Multiple Anti‐Infective Properties of Selected Plant Species from Zimbabwe

Mangoyi, Rumbidzai; Chitemerere, Tariro; Chimponda, Theresa; Chirisa, Elaine; Mukanganyama, Stanley

doi:10.1002/9781118460566.ch14

Cited by 4 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… Succulent Gavakava (Sh) Aloe (Eng) Leaves Tuberculosis Minor wounds and inflammatory skin disorders. C, E, S Not Evaluated Chimponda and Mukanganyama (2010) ; Maroyi (2013a) ; Mangoyi et al (2014) Asphodelaceae Aloe excelsa Berger Succulent Gavakava (Sh) Tree aloe (Eng) Ihlaba (Nd) Leaves Infusion of ashes Asthma N, W, C, E, S Gelfand et al (1985) Asphodelaceae Aloe spp. Succulent Gavakava (Sh) Aloe (Eng) Icena (Nd) Leaves Infusion Cough N, W, C, E, S Gelfand et al (1985) Asteraceae Artemisia afra Jacq.…”

Section: Methodsmentioning

confidence: 99%

“…var. adoensis Shrub Musikavakadzi (Sh) Bitter leaves, Common bitter leaves (Eng) Leaves Tuberculosis N, C Not Evaluated Chimponda and Mukanganyama (2010) ; Mangoyi et al (2014) Asteraceae Vernonia amygdalina Del. Shrub Dembezeko, Musikavakadzi, Muzhozho, Nyareru (Sh) Tree vernonia, Bitter-tea vernonia (Eng) Inyathelo (Nd) Roots Infusion taken orally Cough Painful uterus, infertility in women, abdominal pain, venereal diseases, cessation of menses, aphrodisiac, weak joints, bilharziasis, fever, diarrhoea and swelling of the body.…”

Section: Methodsmentioning

confidence: 99%

“… Tree Muhacha, Mubuni, Muchakata, Muisha (Sh) Hissing tree, Mobola plum (Eng) Umkhuna (Nd) Roots, leaves and bark Tuberculosis Fever, toothache, wounds, sores and cuts N, W, C, E, S Least Concern Chimponda and Mukanganyama (2010) Clusiaceae Garcinia huillensis Welw Tree Mutunduru (Sh) Granite garcinia, Granite mangosteen (Eng) Leaves Treatment of cough, pneumonia and tuberculosis N, C, E, S Not Evaluated Lower risk – Near threatened (Zambia) Chimponda and Mukanganyama (2010) Clusiaceae Psorospermum febrifugum Spach Tree Mumhinu, Munyamharadzi, Muparadzamusha, Musvasva (Sh) Christmas berry (Eng) Umchithamuzi (Nd) Roots and Leaves Ground into powder and added to porridge Dyspnoea (shortness of breath), pneumonia Head wound, diarrhoea, earache, syphilis and constipation N, C, E, S Gelfand et al (1985) Combretaceae Combretum apiculatum Sond. Tree Muruka, Chikukute, Mudziyaishe, Mugodo, Mugoro, Tsingidzi (Sh) Red bushwillow (English) Umbhondo (Nd) Leaves Cough Snake bites stomach ache N, W, C, E, S Least Concern Maroyi (2013a) ; Mangoyi et al (2014) ; Sharifi-Rad et al (2020) Combretaceae Combretum platypetalum subsp. oatesii (Rolfe) Exell Combretum oatesii Rolfe Shrub Bepu (Sh) Dwarf red c...…”

Section: Methodsmentioning

confidence: 99%

“… N, W, C, E Gelfand et al (1985) Combretaceae Combretum zeyheri Sond. Tree Muruka, Mupembere-kono, Muchenja (Sh) Large-fruited bushwillow (Eng) Umbhondo, Umbula (Nd) Leaves Cough Diarrhoea, rectal prolapse, snake bites and stomach ache N, W, C, E, S Least Concern Mangoyi et al (2014) Combretaceae Terminalia sericea DC. Terminalia velutina sensu Eyles Tree Mangwe, Mukonono, Mususu, Mutabvu (Sh) Silver cluster-Leaves, Silver terminalia (Eng) Umangwe (Nd) Roots Infusion Sore throat Wounds, diarrhoea, abdominal pains, worms in anus, antiemetic, infertility in women, to dilate the birth canal, to prevent abortion, tonic, general body weakness, gonorrhoea, bilharziasis, bleeding from nose and depressed fontanelle.…”

Section: Methodsmentioning

confidence: 99%

“…Merr. Tree Mududwe, Munhunguru, Mutombototo, Mutudza, Mutunguru (Sh) Batoka plum, Governor's plum (Eng) Leaves and Roots Browsed by mouth Eaten raw Cough, chest pains and pneumonia Venereal disease, bilharziasis, diarrhoea N, W, C, E, S Least Concern Viol (2013) ; Mangoyi et al (2014) Heteropyxidaceae Heteropyxis natalensis Harv. Tree Lavender tree, natal lavender (Eng) Mudedede (Venda) Inkunzi, Inkhuzwa (Zulu) Bark, leaves and Roots Colds and respiratory disorders Aphrodisiac, bleeding disorders, bleeding gums, blood purifier, gum infections, toothache, wounds, weaning and menorrhagia E Maroyi (2019f) Hyacinthaceae Urginea sanguinea (Schinz) Jessop Herb Chitupatupa (Sh) Isigenama (Nd) Bulb Decoction taken orally Pneumonia W, C, S Gelfand et al (1985) Kirkiaceae Kirkia acuminata Oliv.…”

Section: Methodsmentioning

confidence: 99%

See 4 more Smart Citations

Medicinal plants used for the management of respiratory diseases in Zimbabwe: Review and perspectives potential management of COVID-19

