Multiphysics coupling study on the effect of blood flow pulsation in patients with pulsatile tinnitus

Mu, Zhenxia; Sun, Yongkui; Li, Xiaoshuai; Qiu, Xiaoyu; Gao, Bin; Liu, Youjun; Zhao, Peng; Wang, Zhenchang

doi:10.1016/j.bbe.2021.08.008

Cited by 14 publications

(8 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current simulated displacement outcome also conformed to our previous in vivo studies that failed to observe periodical vascular displacements below 0.72 microns before the separation of osseous and vascular walls ( Hsieh et al, 2022b ). Analogously, the vascular displacement gauged at vascular domains without the osseous attachment (brain tissue side) also exhibited a high accordance (at approximately 10-micron level) to previous in vivo findings acquired from the laser displacement sensor measurements ( Hsieh et al, 2022a ), which also matches the results reported by Mu et al (2021b) . Therefore, establishing a sigmoid plate and layers of dura mater in the boundary condition settings can impact the outcomes of CFD simulations and vibroacoustic sources and may greatly limit the displacement of vascular wall.…”

Section: Discussionsupporting

confidence: 88%

“… Tian et al (2017) , Mu et al (2021a) .‘s pioneering works found that the vibroacoustic amplitude of PT ranged from 48.7 to 111.5 dB. Both groups suggested that wall pressure exerted on the sigmoid sinus vessel wall causes vascular displacement, which is a predominant underlying causative factor of vibroacoustic generation of PT; to that end, lowering the sinus wall pressure to reduce vibroacoustic noise generation can be pivotal to quiet PT ( Tian et al, 2019a ; Mu et al, 2021b ). These findings provide a theoretical basis and indication for further surgical development.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of sigmoid plate and dura mater on vascular wall displacement, vibroacoustic/hydroacoustic sources characteristics, and frequency-loudness assessments of venous pulsatile tinnitus: A coupled-computational fluid dynamics study combining transcanal recording investigation

Wang

Hsieh

Xü

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Investigations of pulsatile tinnitus (PT) caused by sigmoid sinus wall anomalies (SSWAs) using computational fluid dynamics (CFD) have recently increased in prevalence. However, accurate modeling of anatomical structures regarding sigmoid plate dehiscence and acoustic sources of PT remains lacking. This study incorporates coupled CFD techniques, micro-computed tomography, and scanning electron microscope to reveal the vibroacoustic and hydroacoustic sources and displacement characteristics of the transverse-sigmoid sinus system. Furthermore, the in vivo transcanal-recording technique combined with ipsilateral internal jugular vein compression was implemented to cross-reference the captured acoustic profile of PT with the calculated results. In this study, the transient state coupled CFD technique was used to calculate the vibroacoustic and hydroacoustic sources. The dehiscent sigmoid plate and periosteal dura mater were then reconstructed. The displacement characteristics and acoustic results were analyzed. The displacement of the vascular wall underneath the dehiscent area was 9.6 times larger than that of the sigmoid plate and 3,617 times smaller than that of the vascular wall without the overlying osseous structures. The peak amplitude of flow-induced vibroacoustic noise was 119.3 dB at 20.2 Hz measured at the transverse sinus. Within the observed 20–1,000 Hz frequency range, the largest peak amplitude of hydroacoustic noise was 80.0 dB at 20.2 Hz located at the jugular bulb region. The simulated results conformed with the in vivo acoustic profile which the major frequency of PT falls within 1,000 Hz. In conclusion, 1) the sigmoid plate and dura mater greatly impact vascular wall displacement, which should not be overlooked in CFD simulations. 2) By incorporating the transcanal recording technique with IJV compression test, the primary frequency of PT was found fluctuating below 1,000 Hz, which matches the frequency component simulated by the current CFD technique; amplitude-wise, however, the peak amplitude of in vivo pulse-synchronous somatosound measures approximately 10 dB, which is comparatively lesser than the CFD results and the subjectively perceived loudness of PT. Thus, the transmission pathway, intramastoid acoustic impedance/amplification effect, and the perceptive threshold of PT require further investigations to minimize the incidence of surgical failure.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Influence of sigmoid plate and dura mater on vascular wall displacement, vibroacoustic/hydroacoustic sources characteristics, and frequency-loudness assessments of venous pulsatile tinnitus: A coupled-computational fluid dynamics study combining transcanal recording investigation

Wang

Hsieh

Xü

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…This finding substantiates the therapeutic effect of endoluminal TSS stenting, which targets the reduction of regional flow velocity and relief of the trans -stenotic pressure gradient ( Mu et al, 2021a ). Previous computational studies found that the flow-induced displacement of the vascular wall could generate vibro-acoustic noise from 48.76 to 116.57 dB ( Tian et al, 2017 ; Mu et al, 2021a , b ). The amplitude of the vibro-acoustic sound surpassed that of the hydroacoustic source when the volume and surface contributions were juxtaposed ( Hsieh et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Retroauricular/Transcranial Color-Coded Doppler Ultrasound Approach in Junction With Ipsilateral Neck Compression on Real-Time Hydroacoustic Variation of Venous Pulsatile Tinnitus

Xiuli

Hsieh

Wang

et al. 2022

Front. Hum. Neurosci.

