Multiple Antibiotic–Resistant &lt;EMPH TYPE="ITAL"&gt;Klebsiella&lt;/EMPH&gt; and &lt;EMPH TYPE="ITAL"&gt;Escherichia coli&lt;/EMPH&gt; in Nursing Homes

Wiener, Janis; Quinn, John P.; Bradford, Patricia A.; Goering, Richard V.; Nathan, Catherine; Bush, Karen; Weinstein, Robert A.

doi:10.1001/jama.281.6.517

Cited by 443 publications

(309 citation statements)

References 37 publications

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“…72,73 As mentioned earlier, fluoroquinolone is one of the most common agents linked to this collateral damage, that is, the emergence of various kinds of pathogens. [21][22][23][24][25][27][28][29][30][31][32][33][34][35][36][37][38]71 However, the patterns of emergence vary among studies; no single study has demonstrated the impact of fluoroquinolone use on all of the specific antibiotic-resistant patterns. Differences in the hospital environments, hospital infection control policies, local microbial epidemiology, patient population and treatments, technology, or even study designs may influence the conclusion.…”

Section: Discussionmentioning

confidence: 99%

“…11,13,19 Despite the advantage of antibiotic prophylaxis, 13 a major concern remains on the potential of antibiotic prophylaxis to increase antibacterial resistance, particularly the influence of fluoroquinolone exposure. [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] For example, emergence of fluoroquinoloneresistant bacteria in neutropenic patients receiving fluoroquinolone prophylaxis has been well-documented. [21][22][23][24][25][26][27][28][29] Furthermore, the occurrence of cross-resistant or multiple-drug-resistant (MDR) pathogens, such as an increase in MDR Gram-negative bacteria (GNB), 30,[35][36][37][38] increase in nosocomial methicillin-resistant Staphylococcus aureus infections 31,33,34,38,39 and an emergence of extended spectrum beta-lactamase producers, 32 have all been reported in literature.…”

Section: Introductionmentioning

confidence: 99%

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Impact of bloodstream infections on outcome and the influence of prophylactic oral antibiotic regimens in allogeneic hematopoietic SCT recipients

Liu

Lai

Huang

et al. 2010

Bone Marrow Transplant

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This study aimed to determine the impact of blood stream infections (BSIs) on outcome of allogeneic hematopoietic SCT (HSCT), and to examine the influence of old (nonlevofloxacin-containing) and new (levofloxacin-based) prophylactic antibiotic protocols on the pattern of BSIs. We retrospectively enrolled 246 allogeneic HSCT recipients between January 1999 and June 2006, dividing patients into BSI (within 6 months post-HSCT, n ¼ 61) and non-BSI groups (n ¼ 185). We found that Gramnegative bacteria (GNB) predominated BSI pathogens (54%). Multivariate analyses showed that patients with a BSI, compared with those without, had a significantly greater 6-month mortality (hazard ratio, 1.75; 95% confidence interval, 1.09-2.82; P ¼ 0.021) and a significantly increased length of hospital (LOH) stay (70.8 vs 55.2 days, P ¼ 0.014). Moreover, recipients of old and new protocols did not have a significantly different 6-month mortality and time-to-occurrence of BSIs. However, there were significantly more resistant GNB to third-generation cephalosporins and carbapenem in recipients of levofloxacin-based prophylaxis. Our data suggest that BSIs occur substantially and impact negatively on the outcome and LOH stay after allogeneic HSCT despite antibiotic prophylaxis. Levofloxacin-based prophylaxis, albeit providing similar efficacy to non-levofloxacin-containing regimens, may be associated with increased antimicrobial resistance.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of bloodstream infections on outcome and the influence of prophylactic oral antibiotic regimens in allogeneic hematopoietic SCT recipients

Liu

Lai

Huang

et al. 2010

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…The greater prevalence of resistance to common antibiotics has also been reported by other workers. 15,16 The presence of multidrug resistance may be related to the dissemination of antibiotic resistance among hospital isolates of E. coli. Among aminoglycosides, netillin was found to have an edge over gentamicin and amikacin.…”

Section: Discussionmentioning

confidence: 99%

Virulence factors and drug resistance in <i>Escherichia coli </i>isolated from extraintestinal infections

Sharma¹,

Bhat²,

Shenoy³

2007

Indian J Med Microbiol

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“…Fazem parte da fl ora humana normal, assim como da de diversos animais, e são patógenos oportunistas de importância dentro e fora de hospitais, responsáveis por inúmeras doenças (Rodrigues 1997, Wiener et al 1999. Septicemias nosocomiais provocadas por esses microrganismos ocorrem frequentemente em pacientes entubados e submetidos a aspiração (Branger et al 1998).…”

Section: Discussionunclassified

Disseminação de bactérias patogênicas por formigas (Hymenoptera: Formicidae) em dois hospitais do nordeste do Brasil

Fontana¹,

Wetler²,

Aquino³

et al. 2010

Neotrop. entomol.

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-Nosocomial infections bring a high risk to the health of hospital patients and employees. Ants are common organisms in Brazilian hospitals, where they can act as dispersers of opportunistic microorganisms in places they forage. The occurrence of multi-resistant bacteria carried by ants was analyzed in two public hospitals (HA and HB) in southeastern Bahia, Brazil. In these two hospitals 132 workers belonging to three ant species were collected. The bacteria associated to these ants were identifi ed and their susceptibility to antibiotics was evaluated. More than half (57.3%) of ants collected in HA were associated with some kind of bacteria, with 26.7% of them being opportunist bacteria, while 84,2% of the ants from HB presented associated bacteria growth, with 61.4% of them being opportunist bacteria. Twenty four species of bacteria were isolated. The Gram-positive bacilli of the genus Bacillus were the most frequent, followed by the Gram-positive cocci, Gram-negative bacilli (family Enterobacteriaceae) and Gram-negative non-fermenters bacilli. The profi le of sensitivity of the bacterial isolates to drugs pointed out the existence of multi-resistant isolates carried by ants. For the fi rst time, are reported cases of the same bacterial resistant isolates taken form homospecifi c ant workers that point out the importance of ants to bacteria dissemination and proliferation in a hospital. Our results suggest that the risk of contamination presented by these ants is similar to the one of any other mechanical vector of bacterial dissemination.KEY WORDS: Nosocomial infection, public health, urban ant O êxodo contínuo da população mundial rural e o consequente crescimento acelerado dos conglomerados urbanos provocacom frequência, a redução da qualidade sanitária das cidades, acompanhada da proliferação de vetores de inúmeras doenças. O papel de alguns desses vetores já é bem conhecido, como o dos ratos na propagação de zoonoses como a leptospirose e hantavirose, piolhos de Rickettsia spp., pulgas na transmissão de doenças como a peste bubônica e o tifo murino, e mosquitos na transmissão de inúmeras doenças de importância à saúde pública no Brasil, como a malária e a dengue.

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Multiple Antibiotic–Resistant <EMPH TYPE="ITAL">Klebsiella</EMPH> and <EMPH TYPE="ITAL">Escherichia coli</EMPH> in Nursing Homes

Cited by 443 publications

References 37 publications

Impact of bloodstream infections on outcome and the influence of prophylactic oral antibiotic regimens in allogeneic hematopoietic SCT recipients

Impact of bloodstream infections on outcome and the influence of prophylactic oral antibiotic regimens in allogeneic hematopoietic SCT recipients

Virulence factors and drug resistance in <i>Escherichia coli </i>isolated from extraintestinal infections

Disseminação de bactérias patogênicas por formigas (Hymenoptera: Formicidae) em dois hospitais do nordeste do Brasil

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