Multiple acute ischemic strokes as the onset manifestation of acute promyelocytic leukemia

Manea, Maria Mirabela; Dobri, Ana Maria; Dragoș, Dorin; Borsaru, Gabriela; Tuță, Sorin

doi:10.2478/rjim-2018-0021

Cited by 1 publication

(1 citation statement)

References 15 publications

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“…Muñiz AE reported myocardial and cerebral ischemia as the presenting feature in an AML case [7]. Manea et al presented a case of ischemic stroke as the presenting feature in the case of APML [8]. Our case was non-APML; we, however, could not perform a genetic analysis of the case to know the sub-type.…”

Section: Discussionmentioning

confidence: 76%

Ischemic Stroke as the Presenting Feature for Non‐acute Promyelocytic Leukemia Variant of Acute Myeloid Leukemia: A Case Report

Pankaj¹,

Panda²,

Karim³

et al. 2023

Cureus

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Acute myeloid leukemia (AML) patients encounter complications mainly due to their underlying disease or chemotherapy. Although they are at high risk for both hemorrhagic and thrombotic complications, thrombotic vascular complication as an initial manifestation is less common and rarely reported, especially in non-acute promyelocytic leukemia (non-APML). A 58-year-old female with no co-morbidity presented with fever, decreased appetite, headache, and weakness in her left upper and lower limbs. Laboratory findings showed hyperleukocytosis with 90% blast cells and thrombocytopenia (50,000/dl). While investigated and conservatively managed, she developed a seizure and loss of consciousness on the same day and was admitted to the intensive care unit. Computed tomography showed a massive right infarct in the middle cerebral artery territory with a significant midline shift. Flow cytometry indicated the diagnosis of non-APML; chemotherapy, platelet transfusion, unfractionated heparin, mechanical ventilation, and other supportive treatments were started. While managing this case, we faced challenges in decision-making on thrombolysis, craniotomy, and chemotherapy. The case highlights the salient points and dilemmas in managing such an acutely ill patient in critical care.

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Section: Discussionmentioning

confidence: 76%

Ischemic Stroke as the Presenting Feature for Non‐acute Promyelocytic Leukemia Variant of Acute Myeloid Leukemia: A Case Report

Pankaj¹,

Panda²,

Karim³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

Multiple acute ischemic strokes as the onset manifestation of acute promyelocytic leukemia

Abstract: Acute promyelocytic leukemia often manifests with hemorrhagic diathesis, thrombotic events being much rarer. This is the case of a 59-year-old patient with thrombotic cerebro-vascular complications as the onset manifestation of acute promyelocytic leukemia.

Cited by 1 publication

References 15 publications

Ischemic Stroke as the Presenting Feature for Non‐acute Promyelocytic Leukemia Variant of Acute Myeloid Leukemia: A Case Report

Ischemic Stroke as the Presenting Feature for Non‐acute Promyelocytic Leukemia Variant of Acute Myeloid Leukemia: A Case Report

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