Multiple Bilateral Pulmonary “Fungus Balls” in an Immunocompetent Patient Unsuitable for Surgical Treatment: Efficacy of Azoles Treatment

Capone, Amedeo; Bella, Stefano Di; Chinello, Pierangelo; Chiappetta, D.; Campoli, Caterina; Petrosillo, Nicola

doi:10.1007/s11046-013-9639-y

Cited by 5 publications

(7 citation statements)

References 7 publications

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“…The diagnosis of pulmonary mycetoma is confirmed by positive sputum culture for aspergillus or candida species and a positive aspergillus precipitin test. These patients respond to various antifungal drugs [ 10 ]. All these features were not seen in the reported patient.…”

Section: Case Discussionmentioning

confidence: 99%

Multiple Mycetoma Lung Secondaries from Knee Eumycetoma: An Unusual Complication

Mohamed¹,

Din²,

Fahal³

2016

PLoS Negl Trop Dis

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Section: Case Discussionmentioning

confidence: 99%

Multiple Mycetoma Lung Secondaries from Knee Eumycetoma: An Unusual Complication

Mohamed¹,

Din²,

Fahal³

2016

PLoS Negl Trop Dis

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“…In aspergilloma patients unfit for surgical treatment VRCZ might help relief symptoms . One successful VRCZ treatment in a sepsis patient with co‐infection of Aspergillus and Staphylococcus epidermidis has been reported …”

Section: Treatment Options and Prognosismentioning

confidence: 99%

“…113 In aspergilloma patients unfit for surgical treatment VRCZ might help relief symptoms. 114 One successful VRCZ treatment in a sepsis patient with co-infection of Aspergillus and Staphylococcus epidermidis has been reported. 115 The most common adverse effects of VRCZ are visual and digestive disturbance and elevated liver enzymes.…”

Section: Antifungalsmentioning

confidence: 99%

Chronic pulmonary aspergillosis

Schweer,

Bangard,

Hekmat

et al. 2013

Mycoses

101

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Summary Chronic pulmonary aspergillosis (CPA) is a group of consuming diseases usually presenting with prolonged and relapsing cough, dyspnoea and weight loss. Acute symptoms such as haemoptysis and bronchial or pulmonary haemorrhage may occasionally occur. CPA affects patients with underlying pulmonary conditions, for example, chronic obstructive pulmonary disease or mycobacteriosis or common immunosuppressive conditions such as diabetes. Precise epidemiology is unknown, and while prevalence is considered low the chronic and relapsing nature of the disease challenges the treating physician. Diagnostics largely rely on serologic Aspergillus precipitins and findings on thoracic computed tomography. The latter are manifold comprising cavity formation, pleural involvement and sometimes aspergilloma. Other markers for aspergillosis are less helpful, in part due to the non‐ or semi‐invasive nature of these forms of Aspergillus infection. Various antifungals were shown to be effective in CPA treatment. Azoles are the most frequently applied antifungals in the outpatient setting, but are now compromised by findings of Aspergillus resistance. Long‐term prognosis is not fully elucidated and may be driven by the underlying morbidities. Prospective registry‐type studies may be suitable to systematically broaden our CPA knowledge base. This article gives an overview of the available literature and proposes a clinical working algorithm for CPA management.

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“…Anti-fungal medication (voriconazole, itraconazole) was a safe and effective modality and should be considered if surgery contraindicated [27–29]. But in the case of both medical and surgical treatment were ineffective or contraindicated in massive hemoptysis due to aspergilloma, intervention treatment was an alternative therapy with the success rate was 40.0% [30].…”

Section: Discussionmentioning

confidence: 99%

Hemoptysis from complex pulmonary aspergilloma treated by cavernostomy and thoracoplasty

et al. 2019

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BackgroundIn high-risk patients with complex pulmonary aspergilloma but unable for lung resection, cavernostomy and thoracoplasty could be performed. This study aimed to evaluate this surgery compared two compressing materials.MethodsA total of 63 in high-risk patients who suffered from hemoptysis due to complex pulmonary aspergilloma and underwent cavernostomy and thoracoplasty surgery from November 2011 to September 2018 at Pham Ngoc Thach hospital were evaluated prospectively studied. Patients were allocated to two groups: the table tennis ball group and tissue expander group. We evaluated at the time of before operation, 6 months and 24 months after operation.ResultsTuberculosis was the most common comorbidity diseases in both groups. Upper lobe occupied almost in location. Hemoptysis symptoms plunged from time to time. Statistically significant Karnofsky score was observed in both groups. Postoperative pulmonary functions (FVC and FEV1) have remained in both groups at all time points. The remarkable results were no deaths related to surgery and low complications both short and long-term. There was no statistical significance between two groups in operative time, blood loss during operation, ICU length-stay time. Four patients died because of co-morbidity in 24 months follow-up.ConclusionCavernostomy and thoracoplasty was safe and effective surgery for the treatment of complex pulmonary aspergilloma with hemoptysis in high-risk patients. No mortality related to surgery and low complications were recorded. The was no inferiority when compared two compressing materials .

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Multiple Bilateral Pulmonary “Fungus Balls” in an Immunocompetent Patient Unsuitable for Surgical Treatment: Efficacy of Azoles Treatment

Cited by 5 publications

References 7 publications

Multiple Mycetoma Lung Secondaries from Knee Eumycetoma: An Unusual Complication

Multiple Mycetoma Lung Secondaries from Knee Eumycetoma: An Unusual Complication

Chronic pulmonary aspergillosis

Hemoptysis from complex pulmonary aspergilloma treated by cavernostomy and thoracoplasty

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