Multiplanar MRI–CT fusion neuronavigation-guided serial stereotactic biopsy of human brain tumors: proof of a strong correlation between tumor imaging and histopathology by a new technical approach

Kuhn, Susanne; Romeike, Bernd F. M.; Walter, Jan; Kalff, Rolf; Reichart, Rupert

doi:10.1007/s00432-009-0571-y

Cited by 14 publications

(11 citation statements)

References 23 publications

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“…The method was reported only recently (Kuhn et al 2009). In brief, we performed a preoperative navigation MRI using the T1-weighted sequence and intravenous application of gadolinium diethylene triamine penta acetic acid (gadolinium-DTPA).…”

Section: Patientsmentioning

confidence: 97%

Neural cell adhesion molecule isoform 140 declines with rise of WHO grade in human gliomas and serves as indicator for the invasion zone of multiform glioblastomas and brain metastases

Duenisch

Reichart

Mueller³

et al. 2010

J Cancer Res Clin Oncol

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Section: Patientsmentioning

confidence: 97%

Neural cell adhesion molecule isoform 140 declines with rise of WHO grade in human gliomas and serves as indicator for the invasion zone of multiform glioblastomas and brain metastases

Duenisch

Reichart

Mueller³

et al. 2010

J Cancer Res Clin Oncol

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“…The CT images have gain importance as a 3D imaging technique, and image fusion has been applied in applications such as those that use 3D tumor simulations [191]. Similar to MRI, the application of CT images in brain diagnosis and treatment [47,15,135,142] has also been reported. There are several application areas where CT images are considered the prime modality.…”

Section: Computerized Tomographymentioning

confidence: 99%

“…However, the exact radiation levels are not well understood topics, and CT has several other limitations such as limited tissue characterization because of the nature of X-ray probe, restriction of CT scan to transverse slices and practical limitation on number of X-rays that can be produced in the short scan times. Fusion combinations in which CT is one of the main modalities include MRI-CT-PET-SPECT-DSA-MEG [47,135,164], MRI-CT [15,16,17,148,174,179,180,262,61,150,187,151,263,173,154,175,155,156,172,157,158,159,189,64,195,160,196,128,161,178,198,142,165,129,91,167,168,199,242,133,176], SPECT-CT [219,224,…”

Section: Computerized Tomographymentioning

confidence: 99%

Medical image fusion: A survey of the state of the art

2014

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Medical image fusion is the process of registering and combining multiple images from single or multiple imaging modalities to improve the imaging quality and reduce randomness and redundancy in order to increase the clinical applicability of medical images for diagnosis and assessment of medical problems. Multi-modal medical image fusion algorithms and devices have shown notable achievements in improving clinical accuracy of decisions based on medical images. This review article provides a factual listing of methods and summarizes the broad scientific challenges faced in the field of medical image fusion. We characterize the medical image fusion research based on (1) the widely used image fusion methods, (2) imaging modalities, and (3) imaging of organs that are under study. This review concludes that even though there exists several open ended technological and scientific challenges, the fusion of medical images has proved to be useful for advancing the clinical reliability of using medical imaging for medical diagnostics and analysis, and is a scientific discipline that has the potential to significantly grow in the coming years.

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“…We believe that neurosurgeons should strive for as high a diagnostic yield as possible, respecting the possible morbidity or even mortality, although small, the patient confronts when undergoing an intracranial biopsy procedure. Since several authors have shown the benefit of intraoperative histopathologic diagnosis and/or the use of modern intraoperative imaging techniques, improving the diagnostic yield up to as high as 99.2% [4, 14, 20, 22, 31, 32], we implemented intraoperative histopathologic diagnosis into our standardised biopsy procedure in order to possibly improve on our results.…”

Section: Introductionmentioning

confidence: 99%

Towards improving the safety and diagnostic yield of stereotactic biopsy in a single centre

et al. 2010

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BackgroundPreviously, we reported on our single centre results regarding the diagnostic yield of stereotactic needle biopsies of brain lesions. The yield then (1996–2006) was 89.4%. In the present study, we review and evaluate our experience with intraoperative frozen-section histopathologic diagnosis on-demand in order to improve the diagnostic yield.MethodsOne hundred sixty-four consecutive frameless biopsy procedures in 160 patients (group 1, 2006–2010) were compared with the historic control group (group 2, n = 164 frameless biopsy procedures). Diagnostic yield, as well as demographics, morbidity and mortality, was compared. Statistical analysis was performed by Student's t, Mann–Whitney U, Chi-square test and backward logistic regression when appropriate.ResultsDemographics were comparable. In group 1, a non-diagnostic tissue specimen was obtained in 1.8%, compared to 11.0% in group 2 (p = 0.001). Also, both the operating time and the number of biopsies needed were decreased significantly. Procedure-related mortality decreased from 3.7% to 0.6% (p = 0.121). Multivariate analysis only proved operating time (odds ratio (OR), 1.012; 95% confidence interval (CI), 1.000–1.025; p = 0.043), a right-sided lesion (OR, 3.183; 95% CI, 1.217–8.322; p = 0.018) and on-demand intraoperative histology (OR, 0.175; 95% CI, 0.050–0.618; p = 0.007) important factors predicting non-diagnostic biopsies.ConclusionsThe importance of a reliable pathological diagnosis as obtained by biopsy must not be underestimated. We believe that when performing stereotactic biopsy for intracranial lesions, next to minimising morbidity, one should strive for as high a positive yield as possible. In the present single centre retrospective series, we have shown that using a standardised procedure and careful on-demand intraoperative frozen-section analysis can improve the diagnostic yield of stereotactic brain biopsy procedures as compared to a historical series.

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Multiplanar MRI–CT fusion neuronavigation-guided serial stereotactic biopsy of human brain tumors: proof of a strong correlation between tumor imaging and histopathology by a new technical approach

Abstract: Serial stereotactic biopsy is a reliable means. Strong correlations with the imaging characteristics of the lesions could be evaluated.

Cited by 14 publications

References 23 publications

Neural cell adhesion molecule isoform 140 declines with rise of WHO grade in human gliomas and serves as indicator for the invasion zone of multiform glioblastomas and brain metastases

Neural cell adhesion molecule isoform 140 declines with rise of WHO grade in human gliomas and serves as indicator for the invasion zone of multiform glioblastomas and brain metastases

Medical image fusion: A survey of the state of the art

Towards improving the safety and diagnostic yield of stereotactic biopsy in a single centre

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