Multiple Antibiotic Resistance Patterns of
            <i>Escherichia coli</i>
            Isolates from Swine Farms

Mathew, A. G.; Saxton, Arnold M.; Upchurch, W.G.; Chattin, S E

doi:10.1128/aem.65.6.2770-2772.1999

Cited by 68 publications

(31 citation statements)

References 15 publications

(4 reference statements)

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“…It seems to be likely that genetic resistance elements could be widespread among E. coli even in the absence of antibiotic use (Bilkei et al, 1995). Consistent with literature data (Mathew et al, 1998(Mathew et al, , 1999(Mathew et al, , 2001Bander, 1999), MICs were significantly greater for isolates in antibiotic-using herds (except ceftiofur), indicating that on-farm antibiotic use plays an important role in the susceptibility of resistance of isolates.…”

Section: Discussionsupporting

confidence: 86%

Differences in Antibiotic Resistance inEscherichia coli,Isolated from East‐European Swine Herds With or Without Prophylactic Use of Antibiotics

Docic

Bilkei

2003

Journal of Veterinary Medicine, Series B

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The aim of the study was to compare the resistance patterns of Escherichia coli isolates from pig herds with or without prophylactic use of anti-microbial substances. The presented pig units received either antibiotics or oregano as preventive feed additives. The trial was performed from April to October 2001, in the large 'country-corner', Hungary-Rumania-Serbia. Thirty of 39 evaluated herds suffered E. coli O139 K88 ac or ad LT STb caused losses, the remaining were negative for E. coli O139. Thirteen of the selected 30 herds produced with oregano feed supplementation (Oregpig Pecs, Hungary) antibiotic-free pigs. These units had no history of prophylactic antibiotic use since 1995. The remaining 17 herds routinely used prophylactic antibiotic feed supplementation. In each herd, pigs of four different age groups (suckling piglets, weaners. fattening swine and breeding sows), showing the clinical symptoms of wasting, were investigated. E. coli O139 K88 ac or ad LT STb were tested for their resistance to antibiotics, available in this region. Oregano-fed herds demonstrated high significantly (P < 0.001) lower MICs (microg/ml) for ampicillin, doxycyclin, enrofloxacin, gentamycin, oxytetracyclin and sulfamethacin compared to herds with prophylactic use of antibiotics. Resistance to ceftiofur revealed significant (P < 0.05) differences between the antibiotic- or oregano-treated units. The present results confirm literature data, that prophylactic use of antibiotics likely plays a role in inducing resistance of E. coli and other intestinal bacteria. Thus, imposing greater restrictions on antibiotic use in animal agriculture is likely to reduce but not eliminate the occurrence of resistant isolates.

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Section: Discussionsupporting

confidence: 86%

Differences in Antibiotic Resistance inEscherichia coli,Isolated from East‐European Swine Herds With or Without Prophylactic Use of Antibiotics

Docic

Bilkei

2003

Journal of Veterinary Medicine, Series B

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“…Several attempts have been made to determine the sources of faecal material, including the ratio of faecal coliforms to faecal streptococci (Wiggins et al 1999), detection of specific bacteriophages (Hagedorn et al 1999), study of phenotypic (Stefani 2000), genetic structure and diversity of populations of faecal coliforms (Souza et al 1999;Galland et al 2001;Geornaras et al 2001) and patterns of antibiotic resistance in certain populations of micro-organisms (Gonzalo et al 1989;Mathew et al 1999;Chee-Sanford et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Differentiation of faecal Escherichia coli from humans and animals by multiple antibiotic resistance analysis

Vantarakis

Venieri

Komninou

et al. 2006

Lett Appl Microbiol

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Aims: Multiple antibiotic resistance (MAR) was performed on 128 Escherichia coli isolates, recovered from faecal samples of humans and animals (cattle, goat, sheep) to determine and compare their antibiotic resistance patterns and to evaluate them statistically in order to specify the source of the faecal material. Methods and Results: Disk diffusion method was applied with a selection of antibiotics. Statistical approach was performed with hierarchical cluster analysis (CA), discriminant analysis (DA) and principal component analysis. Comparing human and animal isolates there was significant difference in levels of resistance to all antibiotics tested (P < 0·05) with 46 and 24 distinct resistance patterns for human and animal isolates respectively. CA and DA separated human and animal isolates with a high average rate of correct classification (99·2%), when all animal isolates were pooled together. Conclusions: MAR analysis compared with appropriate statistical evaluation may provide a useful tool for differentiating the human or animal origin of E. coli isolates derived from environmental samples. Subsequently, determination of the source of faecal pollution becomes possible. Significance and Impact of the Study: Determining the source of faecal pollution enables the prediction of possible risk for public health and the application of appropriate management plans for prevention of further contamination.

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“…These bacteria may originate from point sources of contamination, e.g. hospitals, sewage and meat-processing plants, and their abundance and variety are also determined by the extent of use of particular antibiotics and other cleansing agents in speci®c environments (Quednau et al 1998;Austin et al 1999;Mathew et al 1999;Schweizer 1999). The nature of the contribution to this population of AR bacteria by these various sources is, to a large extent unclear, speci®cally for the so-called point sources of bacterial contamination.…”

Section: Introductionmentioning

confidence: 99%

“…The nature of the contribution to this population of AR bacteria by these various sources is, to a large extent unclear, speci®cally for the so-called point sources of bacterial contamination. In a few cases these sources have been partially characterized (Parveen et al 1997;Quednau et al 1998;Mathew et al 1999); however, their effects on their surroundings have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic-resistant Gram-negative bacteria in a virtually closed water reticulation system

2000

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The effect of the ef¯uent from a chicken meat-processing plant on the antibiotic-resistant bacterial pro®le was investigated in an almost closed water reticulation system. Of the 273 faecal coliform isolates 256 (93%) were resistant to one or more of the eight antibiotics tested. The most prevalent isolates were for the b-lactam antibiotics ampicillin and cephalothin followed by the sulphonamides sulphatriad and cotrimoxazole. Eleven different resistance patterns were identi®ed with a single pattern, comprising of ampicillin-, cephalothin-, streptomycin-, sulphatriad-, cotrimoxazole-and tetracyclin-resistant isolates, dominating the meatprocessing ef¯uent. An apparent correlation was observed between the speci®c use of certain antibiotics and the prevalence of the corresponding resistant bacterial isolates. The drugs used to treat the occasional infections, belonging to the b-lactam and sulphonamide group of antibiotics, seemed to have a more pronounced effect on the antibiotic-resistant bacterial pro®le in the primary water source than those drugs used as feed additives, oxytetracyclin and the aminoglycoside¯avomycin.

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Multiple Antibiotic Resistance Patterns of Escherichia coli Isolates from Swine Farms

Cited by 68 publications

References 15 publications

Differences in Antibiotic Resistance inEscherichia coli,Isolated from East‐European Swine Herds With or Without Prophylactic Use of Antibiotics

Differences in Antibiotic Resistance inEscherichia coli,Isolated from East‐European Swine Herds With or Without Prophylactic Use of Antibiotics

Differentiation of faecal Escherichia coli from humans and animals by multiple antibiotic resistance analysis

Antibiotic-resistant Gram-negative bacteria in a virtually closed water reticulation system

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