Nyagumbo¹,

Pote²,

Shopo³

et al. 2022

Physics and Chemistry of the Earth, Parts A/B/C

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Medicinal plants used for the management of respiratory diseases in Zimbabwe: Review and perspectives potential management of COVID-19

Nyagumbo¹,

Pote²,

Shopo³

et al. 2022

Physics and Chemistry of the Earth, Parts A/B/C

View full text Add to dashboard Cite

In vivo and in vitro inhibition of rat liver glutathione transferases activity by extracts from Combretum zeyheri (Combretaceae) and Parinari curatellifolia (Chrysobalanaceae)

Gweshelo

Muswe

Mukanganyama

2016

BMC Complement Altern Med

Self Cite

View full text Add to dashboard Cite

BackgroundParinari curatellifolia and Combretum zeyheri are medicinal plants used in Zimbabwe and other Southern African countries for stomach ailments, fever, body aches, wound healing, cancer and tuberculosis. Glutathione transferases (GSTs) are mammalian enzymes that play a significant role in the detoxification and metabolism of many xenobiotic and endogenous compounds and as such can interact with many exogenous compounds including herbal medicines.The effects of Parinari curatellifolia and Combretum zeyheri leaf extracts on glutathione transferases of male Sprague–Dawley rats were investigated in vivo and in vitro after oral administration of either leaf ethanol or water extracts of each plant.MethodsFor Parinari curatellifolia, 18 male Sprague-Dawley rats were administered with 0, 500 and 1000 mg/kg body weight of the leaf extracts in corn oil or saline. Animals were sacrificed after 96 h and the kidney and liver samples were removed and used to prepare the cytosolic fractions. GST activity was determined using 1-chloro-2, 4-dinitrobezene. For Combretum zeyheri, twenty four male Sprague–Dawley rats were randomly divided into two groups. These two groups were further divided into three groups of four animals each. They were given either the aqueous or ethanol extract at doses of C. zeyheri at 0, 50 mg/kg body weight and 200 mg/kg body weight. The extracts were administered orally by oral gavage for four consecutive days and the rats were sacrificed by cervical dislocation on the fifth day.ResultsIn animals administered with C. zeyheri, GST activity was significantly increased by the 200 mg/kg aqueous extract in the kidneys and livers in vivo whilst the ethanolic extract at 200 mg/kg decreased enzyme activity significantly both organs. Both the ethanol and aqueous extracts inhibited GST activity in vitro with the ethanol extract being more potent inhibitor than ethacrynic acid, a standard GST inhibitor. The increased GST activity in vivo and versus inhibition in vitro suggests that metabolites may be responsible for the effects observed in vivo. For P. curatellifolia, a dose-dependent decrease in GST activity was observed in vivo for the animals given the aqueous extract but no changes were observed with the ethanol extract. There was a concentration-dependent inhibition of cytosolic GSTs when P. curatellifolia leaf extracts in vitro. The ethanol extract of P. curatellifolia exhibited GST-inhibitory activity in the liver with an IC50 value of 12 μg/mL and for ethacrynic acid, the IC50 was found to be 10 μg/mL. This showed that this extract was a potent inhibitor of GSTs in vitro.ConclusionsC. zeyheri had an inductive effect on GST activity when administered in aqueous solution but inhibited GST in vitro whilst P. curatellifolia inhibited GST activity in vivo. Induction of GSTs would be cytoprotective against the toxic effects electrophilic chemicals. Since GSTs are responsible for the synthesis of prostaglandins, the inhibition of GST activity of by these two plants in vivo maybe one of the reasons that make...

show abstract

Medicinal Plants Used for the Treatment and Management of Bilharziasis and Other Parasitic Infections Affecting Humans in Zimbabwe: A Systematic Review

Nyagumbo,

Nyirenda,

Mawere

et al. 2024

Medicinal Plants - Chemical, Biochemical, and Pharmacological Approaches

View full text Add to dashboard Cite

The World Health Organization (WHO) estimated that at least 251.4 million people from 78 countries were in need of preventative care for bilharziasis in 2021. Globally, soil-transmitted helminth infections are present in at least 24% of the world’s population. Tropical and subtropical areas have a wide distribution of infections with a high prevalence in the sub-Saharan Africa. The aim of this study was to document plants that have been traditionally used in Zimbabwe to manage bilharziasis and other parasitic infections. The literature review was based on published papers and abstracts retrieved from the online databases. Books, book chapters, scientific reports and theses from universities in Zimbabwe that were available online were also used in this review. Plants with the reported traditional usage against bilharziasis and other parasitic infections were recorded from the data retrieved. In total, 68 species were used to treat and manage bilharzia and other parasitic infections. Most of these medicinal plants were used to treat and manage schistosomes (fluke or worm). A total of 76.5% of the medicinal plants reported have been scientifically validated and documented to exhibit anthelmintic activity. In conclusion, Zimbabwe has a plethora of medicinal plants that can be used to manage bilharziasis and other parasitic infections.

show abstract

Multiple Anti‐Infective Properties of Selected Plant Species from Zimbabwe

Cited by 4 publications

References 29 publications

Medicinal plants used for the management of respiratory diseases in Zimbabwe: Review and perspectives potential management of COVID-19

Medicinal plants used for the management of respiratory diseases in Zimbabwe: Review and perspectives potential management of COVID-19

In vivo and in vitro inhibition of rat liver glutathione transferases activity by extracts from Combretum zeyheri (Combretaceae) and Parinari curatellifolia (Chrysobalanaceae)

Medicinal Plants Used for the Treatment and Management of Bilharziasis and Other Parasitic Infections Affecting Humans in Zimbabwe: A Systematic Review

Contact Info

Product

Resources

About