not only as on-demand thermal converters for photothermal therapy but also as mediators of a controlled drug-release system responding to light irradiation. In this review, we discuss current progress using gold nanorods as bioimaging platform, phototherapeutic agents, and drug delivery vehicles.

show abstract

Multiphoton plasmon-resonance microscopy

Cited by 222 publications

References 24 publications

In vitro and in vivo two-photon luminescence imaging of single gold nanorods

In vitro and in vivo two-photon luminescence imaging of single gold nanorods

Orientational Imaging of Subwavelength Au Particles with Higher Order Laser Modes

Gold Nanorods as Nanodevices for Bioimaging, Photothermal Therapeutics, and Drug Delivery

Contact Info

Product

Resources

About