Multiple bile-duct hamartomas (Von Meyenburg complexes)

Andrés, M. Civera; Alegre, Santiago Vivas; Castañón, R. Rueda

doi:10.4321/s1130-01082006000400009

Cited by 4 publications

(2 citation statements)

References 1 publication

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“…Our analysis includes these 139 patients. Tables 3 , 4 , 5 [ 2 , 7 , 8 , 11 - 90 ] summarise the data from all of the cases studied.…”

Section: Reviewmentioning

confidence: 99%

Biliary Duct Hamartomas: A Systematic Review

Sheikh¹,

Nguyen²,

Leyba³

et al. 2022

Cureus

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Biliary duct hamartomas are benign intrahepatic bile duct lesions. Despite being primarily incidental findings on imaging, these lesions can provide a diagnostic conundrum due to their shared characteristics with malignant tumors. The goal of this systematic review is to offer a thorough clinical profile of biliary duct hamartomas. There were 139 cases of biliary duct hamartomas identified in a structured systematic review of the literature. Patient demographics, clinical presentation, significant laboratory and imaging data, diagnostic modalities, treatment choices, and outcomes were all studied and reported. Biliary duct hamartomas present with mild symptoms and laboratory abnormalities, and while being visible on imaging, the results are non-specific and may require biopsy in case of red flag signs such as weight loss and a progressive increase in the size of the lesion. Furthermore, there are currently no published guidelines for the treatment of biliary duct hamartomas, and many people have had surgery despite the clinically benign nature of these abnormalities. As per the findings of the study, individuals who exhibit signs of malignancy should be investigated further. Eyeballing for red flag symptoms, followed by a specialized imaging scan and invasive treatment, is the three-step approach to biliary duct hamartomas. Since our recommendations include a shift in strategy and do not contradict existing rules, there are likely to be few roadblocks to improvement; the key barriers being technological equipment and image quality. In this study, we intended to pave the way for future research in the field. In our opinion, the next decade will bring a better understanding of the characteristics of biliary hamartomas, disease symptoms, and better recognition of any suspicious features. These indications will aid in reducing the number of unneeded surgical or invasive operations. Finally, the findings of these future studies will allow the medical community to improve and provide the best care possible.

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“…Our analysis includes these 139 patients. Tables 3 , 4 , 5 [ 2 , 7 , 8 , 11 - 90 ] summarise the data from all of the cases studied.…”

Section: Reviewmentioning

confidence: 99%

Biliary Duct Hamartomas: A Systematic Review

Sheikh¹,

Nguyen²,

Leyba³

et al. 2022

Cureus

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“…Los estudios de inmunohistoquímica no son muy útiles, inclusive innecesarios para el diagnóstico y tienen el mismo fenotipo que los conductos biliares normales. El índice de proliferación celular determinado con el Ki67 es bajo o ausente, contrario a lo observado en las lesiones malignas (15).…”

Section: Quistes Simples: Biliares Mesoteliales Y De Intestino Anteriorunclassified

Neoplasias hepáticas benignas: variantes histológicas, problemas diagnósticos y diagnóstico diferencial

Panqueva

Pilar²

2015

Rev. Colomb. Gastroenterol.

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Un principio básico de la patología es que las neoplasias se diferencian según sus células de origen y en el hígado semejan sus constituyentes, sean las células hepáticas, del epitelio biliar, endoteliales, mesenquima- les o una combinación de estas. Es importante recordar aquí que son las metástasis el tumor maligno más frecuente del hígado, con una relación de 30:1 en pacientes sin enfermedad hepática crónica o cirrosis subyacente; es rara la presencia de las mismas en hígados cirróticos. Las neoplasias gastrointestinales del colon, páncreas, vía biliar extrahepática, estómago, tumores neuroendocrinos y GIST, o extraintestinales del pulmón, mama, melanoma o tumores de cabeza y cuello, son las más frecuentes (1). En este artículo solo revisaremos las más frecuentes. Iniciaremos con las neoplasias benignas y las lesiones pseudotumorales haciendo especial énfasis en aquellas con dificultades diagnósticas, en la utilidad de estudios especiales de inmunohistoquímica o moleculares para su adecuada clasificación y diagnóstico diferencial.

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