Multiple asymptomatic papules on the legs

Scleromyxoedema: a cause for unexplained encephalopathy and myositis

“…Scleromyxoedema is characterized by the presence of widespread symmetrical flesh‐coloured papules involving the face, trunk and limbs. It is almost always associated with paraproteinaemia, commonly IgG with gamma light chains, 2,3 although the present case had kappa light chains. In most cases, the paraproteinaemia indicates benign monoclonal gammopathy of uncertain significance 3 .…”

Acral persistent papular mucinosis: a case report and literature review

“…In most cases the lesions slowly increase in number but there are no systemic associations [3]. To our knowledge, thirty‐two cases including two from China have been reported earlier [1, 3–26] which strictly agree with the defined diagnostic criteria of APPM [3]. Besides these 32, another six cases reported in the previous century had similar lesions but did not strictly fit the criteria [3].…”

Acral Persistent Papular Mucinosis in Indian Patient: Rare Presentation with Review of Literature

“…[2] Topical and intralesional corticosteroids have been used with variable success [16,22,25] often without response, [20] and resolved lesions may also recur after corticosteroids are stopped. [25] Spontaneous resolution may occur in LM [3,26] including discrete papular mucinosis, [3] but no tendency to spontaneous resolution was previously reported in APPM, [13][14][15] even after four [27] or twelve years [3] of follow-up. Our patient was not given any treatment and was counselled regarding only cosmetic effect of disease with no systemic involvement and the lesions were asymptomatic and not very apparent.…”

“…APPM is a rarely described subtype of localized lichen myxedematosus (LM). [2,13] Although it was described as a distinct clinical and histological form of cutaneous mucinosis in 1986, [4] suchlesions had been previously described by Montgomery and Underwood in 1953. [11] Diagnostic criteria of APPM were proposed by Harriset al [2] The lesions tend to persist and may increase slowly, but systemic involvement does not occur.…”

“…Aetiology of APPM is still unknown, but thyroid disorders, gammopathy and lupus erythematosus are absent in all localized forms of LM. [2,13] Thetypical histopathology of APPM is presence of focal, well-circumscribed deposit of acid mucopolysacch arides in the papillary and middermis. [2,4,22] These deposits never extend to the deep reticular dermis.…”