Multiple biomarkers based appraisal of deltamethrin induced toxicity in silver carp (Hypophthalmichthys molitrix)

Ullah, Sana; Li, Zhongqiu; Arifeen, Muhammad Zain Ul; Khan, Shahid Ullah; Fahad, Shah

doi:10.1016/j.chemosphere.2018.09.145

Cited by 82 publications

(27 citation statements)

References 66 publications

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“…In the current study, the exposure of V. verrucosa to λ-cyh increased the gill LOOH and MDA contents, a major product of LOP, suggesting that the λ-cyh treatment induces the formation of free radicals, which attack the PUFA of all membranes, causing instability, fluidity alteration, and degradation. Our findings were in agreement with the previous report by Ullah et al (2019), which indicated the damage of lipids through ROS overproduction after exposure to type II pyrethroids. The enhanced lipid oxidation following the bivalves’ exposure to λ-cyh might be attributed to the increase of H 2 O 2 levels in their gill tissues, as demonstrated by our experiment.…”

Section: Discussionsupporting

confidence: 94%

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Fatty acid profile and antioxidant status in Venus verrucosa gills as λ-cyhalothrin toxic effects

et al. 2020

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The aim of this study was to analyze the biochemical alterations in the gills of Venus verrucosa under exposure for 6 days to three doses of lambda-cyhalothrin (λ-cyh) (100, 250, and 500 µg L−1). Malondialdehyde, lipid hydroperoxide, and hydrogen peroxide levels in the gills of treated groups increased. λ-Cyh exposure significantly increased the protein carbonyl and reduced glutathione levels in the gills of all treated groups. Moreover, the activities of superoxide dismutase and glutathione peroxidase were increased. In our study, the polyunsaturated fatty acid (FA), omega-6, eicosapentaenoic acid (C20:5n-3), and docosahexaenoic acid (C22:6n-3) were increased in the treated groups. A significant decrease in the saturated FAs, omega-3, and arachidonic acid (C20:4n-6) levels was observed. The content of monounsaturated FA was changed in the groups treated with 100 and 250 µg L−1 of λ-cyh. As a corollary, desaturase and elongase activities were significantly increased. Our study provides evidence of the underlying toxic mechanism of λ-cyh and its capacity to create oxidative stress and revealed that FA profiling is a new approach for elucidating the λ-cyh toxicity.

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Section: Discussionsupporting

confidence: 94%

“…Moreover, this result was confirmed by the significant increase of the H 2 O 2 levels in the all treated bivalves. These results are in agreement with those of Ullah et al (2019), who demonstrated that the synthetic pyrethroids increased significantly the antioxidants activities in the silver carp ( Hypophthalmichthys molitrix ).…”

Section: Discussionsupporting

confidence: 93%

Fatty acid profile and antioxidant status in Venus verrucosa gills as λ-cyhalothrin toxic effects

et al. 2020

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“…Proteins not only play a significantly important role in almost all structures and functions of living organisms but are also used for energy generation and maintenance of homeostasis under normal and stressed conditions 37 . Decline in protein has also been related to weakening/ www.nature.com/scientificreports/ damage to the synthesizing machinery of fish under stress in previous studies [38][39][40] . The cells generally maintain essential functions by promoting or inhibiting synthesis or degradation of proteins 41 , however, under stress, protein degradation becomes a key process for production of ATP, liberation of amino acids and other substances for gluconeogenesis, synthesis of antioxidants and detoxification enzymes and to meet the energy demands [42][43][44] .…”

Section: Discussionmentioning

confidence: 98%

Biomarkers for the toxicity of sublethal concentrations of triclosan to the early life stages of carps

