Multiple bee stings

Robertson, Mark

doi:10.1111/j.1442-2026.1998.tb00672.x

Cited by 3 publications

(8 citation statements)

References 22 publications

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“…We consider these results of particular importance since the increasing number of patients admitted to emergency departments and intensive care units makes the BV massive envenomation a health problem (Mitchell 2006;Robertson 1998). These patients are usually monitored for the levels of several blood parameters and are treated supportively (Mitchell 2006;Robertson 1998).…”

Section: Single Application Of Bv In Sublethal Dosesmentioning

confidence: 98%

Electrophysiological and Structural Aspects in the Frontal Cortex After the Bee (Apis mellifera) Venom Experimental Treatment

Florea

Puica²,

Vintan

et al. 2011

Cell Mol Neurobiol

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The aim of this study is to evaluate the bioelectrical and structural-functional changes in frontal cortex after the bee venom (BV) experimental treatments simulating both an acute envenomation and a subchronic BV therapy. Wistar rats were subcutaneously injected once with three different BV doses: 700 μg/kg (T(1) group), 2100 μg/kg (T(3) group), and 62 mg/kg (sublethal dose-in T(SL) group), and repeated for 30 days with the lowest dose (700 μg/kg-in T(S) group). BV effects were assessed by electrophysiological, histological, histochemical, and ultrastructural methods. Single BV doses produced discharges of negative and biphasic sharp waves, and epileptiform spike-wave complexes. The increasing frequency of these elements suggested a dose-dependent neuronal hyperexcitation or irritation. As compared to the lower doses, the sublethal dose was responsible for a pronounced toxic effect, confirmed by ultrastructural data in both neurons and glial cells that underwent extensive, irreversible changes, triggering the cellular death. Subchronic BV treatment in T(S) group resulted in a slower frequency and increased amplitude of cortical activity suggesting neuronal loss. However, neurons were still stimulated by the last BV dose. Structural-functional data showed a reduced cellular density in frontal cortex of animals in this group, while the remaining neurons displayed both specific (stimulation of neuronal activity) and unspecific modifications (moderate alterations to necrotic phenomena). Molecular mechanisms involved in BV interactions with the nervous tissue are also discussed. We consider all these data very important for clinicians who manage patients with multiple bee stings, or who intend to set an appropriate BV therapy.

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Section: Single Application Of Bv In Sublethal Dosesmentioning

confidence: 98%

Electrophysiological and Structural Aspects in the Frontal Cortex After the Bee (Apis mellifera) Venom Experimental Treatment

Florea

Puica²,

Vintan

et al. 2011

Cell Mol Neurobiol

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“…Serious systemic illness and death from bee stings is a rare occurrence and more often is caused by IgE‐mediated anaphylaxis rather than toxic envenomation (lethal dose is ~20 stings/kg body weight) …”

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confidence: 99%

“…Other hymenoptera such as wasps, hornets, bull ants and yellow jackets can also cause death by toxic envenomation in sufficient numbers . Two canine cases of bull‐ant envenomation have been described in Australia …”

mentioning

confidence: 99%

“…S erious systemic illness and death from bee stings is a rare occurrence and more often is caused by IgE-mediated anaphylaxis rather than toxic envenomation (lethal dose is~20 stings/kg body weight). 1 In Australia, significant bee stings are from the European honeybee (Apis mellifera), which is the only species used in the honey industry, and fatal mass attacks in humans are very rare. 1 This is in contrast to the situation in South America where thousands of cases have been reported, increasingly associated with the more aggressive, hybrid Africanised honeybee (A. mellifera adansonii or A. scutellata).…”

mentioning

confidence: 99%

“…1 In Australia, significant bee stings are from the European honeybee (Apis mellifera), which is the only species used in the honey industry, and fatal mass attacks in humans are very rare. 1 This is in contrast to the situation in South America where thousands of cases have been reported, increasingly associated with the more aggressive, hybrid Africanised honeybee (A. mellifera adansonii or A. scutellata). 2 The syndrome of mass envenomation has been well described in humans [3][4][5][6][7][8][9][10][11][12] and dogs.…”

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confidence: 99%

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Mass envenomation of a mare and foal by bees

Lewis¹,

Racklyeft²

2014

Aust Veterinary J

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Production of the First Effective Hyperimmune Equine Serum Antivenom against Africanized Bees

et al. 2013

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Victims of massive bee attacks become extremely ill, presenting symptoms ranging from dizziness and headache to acute renal failure and multiple organ failure that can lead to death. Previous attempts to develop specific antivenom to treat these victims have been unsuccessful. We herein report a F(ab)´2-based antivenom raised in horse as a potential new treatment for victims of multiple bee stings. The final product contains high specific IgG titers and is effective in neutralizing toxic effects, such as hemolysis, cytotoxicity and myotoxicity. The assessment of neutralization was revised and hemolysis, the primary toxic effect of these stings, was fully neutralized in vivo for the first time.

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Multiple bee stings

Cited by 3 publications

References 22 publications

Electrophysiological and Structural Aspects in the Frontal Cortex After the Bee (Apis mellifera) Venom Experimental Treatment

Electrophysiological and Structural Aspects in the Frontal Cortex After the Bee (Apis mellifera) Venom Experimental Treatment

Mass envenomation of a mare and foal by bees

Production of the First Effective Hyperimmune Equine Serum Antivenom against Africanized Bees

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