Multiple avascular necrosis of bone and polyarticular septic arthritis in patients with systemic lupus erythematosus

Galindo, María; Mateo, Isabel; Pablos, José L.

doi:10.1007/s00296-004-0444-2

Cited by 24 publications

(19 citation statements)

References 23 publications

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“…Multifocal osteonecrosis is defined as disease affecting three or more joints, and its overall incidence is estimated to be around 3% among patients diagnosed as having osteonecrosis [ 1 ]. The risk factors associated with multifocal osteonecrosis are corticosteroid treatment [ 1 ], alcohol abuse [ 2 , 3 ], coagulation disorders [ 4 ], connective tissue disorders including systemic lupus erythematosus (SLE) [ 5 ], inflammatory bowel disease [ 6 ], renal transplantation [ 1 ], underlying malignancies [ 7 ], HIV infection [ 8 ], sickle cell disease [ 9 ], and trauma [ 10 ]. Although chronic alcohol intake is a common cause of osteonecrosis, multifocal osteonecrosis is relatively rare in this context.…”

Section: Introductionmentioning

confidence: 99%

Multifocal Osteonecrosis Secondary to Chronic Alcohol Ingestion

Matsumoto

Ogawa

Akiyama

2015

Case Reports in Orthopedics

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Multifocal osteonecrosis is a relatively rare disorder with an estimated incidence of around 3% among patients diagnosed as having osteonecrosis. Multifocal osteonecrosis is caused by the several conditions including corticosteroid treatment, coagulation disorders, connective tissue disorders including systemic lupus erythematosus (SLE), inflammatory bowel disease, renal transplantation, and underlying malignancies. Alcohol abuse is one of the risk factors for osteonecrosis, and alcohol-induced osteonecrosis is 5% among all the osteonecrosis. Furthermore, the overall incidence of alcohol-induced multifocal osteonecrosis was approximately 6% among all the osteonecrosis induced by the alcohol. Therefore, here, we report an extremely rare case of alcohol-induced multifocal osteonecrosis involving three joints (two knees and one hip) and review the related literature.

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Section: Introductionmentioning

confidence: 99%

Multifocal Osteonecrosis Secondary to Chronic Alcohol Ingestion

Matsumoto

Ogawa

Akiyama

2015

Case Reports in Orthopedics

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“…Infection plays an important role in mortality and morbidity of SLE patients and the major concerns in diagnosis and treatment of such, mainly when it occurs in the joints [3,5]. Joint infection is one of the leading causes of acute joint pain and swelling in patients with SLE.…”

Section: Discussionmentioning

confidence: 99%

Salmonella Osteomyelitis in a Patient With Systemic Lupus Erythematosus

Toosi¹,

Dehnavi²,

Asgardoon³

et al. 2018

Clin Infect Immun

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Although infections occur commonly in patients with systemic lupus erythematosus (SLE), Salmonella osteomyelitis is rarely reported in SLE patients. Hereby, we described an SLE case which was complicated by Salmonella infection. The reported case was referred to our center with right knee swelling and pain from 2 months before her admission. Because of no responding to appropriate therapy and high C reactive protein (CRP) level, we suspected to other differential diagnosis such as infection. Knee MRI was in favor of osteomyelitis of distal femur and proximal tibia. It was approved by the bone specimen culture. Patient's symptoms were significantly better 1 month after debridement surgery and antibiotic therapy. This case indicates that rare infection site such as bone with unusual organism causes should be considered in SLE patients coming with unexpected symptoms looking like prolonged joint swelling and pain despite appropriate therapy.

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“…[18,19] Septic arthritis has been reported to occur in during the follow-up osteonecrosis especially immunocompromised patient due to lupus or organ transplantation. [20][21][22][23] On the other hand, in situations with bacteriemia, hematogenously distributed bacteria possessing the specific ability to bind to bone collagen and, has capacity to trigger osteomyelitis. [24,25] The bacteria adhere directly to the cartilage matrix and they form obstructive emboli in the metaphyseal vasculature causes local ischemia and necrosis.…”

Section: Discussionmentioning

confidence: 99%

Multifocal osteonecrosis and osteomyelitis in a liver transplant recipient

Ucer¹

2015

FNG & Bilim Tıp Dergisi

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Osteonecrosis is the destruction of bone as a result of temporary or permanent cessation of blood supply to the bones. Trauma, drugs, infections, hypercoagulability and solid organ transplantation are the most common causes. Osteonecrosis has been reported in many case series after renal, liver and cardiac transplantation; mainly in areas adjacent to the joints, especially on hip. Here, we are reporting multifocal osteonecrosis with osteomyelitis including diaphyseal region of the tibia in a patient with liver transplantation.

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Multiple avascular necrosis of bone and polyarticular septic arthritis in patients with systemic lupus erythematosus

Abstract: Active SLE patients with aPL antibodies on high-dose CS seem at high risk of developing multiple AVN complicated by infection. Avascular necrosis and bone or joint infection by S. aureus in these patients is a major complication that leads to severe joint destruction and disability.

Cited by 24 publications

References 23 publications

Multifocal Osteonecrosis Secondary to Chronic Alcohol Ingestion

Multifocal Osteonecrosis Secondary to Chronic Alcohol Ingestion

Salmonella Osteomyelitis in a Patient With Systemic Lupus Erythematosus

Multifocal osteonecrosis and osteomyelitis in a liver transplant recipient

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