Dar

Sharma

Singh

et al. 2020

Sci Rep

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Accumulation, contents of protein, non-enzymatic antioxidant glutathione (GSH and GSSG), lipid peroxidation product (melondialdehyde-MDA) and organic acids (fumarate, succinate, malate and citrate), and activities of neurological (acetylcholinesterase-AChE), detoxification (glutathione S-transferase-GST) and metabolic (lactate dehydrogenase-LDH, aspartate transaminase-AST and alanine transaminase-ALT) enzymes were recorded in the hatchlings of Cyprinus carpio, Ctenopharyngodon idella, Labeo rohita and Cirrhinus mrigala after 7 and 14 days exposure and 10 days post exposure (recovery period) to sublethal concentrations (0.005, 0.01, 0.02 and 0.05 mg/L) of triclosan, a highly toxic and persistent biocide used in personal care products. Accumulation was maximum between 7–14 days at 0.01 mg/L for C. carpio and L. rohita but at 0.005 mg/L for C. idella and C. mrigala. No triclosan was observed at 0.005 mg/L in C. carpio and C. mrigala after recovery. Significant decline in protein, glutathione and acetylcholinesterase but increase in glutathione S-transferase, lactate dehydrogenase, aspartate transaminase, alanine transaminase, melondialdehyde and organic acids over control during exposure continued till the end of recovery period. Integrated biomarker response (IBR) analysis depicted higher star plot area for glutathione and glutathione S-transferase during initial 7 days of exposure, thereafter, during 7–14 days of exposure and the recovery period, higher star plot area was observed for acetylcholinesterase, aspartate transaminase, alanine transaminase and organic acids. Higher star plot area was observed for protein in all the species throughout the study. The study shows that L. rohita is most sensitive and glutathione, acetylcholinesterase, aspartate transaminase and alanine transaminase are the biomarkers for the toxicity of sublethal concentrations of TCS.

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“…Fish liver (or hepatopancreas) is a detoxification centre for almost all types of chemicals or toxicants (including pesticides) (Ullah et al., 2018), and fish gills are involved in a number of extremely important functions such as respiration, excretion, acid base balance and osmoregulation (Ullah et al., 2019). Fish gills are also the main organs in fish that come into contact with toxic substances in the environment (Mohamed et al., 1998).…”

Section: Discussionmentioning

confidence: 99%

Effects of calcein on the levels of antioxidant enzymes and lipid peroxidation in juvenile silver carp, Hypophthalmichthys molitrix

Lü

Chen

Xie

et al. 2020

Aquaculture Research

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Standard single‐exposure of calcein (CAL) was conducted on juvenile silver carp, Hypophthalmichthys molitrix, to examine its effects on antioxidant enzyme levels and lipid peroxidation. Juveniles were exposed to different concentrations of CAL solutions (0, 100, 300, 500 and 700 mg/L) for different immersion periods (12, 24, 48, 72 and 96 hr). Increased glutamate‐oxaloacetate transaminase, glutamate‐pyruvate transaminase and alkaline phosphatases activities were assumed to be due to CAL‐induced hepatic damage, probably because of the high potential of CAL to accumulate in fish hepatopancreas. Higher CAL concentrations (>300 mg/L) and prolonged immersion periods (>48 hr) could lead to greater toxicity in juvenile silver carp and, to a certain degree, damage the gills and hepatopancreas. The antioxidant responses in the gills and hepatopancreas result in successful elimination of the excess CAL‐induced reactive oxygen species for CAL exposure ≤24 hr. Our results confirmed that the toxic effects of CAL on antioxidant enzyme levels and lipid peroxidation in juvenile silver carp depended on both CAL concentrations and duration of exposure. Moreover, concentration of CAL solutions and the immersion period should be, respectively, restricted to ≤300 mg/L and ≤24 hr, when CAL is used for immersion marking juvenile silver carp.

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Multiple biomarkers based appraisal of deltamethrin induced toxicity in silver carp (Hypophthalmichthys molitrix)

Cited by 82 publications

References 66 publications

Fatty acid profile and antioxidant status in Venus verrucosa gills as λ-cyhalothrin toxic effects

Fatty acid profile and antioxidant status in Venus verrucosa gills as λ-cyhalothrin toxic effects

Biomarkers for the toxicity of sublethal concentrations of triclosan to the early life stages of carps

Effects of calcein on the levels of antioxidant enzymes and lipid peroxidation in juvenile silver carp, Hypophthalmichthys molitrix

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