Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects

Otani, Iris M.; Bégin, Philippe; Kearney, Clare; Dominguez, Tina; Mehrotra, Anjuli; Bacal, Liane; Wilson, Shruti P.; Nadeau, Kari

doi:10.1186/1710-1492-10-25

Cited by 74 publications

(63 citation statements)

References 28 publications

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“…Several studies, examining food‐allergic patients following OIT, have shown improved quality of life at the end of treatment . However, OIT is a long and challenging treatment and patient motivation and compliance with treatment might be significantly affected by their quality of life.…”

Section: Discussionmentioning

confidence: 99%

Patient quality of life following induction of oral immunotherapy for food allergy

Epstein‐Rigbi

Katz

Goldberg

et al. 2016

Pediatric Allergy Immunology

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Section: Discussionmentioning

confidence: 99%

Patient quality of life following induction of oral immunotherapy for food allergy

Epstein‐Rigbi

Katz

Goldberg

et al. 2016

Pediatric Allergy Immunology

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“…16, 17 Though incidence of food allergy-related mortality is low, avoidance and fear of accidental ingestion significantly impairs quality of life for children with food allergy and their caregivers. 18 …”

Section: Food Allergy Overviewmentioning

confidence: 99%

The future of biologics: Applications for food allergy

Bauer

Manohar

Singh

et al. 2015

Journal of Allergy and Clinical Immunology

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Allergic diseases affects millions worldwide, with growing evidence of an increase in allergy occurrence over the past few decades. Current treatments for allergy include corticosteroids to reduce inflammation and allergen immunotherapy (AIT); however, some individuals experience treatment-resistant inflammation or adverse reactions to these treatments, and neither are currently approved for the treatment of food allergy. There is a dire need for new therapeutic approaches for individuals with poorly controlled atopic diseases and to improve the safety and effectiveness of AIT. Improved understanding of allergy through animal models and clinical trials has unveiled potential targets for new therapies, leading to the development of several biologics to treat allergic diseases. This review focuses on the mechanisms that contribute to allergy, with an emphasis on future targets for biologics for the treatment of food allergy. These biologics include immunotherapy with novel anti-IgE antibodies and analogs, small molecule inhibitors of cell signaling, anti-type 2 cytokine monoclonal antibodies and Th1-promoting adjuvants.

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“…It is known from previous studies that food allergies significantly impair a child's and family's quality of life. 12,18,19 To quantify which aspects are most affected, caregivers were instructed to select specific needs and problems affecting their families.…”

Section: Covariatesmentioning

confidence: 99%

Socioeconomic Disparities in the Economic Impact of Childhood Food Allergy

et al. 2016

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We compared direct medical costs borne by the health care system and out-of-pocket costs borne by families for children with food allergy by socioeconomic characteristics. METHODS:We analyzed cross-sectional survey data collected between November 2011 and January 2012 from 1643 US caregivers with a food-allergic child. We used a 2-part regression model to estimate mean costs and identified differences by levels of household income and race or ethnicity. RESULTS:Children in the lowest income stratum incurred 2.5 times the amount of emergency department and hospitalization costs as a result of their food allergy than higher-income children ($1021, SE ±$209, vs $416, SE ±$94; P < .05). Costs incurred for specialist visits were lower in the lowest income group ($228, SE ±$21) compared with the highest income group ($311, SE ±$18; P < .01) as was spending on out-of-pocket medication costs ($117, SE ± $26, lowest income; $366, SE ±$44, highest income; P < .001). African American caregivers incurred the lowest amount of direct medical costs and spent the least on out-of-pocket costs, with average adjusted costs of $493 (SE ±$109) and $395 (SE ±$452), respectively.CONCLUSIONS: Disparities exist in the economic impact of food allergy based on socioeconomic status. Affordable access to specialty care, medications, and allergen-free foods are critical to keep all food-allergic children safe, regardless of income and race.

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Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects

Cited by 74 publications

References 28 publications

Patient quality of life following induction of oral immunotherapy for food allergy

Patient quality of life following induction of oral immunotherapy for food allergy

The future of biologics: Applications for food allergy

Socioeconomic Disparities in the Economic Impact of Childhood Food Allergy

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