Multiple Autoimmune Propensity and B-Non-Hodgkin Lymphoma: Cause or Effect?

Abstract

We report a case of multiple autoimmunity consisting of the presence of autoimmune haemolytic anaemia (AIHA), antimitochondrial antibodies (AMAs), and antiphospholipid antibodies (APLAbs) as the presenting manifestations of an extrahepatic B-non-Hodgkin lymphoma (B-NHL) in a 63-year-old woman. The patient presented with fatigue attributed to severe AIHA. Due to increased serum IgM and γ-GT levels, an investigation for AMA was performed, which proved positive with anti-M2 specificity. A prolongation of activated partial thromboplastin time (aPTT) led to the determination of APLAbs (lupus anticoagulant and other APLAbs) which were also positive. Bone marrow biopsy in combination with immmunohistochemical studies established the diagnosis of lymphoplasmacytic B-NHL. Ten months later, B-NHL was in remission while AMA and APLAbs were still positive. In conclusion, we documented the coexistence of multiple autoimmune reactions together with B-NHL highlighting the possible common pathogenetic pathways of the two entities.

Angioimmunoblastic T-cell lymphoma, combined with antiphospholipid syndrome and autoimmune thrombocytopenia (Case Report)

“…However, this had previously been performed, and there was no other evidence of a different malignant condition having evolved since then. It has been reported that autoimmune phenomena can occur within the context of Non-Hodgkin lymphomas [1]; however, data on a small series of patients suffering from both entities independently from one another has been reported by a French group [2]. The concurrent heparin-induced thrombocytopenia, even cross-reacting with other anticoagulants, is most likely a third independent problem appearing in our patient.…”

Cold Urticaria: A Rare Manifestation of Lymphoma

“…They may sometimes be the first sign of the malignancy [8]. Most of the organs can be targeted by an immune process due to the lymphoproliferative diseases.…”