View full text Add to dashboard Cite

Alterations in dural venous sinus hemodynamics have recently been suggested as the major contributing factors in venous pulsatile tinnitus (PT). Nevertheless, little is known about the association between real-time alterations in hemodynamics and the subjective perception of venous PT. This study aimed to investigate the hydroacoustic correlations among diverticular vortices, mainstream sinus flow, and PT using various Doppler ultrasound techniques. Nineteen venous PT patients with protrusive diverticulum were recruited. The mainstream sinus and diverticular hemodynamics before and after ipsilateral internal jugular vein (IJV) compression were investigated using an innovative retroauricular color-coded Doppler (RCCD) method to examine the correlation between the disappearance of PT and hemodynamic alterations. To reveal the hydroacoustic characteristics of disparate segments of venous return, a computational fluid dynamics (CFD) technique combined with the transcranial color-coded Doppler method was performed. When the ipsilateral IJV was compressed, PT disappeared, as the mean velocity of mainstream sinus flow and diverticular vortex decreased by 51.2 and 50.6%, respectively. The vortex inside the diverticulum persisted in 18 of 19 subjects. The CFD simulation showed that the flow amplitude generated inside the transverse–sigmoid sinus was segmental, and the largest flow amplitude difference was 20.5 dB. The difference in flow amplitude between the mainstream sinus flow and the diverticular flow was less than 1 dB. In conclusion, the sensation of PT is closely associated with the flow of kinetic energy rather than the formation of a vortex, whereby the amplitude of PT is correlated to the magnitude of the flow velocity and pressure gradient. Additionally, the range of velocity reduction revealed by the RCCD method may serve as a presurgical individual baseline curative marker that may potentially optimize the surgical outcomes.

show abstract

“…According to previous computational studies, reducing the fluctuation of the flow velocity alleviates the wall pressure induced by the fluid-structure interaction and reduces the vibroacoustic component of PT. (6,15) Thus, if surgical reduction of the flow velocity is prioritized, the endoluminal stenting technique may be more suitable than the transtemporal technique since expanding the sinus lumen endoluminally is less likely to perniciously augment the intracranial pressure. (7,16,17) In contrast to transverse sinus stenting, using the transtemporal compression technique to reduce the flow velocity should prevent overcompressing the sinus lumen to avoid the iatrogenic cause of intracranial hypertension.…”

Section: Correlation Between Flow Amplitude and Flow Velocity Based O...mentioning

confidence: 99%

“…(4) The perturbance of blood flow and increased central venous pressure near SSWAs have been suggested to augment the acoustic amplitude of PT. (5,6) Vibroacoustic and hydroacoustic generation of sound are two major acoustic sources of venous PT associated with SSWAs. (7,8) As the sigmoid plate becomes dehiscent, the sound of sigmoid sinus vascular wall displacement (vibroacoustic source) secondary to flow impingement and blood flow motion (hydroacoustic source) is transmitted to the inner ear via the air-conduction transmission route.…”

Section: Introductionmentioning

confidence: 99%

Time Series and Mel-frequency Cepstrum Coefficient Analyses of Venous Pulsatile Tinnitus Vascular Sound and Flow Velocity Sensed by Transcranial/Retroauricular Doppler Ultrasound Approaches

Hsieh¹,

Hsieh²,

Wang³

2022

Sensors and Materials

View full text Add to dashboard Cite

Venous pulsatile tinnitus (PT) arises from the motion of blood flow. However, the correlation between flow velocity and amplitude remains undiscovered. In this study, retroauricular colorcoded Doppler (RCCD) and transcranial color-coded Doppler (TCCD) ultrasound examination techniques were deployed to assess the hemoacoustics at the ipsilateral internal jugular vein (IJV), intradiverticular, mainstream sinus, and transverse sinus regions. Auto-and crosscorrelation analyses were used to analyze the correlations between flow velocity and amplitude. Furthermore, the Mel-frequency cepstrum coefficients were calculated, and the Melspectrogram was used to exhibit the human perception of PT. The mainstream sinus flow had the highest coefficient (cross-correlation coefficient = 0.781) among the sensed locations. The cross-correlation coefficient of the IJV was the second largest and close to that of the mainstream sinus flow. The transverse sinus flow had the lowest cross-correlation coefficient. Additionally, the transverse sinus septum was visualized for the first time using the RCCD technique in this study. In conclusion, cross-correlation analysis indicates that the amplitude of vascular sound is highly correlated to the vascular flow velocity. The Mel-spectrogram demonstrates the outcome of the human perception of PT, and its use can be extended to future psychoacoustic studies.

show abstract

Multiphysics coupling study on the effect of blood flow pulsation in patients with pulsatile tinnitus

Cited by 14 publications

References 32 publications

Influence of sigmoid plate and dura mater on vascular wall displacement, vibroacoustic/hydroacoustic sources characteristics, and frequency-loudness assessments of venous pulsatile tinnitus: A coupled-computational fluid dynamics study combining transcanal recording investigation

Influence of sigmoid plate and dura mater on vascular wall displacement, vibroacoustic/hydroacoustic sources characteristics, and frequency-loudness assessments of venous pulsatile tinnitus: A coupled-computational fluid dynamics study combining transcanal recording investigation

Retroauricular/Transcranial Color-Coded Doppler Ultrasound Approach in Junction With Ipsilateral Neck Compression on Real-Time Hydroacoustic Variation of Venous Pulsatile Tinnitus

Time Series and Mel-frequency Cepstrum Coefficient Analyses of Venous Pulsatile Tinnitus Vascular Sound and Flow Velocity Sensed by Transcranial/Retroauricular Doppler Ultrasound Approaches

Contact Info

Product

Resources

About