Multiple Antibody Response Following Busulfan Therapy1

Abstract

A patient is described who produced antibodies during a period of bone marrow failure produced by prolonged administration of busulfan for chronic myelogenous leukemia. The patient produced antibodies to transfused blood constituents including serum IgA, leukocytes and platelets after minimal stimulus. This case illustrates that under certain conditions the so-called immunosuppressive agents can cause a paradoxical heightening of antibody response.