Multiple autoimmune syndrome with celiac disease

Singh, Harpreet; Jain, Deepak; B, Kiran

doi:10.5114/reum.2016.64911

Cited by 10 publications

(9 citation statements)

References 10 publications

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“…Furthermore, celiac disease found to be part of a multiple auto-immune syndrome (MAS) in several cases. 11 MAS is a condition that is defined by the presence of three or more concomitant auto-immune diseases in a single patient. The pathophysiology of this association is not well described but could expose patients to a higher risk of developing thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Cerebral venous thrombosis as a rare thromboembolic complication of celiac disease: a case report

Bouziane

Arous

Habbal

2020

European Heart Journal - Case Reports

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Background Celiac disease is a digestive inflammatory syndrome with several complications. It is associated with coagulation and platelets abnormalities leading to thromboembolic events. Cerebral venous thrombosis is an exceptional localization of thrombosis in celiac disease and could be life-threatening. Case summary A 17-year-old female patient with history of celiac disease and not following a gluten-free diet, checked in to the emergency department for a sudden, 2-week-old, and deteriorating, onset of intense headache and muscle weakness. The cerebral computed tomography-scan showed bilateral fronto-parietal hypodensity with micro-bleeds. We investigated using a cerebral magnetic resonance imaging that revealed superior longitudinal sinus thrombosis and right transverse and sigmoid sinuses thrombosis, along with right haematoma and ischaemic areas. The patient was prescribed anticoagulation therapy. Follow-ups over a 2-year period confirmed a favourable outcome and a complete regression of symptoms. Discussion Evolution of celiac disease could be associated with several complications. Eighty-five percent of patients is potentially exposed to thromboembolic events due to the hypercoagulability state of the disease and different coagulation and fibrinolysis abnormalities (e.g. hyperhomocysteinaemia, protein C and S deficiencies, vitamin K and B deficiencies). Cerebral venous thrombosis is a rare thromboembolic localization. Anticoagulation is efficient in most cases though endovascular treatment might be required.

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Section: Discussionmentioning

confidence: 99%

Cerebral venous thrombosis as a rare thromboembolic complication of celiac disease: a case report

Bouziane

Arous

Habbal

2020

European Heart Journal - Case Reports

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“…A study conducted in 2016 by Harpreet et al [7] described a 32-year-old woman who presented with multiple symmetrical articular pains and stiffness accompanied by hypothyroidism and microcytic hypochromic anaemia as shown by a serum haemoglobin level of 8.2 mg/dl. MAS with coeliac disease has also been described.…”

Section: Discussionmentioning

confidence: 99%

Autoimmune Haemolytic Anaemia and Multiple Autoimmune Syndrome

Sereshki

Almasi

Behnam

et al. 2019

European Journal of Case Reports in Internal Medicine

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The presence of different autoimmune disorders in the same individual is called multiple autoimmune syndrome (MAS). One of these co-occurring conditions is autoimmune haemolytic anaemia (AIHA), which is characterized by the production of autoantibodies against red blood cells due to immune system malfunction and which results in severe tissue oxygenation disturbance. AIHA is not uncommon but occurs rarely in MAS; if it does, MAS is then classified as MAS type III. Herein, we describe a case of MAS type III including AIHA which was successfully treated with hydrocortisone with gradual resolution of symptoms. LEARNING POINTS The co-occurrence of multiple autoimmune disorders in the same individual is called multiple autoimmune syndrome (MAS). Autoimmune haemolytic anaemia is not uncommon but rarely occurs in MAS. The presence of one autoimmune disease should alert the physician to the possible presence of others.

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“…Patients with a single autoimmune disease are at 25% risk of development of other autoimmune diseases [13]. Many studies in children have reported an association between CD and various autoimmune diseases.…”

Section: Celiac Disease and Other Autoimmune Diseasesmentioning

confidence: 99%