Multiple Bonds to Germanium

Lee, Vladimir Ya.

doi:10.1002/9781119613466.ch10

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2023

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“…However, the field only began to intensively develop in the 1970s, when the first water-soluble organic germanium compounds were synthesized, gaining attention due to their wide range of biological activities. This topic has been addressed in several reviews [1,5,6,8,24,[36][37][38][39][40][41][42][43][44], as well as a monograph [7].…”

Section: Introductionmentioning

confidence: 99%

Physiological Activity of Trace Element Germanium Including Anticancer Properties

Менчиков

Popov

2023

Biomedicines

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Germanium is an essential microelement, and its deficiency can result in numerous diseases, particularly oncogenic conditions. Consequently, water-soluble germanium compounds, including inorganic and coordination compounds, have attracted significant attention due to their biological activity. The review analyzes the primary research from the last decade related to the anticancer activity of germanium compounds. Furthermore, the review clarifies their actual toxicity, identifies errors and misconceptions that have contributed to the discrediting of their biological activity, and briefly suggests a putative mechanism of germanium-mediated protection from oxidative stress. Finally, the review provides clarifications on the discovery history of water-soluble organic germanium compounds, which was distorted and suppressed for a long time.

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